PPT-BONE MARROW TARGETING AND TARGETING TO LYSOSOMAL DISEASES

By SOMESHWARK MPHARM II SEMESTER Department of Pharmaceutics University College of Pharmaceutical Sciences KAKATIYA UNIVERSITY. Normal adult Bone marrow in old age Neonatal bone marrow Bone Marrow Cellularity Cellularity Age Site hemopoietic cellsfat Neonate All bones liver spleen 1000 Child Most bones 7030 Adult Axial skeleton 5050 Old age Axial skeleton 3070 brPage 2br Cel Undernutrition. 61/2 m/o ex 34 WGA twins with:. FTT. Severe Global Developmental Delay. Hypertonia. Oculomotor. findings. Reflux. Intermittent Diarrhea. HSM. h/o . neutropenia. and thrombocytopenia. Digital Laboratory. It’s best to view this in . Slide Show . mode, especially for the quizzes.. This module will take approximately . 20 . minutes to complete.. After completing this exercise, you should be able to:. and more. skeleton. made up of. bones – cartilage – ligaments – tendons. bones . are a major part of the skeleton and . provide. support. – organs, teeth, viscera. protection. – brain, CNS, marrow, viscera. Blood Neoplasms, and Bone Marrow Transplantation. Chronic Myeloproliferative Neoplasms (MPN) . Ph-negative. Marta Sobas. MPN. Ph. CML. Ph (-). Ph (+). PV. ET. MF. AML. Myeloid disorders. MDS. Increased. Classification of bone diseases. . It is not easy to classify bone diseases, since many of them are of unknown etiology or . their nature . is poorly understood. .. . Hereditary. 1. . Cheurbism. (fibro-osseous lesion).. Lauren . Cosolo. , RN, BScN, MN. Outline. Review bone marrow failure and disease. Discuss . Myelodysplastic. syndrome, pathophysiology, clinical presentation, diagnosis, treatment. Discuss Aplastic Anemia, . Pancytopenia. Pancytopenia. . is a reduction in the blood count of all the major. cell lines – red cells, white cells and platelets. It has several causes. which . can be broadly divided into . decreased bone marrow . 59 Procedure Name of the Fellow: Successfully completed a bone marrow biopsy simulation course ? YES NO N/A I. Procedure Preparation: □ List indications . □ Check labs, medication Dr. Ali Khazaal Jumaa. F.I.B.M.S (Internal Medicine). F.I.B.M.S (Clinical Hematology). Gross anatomy and histology. Bone marrow is a jelly-like substance that fills the cavity left by the trabecular network of bone. It accounts for about 4 – 5% of the total body weight of an individual. It is responsible for producing platelets, lymphocytes, erythrocytes, granulocytes and monocytes.. Part 2. Wendy Blount, DVM. Slide Preparation. Pipette flecks out of the petri dish and put on glass slides immediately. Elevate one end of the slide to let extra blood run . off. Slide Preparation. Pipette flecks out of the petri dish and put on glass slides immediately. Osteitis. . is . a . localized inflammation of bone with no progression through the marrow spaces. particularly that associated with infected . sockets.. . Osteomyelitis. is a more extensive inflammation of the interior of the bone involving and typically spreading through the marrow spaces. . Konstantin Alexeev; . Haodong. Zhou, BSc; Guy . Trudel. , MD; Odette . Laneuville. , . Ph.D. ;. Department of Biology (Faculty of Science) and Bone and Joint Research Laboratory (Faculty of Medicine) . ®. Hematopoietic Stem Cells (HSCs) are capable of developing into any blood cell lineage. They develop in the bone marrow.. A small percentage of HSCs interacted with the . endosteal. niche, SNO cells, and osteoblasts..