PPT-VASCULITIS ( Part 2) Mustafa E. Al-Badran

CABM FIBMS Internist amp Rheumatologist Large Vessel Vasculitis Takayasu arteritis Mikito Takayasu  1860    1938  Japanese ophthalmologist CLINICAL FEATURES Diagnosis By angiography which reveals Coarctation occlusion ampaneurysmal dilatation. Mustafa Ali Page 2 06/08/2005 (1067) O Eve, in evil hour thou didst give ear (1068) To that false worm, of whomsoever taught (1069) To counterfeit man By: Dr. Donna Braham. Objectives. Classify Vasculitis. Know when to consider Vasculitis. Rule out mimickers of Vasculitis. Diagnose cutaneous small vessel vasculitis – In . particular Henoch–. Schönlein. Takayasu’s arteritis, giant cell arteritis and primary CNS angiitis all have granulomatous angiitis. Takayasu’s arteritis:. This affects the aortic arch, main arterial trunks and descending aorta including the carotid and subclavian arteries. The clinical features of the various . vasculitides. are protean and largely depend on the vascular bed affected (e.g., CNS vs. heart vs. small bowel). . Besides the findings referable to the specific tissues involved, the clinical manifestations typically include constitutional signs and symptoms such as fever, . aortitis. ?. Emily Grodinsky. 11.5.2020. Categorizing vessels by size. More on primary vasculitidities. Even diseases like GCA/. Takayasu. arteritis have significant effects from the smaller vessels (e.g., ophthalmic or retinal arteries in GCA leading to significant morbidity, despite not being “large vessels”). Signs and symptoms:. 1- . local. :. according. to the involved tissue. 2- . systemic. :(fever, . myalgia. , . arthralgias. , and malaise). Pathogenesis . 1- immune-mediated inflammation. . 2- . infectious pathogens. CABM FIBMS. The most rapid and destructive joint disease. The incidence . 2–10 per 100 000 in the general population . 30–70 per 100 000 in population with pre-existing joint disease or joint replacement. CABM FIBMS. OSTEOPOROSIS. Reduced bone density, which causes micro-architectural deterioration of bone tissue and leads to an increased risk of fracture (fragility fractures). Fragility Fractures. Defined as fractures result from falling from a standing height or less (occur spontaneously or following minimal trauma) . . Vasculopathy. Fibrinoid deposition, thrombosis with limited to no inflammation.. Infiltration of vessel wall by inflammatory cells with otherwise minimal alteration.. Leukocytoclasis. of tissue infiltrate with minimal alteration of vessel, that is, swelling only, absence of fibrinoid. PRESENTER- Dr. B. PRADEEP.. CHAIR PERSON- Dr. T. SMRUTHI.. Vasculitis are group of disorders characterized by . immunoinflammatory. injury to vessel wall . leading to aneurysm, bleeding, stenosis, occlusion, thrombosis, embolism and ischemia. . 1. GHADA BADRAN. MRCOG . tutor . MRCOG Part 2 course. july. . 2021 exam . 2. \. 07 . \. 2021. https. ://. www.drghadabadran.com. . MRCOG PART 2 . ghada. . badran. group . . CABM FIBMS. Internist and Rheumatologist . Epidemiology. . Ethnic differences . Knee OA higher in Africa, China, Japan and the Indian subcontinent . Hip O.A higher in European countries. Pathophysiology. CABM FIBMS. College . of Medicine\ University of Basrah. Objectives. What is cerebellum. The Functions of  cerebellum. Anatomical areas of cerebellum. Input (afferent) Pathways to the Cerebellum. Output (Efferent) Signals from the Cerebellum. aortitis. ?. Emily Grodinsky. 11.5.2020. Categorizing vessels by size. More on primary vasculitidities. Even diseases like GCA/. Takayasu. arteritis have significant effects from the smaller vessels (e.g., ophthalmic or retinal arteries in GCA...