PPT-A Comprehensive Review of p53 Mutations and Cancer Incidence in Companion Animals

Presented by Amit Levi Class of 2022 Mentor Dr Xinbin Chen Department of Surgical amp Radiological Sciences P53 is a major tumor suppressor known as the guardian of the genome. This means that 1 in every 733 babies is born with this condition Although parents of any age may have a child with Down syndrome 80 are born to women under the age of 35 NICHCY Disability Fact Sheet 4 June 2010 Definition Definition Definition Defi C. ancer. Outline. Disease related to p53 . Role. . and regulation pathway. Structure of p53 . Missense mutation and consequences. E. xperiment’s proposal of p53 missense mutant cancer. I. Diseases cause by mutated p53. Novel biomarkers for AKI early diagnosis. Sepsis associated Acute Kidney Injury is a serious complication with high mortality . Identifying . early markers of kidney damage has been . difficult. Two novel . P53 Tumor . Supressor. Protein. TP53. Tumor Suppressor Gene. While commonly known as p53, the official name of this gene is Tumor Protein p53 and its official symbol is TP53. . The TP53. gene codes . Cancer can be caused by mutations to genes that regulate cell growth and division. Tumor viruses can cause cancer in animals including humans. Oncogenes and Proto-Oncogenes. Oncogenes . are cancer-causing genes. (© Garland Science 2007). Cell Cycle Checkpoints. The Guardian Mechanisms of . the Genome. THEY ARE DISRUPTED. IN CANCER!. Entering Mitosis Before the Completion of S phase is. Bad for Chromosomes and Therefore Bad for Cells . Protein Cell Indian God of Destruction Mian WuProtein Cell Yide Mei and Mian Wu 118 Higher Education Press and Springer-Verlag Berlin Heidelberg 2012 Figure 1 The schematic representation of Siv The sequence of bases in DNA are like the letters of a coded message or even the letters of a simple alphabet. . If we change the sequence of the letters do we change the nature of the message?. That . Understand how they occur. Analyze the different types of mutations. Understand how mutations affect amino acid sequences and proteins. Objective. Central Dogma. DNA is transcribed into RNA, RNA is translated into proteins. permanent change . in the DNA sequence of a gene. .. . Mutations . in a . gene's DNA sequence. can alter . the amino acid sequence . of the . protein. encoded by the gene.. GOOD BAD NEUTRAL. Donna L. White, . Abiodun. . Oluyomi. , . Yongquin. Dong, Peter Richardson, Harrison Nguyen, Aaron Thrift, Kathryn Royse, Elaine Chang, Li Jiao, Jose M. Garcia, Jennifer R. Kramer, Sarah Ahmed, Elizabeth Chiao. Valentina Barcherini . 1,. *, Margarida Espadinha . 1. , Joana Soares . 2. , Sara Gomes . 2. , Alexandra Antunes . 3. , . Lucília Saraiva . 2. , Maria M. M. Santos . 1. 1. Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Av. . Larry F Ellison (presenter. ), Centre for Population Health Data . and . Tracey . Bushnik, Health Analysis Division. 1. Background. Up to 2012, rapid increases in TC incidence have occurred…. In Canada, thyroid cancer (TC) was the fifth most diagnosed cancer among females in 2016…. Subramanian M. 1. , . Francis P. 1. , . Bilke. S. 1. , . Li XL. 1. , . Hara T. 1. , . Lu X. 2. , . Jones MF. 1. , . Walker RL. 1. ,. Zhu Y. 1. , . Pineda M. 1. , . Lee C. 3. , . Varanasi L.