PPT-Bone Marrow Failure Diseases: Including MDS, AA, PNH

Lauren Cosolo RN BScN MN Outline Review bone marrow failure and disease Discuss Myelodysplastic syndrome pathophysiology clinical presentation diagnosis treatment Discuss Aplastic Anemia . Normal adult Bone marrow in old age Neonatal bone marrow Bone Marrow Cellularity Cellularity Age Site hemopoietic cellsfat Neonate All bones liver spleen 1000 Child Most bones 7030 Adult Axial skeleton 5050 Old age Axial skeleton 3070 brPage 2br Cel By. . SOMESHWAR.K. M.PHARM.. II - SEMESTER . . . Department of Pharmaceutics. University College of Pharmaceutical Sciences,. KAKATIYA UNIVERSITY. J. Christian Barrett, MD. Pathophysiology of PNH. Paroxysmal Nocturnal . Hemoglobinura. A disease of the hematopoietic stem cell. Non-malignant . clonal. disease. Defective post-translational processing of . Richard Hostin, M.D.; . Eric. . Klineberg, M.D.; Shay Bess, M.D.; Munish Gupta, M.D.; International Spine Study Group. Presenter: . Richard . Hostin. (. a,d. ) . DePuy. Spine; (e) Axial Biotech. Co-Authors: Eric . MBChB. , PhD1*, Britta . Höchsmann. , MD2*, Austin Kulasekararaj3*, Sophie de . Guibert. , MD4*, Alexander . Röth. , MD5*, Ilene C . Weitz. , MD6, . Elina. Armstrong, MD, PhD7*, Anita Hill, . MBChB. C. linical Perspective. Mary Ward, RN, BS, CTR. Objectives. To increase the Cancer Registrar’s knowledge of the disease process of select cancers of the bone marrow from a clinical perspective. Discuss the pathogenesis, clinical evaluation and treatment options of AML, APL, MDS and Multiple Myeloma . Professor of Pediatrics, Harvard Medical School. Director, Bone Marrow Failure and Myelodysplastic Syndrome Programs. Jim Connelly, MD. Assistant Professor of Pediatrics, Vanderbilt University Medical Center. Pancytopenia. Pancytopenia. . is a reduction in the blood count of all the major. cell lines – red cells, white cells and platelets. It has several causes. which . can be broadly divided into . decreased bone marrow . Dr. M. Sabloff. Director of the Leukemia Program at the Ottawa Hospital. October 13. th. 2018. Disclosures . Objectives. Aplastic anemia. Epidemiology. Treatment options. P. NH. Epidemiology. Treatment. The Focus section seeks to publish relevant and timely continuingeducation for clinical laboratory practitioners. Section editors, topics,and authors are selected in advance to cover current areas of Fibrosis Figure Legend: Figure 1 Dense fibrous tissue surrounded by areas of angiectasis is present in bone marrow in a male F344/N male rat from a chronic study. Figure 2 Higher magnification of Fig Celalettin Ustun, MD. Rush University. Division of Hematology-Oncology-Cell Therapy. Director, Section of Cell Therapy. The Aplastic Anemia and MDS International Foundation. A virtual patient and family conference . JR2, GENERAL MEDICINE. TDMCH. BONE MARROW FAILURE SYNDROMES . HYPOPROLIFERATIVE ANEMIA . APLASTIC ANEMIA. MYELODYSPLASTIC SYNDROME. PURE RED CELL APLASIA. MYELOPHTHISIS. APLASTIC ANEMIA: DEFINITION. PANCYTOPENIA + BM HYPOCELLULARITY. 3 YEARS. Demographics of Germany. . [1910 – 2050] and Europe. Statistisches Bundesamt, 2002. Eurostat. 2004-Percentage of people over age of 60 years in 2031. The Bone Marrow Failure Syndromes. AA.