PPT-Hemoglobin and anemia Hemoglobin

Hemoglobin is the protein molecule in red blood cells that carries oxygen from the lungs to the bodys tissues and returns carbon dioxide from the tissues back to the lungs Hemoglobin Hemoglobin . b. d. g. a. a. Chromosome 16. Chromosome 11. 25%. 25%. a. a. b. d. g. 25%. 25%. 48%. 48%. 1.5%. 0.5%. 1.5%. 0.5%. Hemoglobin synthesis. a. a. a. a. a. a. b. g. d. b. d. g. HbA. HbF. HbA. 2. 98%. ~1%. Hemoglobin. Hemoglobin is the protein molecule in red blood cells that carries oxygen from the lungs to the body's tissues and returns carbon dioxide from the tissues back to the lungs.. Hemoglobin. Hemoglobin (. Hemolysis. is defined as the premature destruction of red blood cells (RBCs).. Anemia results when the rate of destruction exceeds the capacity of the marrow to produce RBCs. Normal RBC survival time is 110. Adult male: 4.6 – 6 million. Adult female: 4.2 – 5 million. Red blood cells are: . Tiny, flexible biconcave discs. Lacks a nucleus. Can bend when going through tiny capillaries. RBC’s are constantly manufactured. Definition of Anemia. Who here is anemic?. Newborn baby boy with hemoglobin 12.8 g/. dL. 2 month-old baby girl with . hgb. 9.5 g/. dL. 4 year-old girl with . hgb. 10.6 g/. dL. 16 . y.o. . boy with . April 12, 2014. Virginia Harrod, MD, PhD. Pediatric Hematology Oncology. Overview . Definition of anemia. Review of CBC values. Review of Hemoglobin. Types of Anemia. Microcytic, macrocytic, normocytic. OBJECTIVES. Describe the . structure . of hemoglobin molecule. Describe . synthesis . of hemoglobin in brief.. List the . functions. of hemoglobin.. Enlist . various types. of normal and abnormal hemoglobin’s.. globin. chains. Abnormalities in these proteins are referred to as . hemoglobinopathies. Two hemoglobin gene clusters are involved in the production of hemoglobin and are located at the end of the short arm of chromosomes 16 and 11, respectively. . is defined as the premature destruction of red blood cells (RBCs).. Anemia results when the rate of destruction exceeds the capacity of the marrow to produce RBCs. Normal RBC survival time is 110. –. ESSAM . AHMED. M.B.Ch.B. , F.I.B.M.S. Peadiatric. . Hemato. -Oncologist. Objectives. 1- to understand the definition of anemia and recognize its different types according to . their etiology. 2- to be able to approaches to patient with anemia (investigations and treatment. Hemoglobin. . Found in the RBC.. Responsible for carrying oxygen to all cells in the body.. Also binds to carbon dioxide and carries it to the lungs from the cells to be released.. Buffer against change in [H. Department of internal medicine 1. with course of cardio-vascular pathology. Complete blood count (CBC). RED BLOOD CELL COUNT. M – 4,5-5,5 *10. 12. ; F – 3,5-4,5 *10. 12. . HEMOGLOBIN. M – 130-160 g/l (13-16 mg/dl); . 471. Objectives. Quantitative determination of hemoglobin in a blood sample.. . Hemoglobin structure. Hemoglobin (. Hb. ) is a . porphyrin. –iron (II) . protien. in RBCs that transport oxygen from the lungs to the rest of the body and carbon dioxide back to the lungs.. Anemia is a general term for most common blood disorder in the world.. Anemia is a symptoms of a wide variety of mild to serious diseases, disorder and conditions.. Anemia is defined as:-. - A reduction below normal in the volume of .