PPT-DNA Replication and Repair

Semiconservative vs Conservative DNA Polymerase RNA Primase Okazaki Fragments Replication Errors TeachWithFergy Preview File Please enjoy this preview of your Power Point Some slides appear blank because they have been removed. MUTAGENESIS. DNA DAMAGE. DNA REPAIR. RECOMBINATION. MUTAGENESIS. Mutations. Mutations are heritable permanent changes in the base sequence of DNA.. Point mutations may be . transitions. (e.g. GC→AT) or . GO TO . BIOINTERACTIVE WEBSITE. DNA replication questions. Why is DNA replication so important?. In what part of the cell cycle does DNA replication occur?. What enzyme brings in the new DNA nucleotides that form complimentary pairs with the old DNA strand?. SC.L.16.3 . Describe . the basic process. of . DNA replication . and how it relates . to the . transmission . and . conservation. of . the genetic information. DNA and Its structure. DNA (deoxyribonucleic acid) is a large organic. WHAT YOU WILL LEARN. -process of DNA making copies . -role of enzymes in copying DNA. -leading and lagging strands in DNA replication. READING Q. ’. s . 1-LIST:. -the 3 phases of semi-conservative replication. Objectives:. 1. Summarize the roles of the different enzymes involved in replication of DNA.. 2. Explain how the leading and lagging strands are replicated differently . Semiconservative. Replication. . §. 4.3a DNA Replisome. . §. 4.3b DNA Damage. §. 4.3c DNA . Repair. IV. NUCLEAR BIOCHEMISTRY. §. 4.3a . DNA Replisome. Synopsis . 4.3a. DNA replication involves making . copies or “. replicas” of DNA. BIO…. LIFE….. THINK ABOUT THIS: . What do we do in our lifetime?. What are the major stages of our life?. What are the Major stages of physical development in our lives?. What would it look like.  . Author: Michael Fenech. Affiliation: Genome Health Foundation, North Brighton, SA, 5048, Australia. Email: . mf.ghf@outlook.com. . Introduction. Life as we know it depends entirely on the capacity of cells to utilize energy and molecules in the environment for cellular function and reproduction. . . Understanding DNA structure and replication is a prerequisite for understanding/using the principal tools of molecular biology . R. R. 0. R0. R0. 0. R0. R0. R. 0. R. RR. R0. 0. R0. 00. DNA: Structure & Replication. If we have an error one in a million this mean we will have 3000 errors during each replication cycle of the genome.. The genome of a typical mammalian cell . accumulates many . thousands of lesions during a 24-hour period.. of intense freckling and high melanoma incidence, related to UV sensitivity. The syndrome actually results from defects in any of nine genes involved in repair of UV damage. C. EPAIRING DAMAGED OR ABSTRACT Chemotherapy often targets dividing cells by causing DNA damage that leads to replication-dependent toxic lesions. Cells possess several overlapping DNA damage repair pathways that allow them REPLICATION ERRRORS AND THEIR REPAIR. The nature of mutations. Transitions. Transversions. Some replication errors escape proofreading. Mismatch repair removes errors that escape proofreading. Structure of . Mitosis, Protein . Synthesis. Week 8. 9/29 . DNA Replication . 11.1. Obj. TSW demonstrate base pairing rules of DNA Replication by constructing a 2-D model of DNA with paper. . P. 68 NB. Replication Video.