PPT-Bone Marrow Failure Diseases: Including MDS, AA, PNH

Lauren Cosolo RN BScN MN Outline Review bone marrow failure and disease Discuss Myelodysplastic syndrome pathophysiology clinical presentation diagnosis treatment Discuss Aplastic Anemia . Normal adult Bone marrow in old age Neonatal bone marrow Bone Marrow Cellularity Cellularity Age Site hemopoietic cellsfat Neonate All bones liver spleen 1000 Child Most bones 7030 Adult Axial skeleton 5050 Old age Axial skeleton 3070 brPage 2br Cel By. . SOMESHWAR.K. M.PHARM.. II - SEMESTER . . . Department of Pharmaceutics. University College of Pharmaceutical Sciences,. KAKATIYA UNIVERSITY. and more. skeleton. made up of. bones – cartilage – ligaments – tendons. bones . are a major part of the skeleton and . provide. support. – organs, teeth, viscera. protection. – brain, CNS, marrow, viscera. Brian Boulmay. , . MD. Bone Marrow Failure . Ineffective marrow-poeisis is the final endpoint of many diseases. . Congenital. Acquired . Genetic. Environmental or iatrogenic causes. Congenital marrow failure can present at any age.. Josu. de la . Fuente. Departments of Paediatrics and Haematology. Imperial College London. 25% of paediatric and 10% of young adult patient presenting with aplastic anaemia. Fanconi Anaemia. Median age of presentation 7 years of age. Pancytopenia. Pancytopenia. . is a reduction in the blood count of all the major. cell lines – red cells, white cells and platelets. It has several causes. which . can be broadly divided into . decreased bone marrow . Radhi. Types of Bone. Intramembranous. Endochondral. (epiphyseal . bone). Intramembranous. Small bones. Immediately from . Mesynchymal. cells. (. Mesynchymal. cells change into bone immediately (. na. ji. Leukopenia. . Leukopenia. refers to the decrease in the number of white blood cells (WBC) in blood. . Causes of . Leukopenia. Leukopenia. may be caused by various diseases and drugs. Some of these are outlined here:-. 59 Procedure Name of the Fellow: Successfully completed a bone marrow biopsy simulation course ? YES NO N/A I. Procedure Preparation: □ List indications . □ Check labs, medication Fibrosis Figure Legend: Figure 1 Dense fibrous tissue surrounded by areas of angiectasis is present in bone marrow in a male F344/N male rat from a chronic study. Figure 2 Higher magnification of Fig - tion (Figure 1). Skeletal aging is characterized as a gradual loss of bone mass due to an excess of bone resorption that is not matched by new bone formation. There are two major types of bone Part 2. Wendy Blount, DVM. Slide Preparation. Pipette flecks out of the petri dish and put on glass slides immediately. Elevate one end of the slide to let extra blood run . off. Slide Preparation. Pipette flecks out of the petri dish and put on glass slides immediately. Osteitis. . is . a . localized inflammation of bone with no progression through the marrow spaces. particularly that associated with infected . sockets.. . Osteomyelitis. is a more extensive inflammation of the interior of the bone involving and typically spreading through the marrow spaces. . Celalettin Ustun, MD. Rush University. Division of Hematology-Oncology-Cell Therapy. Director, Section of Cell Therapy. The Aplastic Anemia and MDS International Foundation. A virtual patient and family conference .