PPT-Gene Finding BCH364C/394P Systems

Biology Bioinformatics Edward Marcotte Univ of Texas at Austin Lots of genes in every genome Nature Reviews Genetics 13329342 2012 Do humans really have the biggest genomes. biomolecular. networks in physiology and disease. Kakajan Komurov, . Ph.D. Department of Systems Biology. University of Texas MD Anderson Cancer Center. Classical to Systems Biology. Gene 1. Function 1. ORFans. to . “GO”. Genomic sequence of model eukaryote . Saccharomyces cerevisiae . completed in 1996. (12.1 Mb). Despite 16 years of intense research, function of nearly 30% of putative open reading frames (ORFs) remain unknown.. Patricia . Cadden. , Senior Commissioner . And. . Chris . Hart, Independent Nurse Consultant. Been here before?. What we’ll be talking about. Introduction. Reasons for commissioning the RDIC Custody. Patricia . Cadden. , Senior Commissioner . And. Chris Hart, Independent Nurse Consultant. What we’ll be talking about. Introduction. Reasons for commissioning the RDIC Custody. Taking a moment. The work to date. BMI/CS 776 . www.biostat.wisc.edu/bmi776/. Spring . 2018. Anthony Gitter. gitter@biostat.wisc.edu. These slides, excluding third-party material, are licensed under . CC BY-NC 4.0. by Mark Craven, Colin Dewey, and Anthony Gitter. BMI/CS 776 . www.biostat.wisc.edu/bmi776/. Spring . 2018. Anthony Gitter. gitter@biostat.wisc.edu. These slides, excluding third-party material, are licensed . under . CC BY-NC 4.0. by Mark . Craven, Colin Dewey, and Anthony Gitter. Lecture 3. Gene Finding and Sequence Annotation. Objectives of this lecture. Introduce you to basic concepts and approaches of gene finding. Show you differences between gene prediction for prokaryotic and eukaryotic genomes. BMI/CS 776 . www.biostat.wisc.edu/bmi776/. Spring 2020. Daifeng. Wang. daifeng.wang@wisc.edu. These slides, excluding third-party material, are licensed . under . CC BY-NC 4.0. by Mark . Craven, Colin Dewey, Anthony . Edward . Marcotte. , . Univ. of Texas at Austin. Lots of genes in every genome. Nature Reviews Genetics . 13:329-342 (2012). Do humans really have the biggest genomes?. Genome . size . ranges vary widely across organisms. What’s the problem?. How did I solve it?. What did I find?. Would you like to know more?. Pre mRNA needs to get cut in an ordered fashion. So splicing elements cue splicing factors to splice. . This can be regulatory . 6-. 2. Objectives. Define system requirements and differentiate between functional and nonfunctional requirements. . Understand the activity of problem analysis and be able to create an Ishikawa (fishbone) diagram. . genomic . medicine . Olivier Bodenreider and David Herion. National Institutes of Health, Bethesda, Maryland, USA. London, UK. April 11, 2010. SNOMED CT. Genomics Session. Motivation. What concepts should be available on a problem list in the era of genomic medicine?. HMM ‘fair-coin’ example. October 09. E. F. (H)=0.5. E. L. (H)=0.1. 0.6. 0.6. 0.4. 0.4. 1. H H T T T is the observed sequence. October 09. E. F. (H)=0.5. E. L. (H)=0.1. 0.6. 0.6. 0.4. 0.4. 0. 1. 0.6. (course # 53545/53436). Spring 2020 Tues/Thurs 11 – 12:30 PM JGB 2.202. Instructor: Prof. Edward Marcotte marcotte@icmb.utexas.edu . Office hours: Wed 11 – 12 MBB 3. 148BA.