Britton Chance Life Times amp Legacy Symposium and Workshop Translational Research in Near Infrared Based Functional Brain Imaging Banu Onaral PhD HH Sun Professor and Director School of Biomedical Engineering ID: 796985
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Slide1
June 3 & 4, 2011Philadelphia PA, USA
Britton Chance:
Life, Times, & Legacy
Symposium and Workshop
Translational Research inNear Infrared Based Functional Brain Imaging
Banu
Onaral, PhD
H.H. Sun Professor and Director
School of Biomedical Engineering,
Science &
Health Systems
Drexel University, Philadelphia, PA
banu.onaral@drexel.edu
Slide2Realizing BC’s dream…
…Move discoveries to practice
>> Portable Near-Infrared Technology for
Detection
of Hematoma
>> Portable Near-Infrared Technology for
Brain Activity Monitor
Slide3BC’s Dream Team
Adrian Curtin
Shoko Nioka
Slide4Outline
Optical Brain Imaging (fNIR) Physiological and Physical Principles Chance-Drexel fNIR
Technology EvolutionApplicationsRegional and Global Collaborations
Human Performance, Brain Integrated Simulation… Translational Research
Clinical SolutionsConclusion
Slide5Functional Near-Infrared Monitor [fNIR]
>> Cortical activation-related to hemodynamic changes in natural environments and diverse field conditions
Optical Brain Imaging
Near Infrared Based Platform
Slide6Physiological Principles of
fNIR Neural Activity & Hemodynamic Response
Neurons consume energy (glucose) when activated
Oxygen is required to metabolize the glucoseAs clusters of neurons are activated, there is an increased need for oxygen
in that areaOxygen is transported to neural tissue via oxy-hemoglobin in the bloodOxy-Hb and deoxy-Hb are correlates of brain activity through oxygen consumption by neurons
The oxygen exchange occurs in the capillary beds
As
oxy-hemoglobin
gives up oxygen to the neural tissue, it is transformed into
deoxygenated hemoglobin
David J.
Heeger
& David
Ress
. (2002)What does fMRI tell us about neuronal activity? Nature Reviews Neuroscience 3, 142-151
Slide7Source
Detector
Physical Principles of
fNIR
I
Photon Migration in Tissue
H Obrig , R Wenzel, M Kohl, S Horst, P Wobst, J Steinbrink, F Thomas, A Villringer.
Near-infrared spectroscopy: does it function in functional activation studies of the adult brain? International Journal of Psychophysiology 35(2-3):125-142, 2000
Photons that enter the tissue
undergo
two types of interaction:
Scattering
(cell membranes)
Absorption
(
Hb
, HbO
2
, water
)
Slide8Physical Principles of
fNIR II
Near IR
Optical Window in Tissue
.G
Stimuli
Presentation
Initial Dip
Peak
Oxygenation
Post stimulus
undershoot
Modified
Beer-Lambert
Law
.G
I
o
I
Slide9Early versions of
continuous wave (CW) system
Current version of CW system
Chance-Drexel
fNIR Technology Evolution
fNIR
System 100
fNIR
Devices, LLC
RunMan
,
Cogniscope
NIM, Inc
Slide10Early versions of
wireless system (PDA based)
Wireless pediatric system (ZigBee
)
Adhesive stick-on wireless systemChance-Drexel fNIR Wireless Technology Evolution
Sensors
Programmable/
Transmitter IC
Embedded in a head band
with batteries
Wireless Link
data
Slide11CONQUER
CollabOrative
Cognitive Neuroengineering & Quantitative Experimental Research Collaborative
A
unique brain function research facility that houses human experiment rooms equipped with
brain
activity monitoring modalities, such as
near-infrared
based
functional optical brain imaging [
fNIR
]
electroencephalogram [EEG]
experimental
protocol design tools and simulation
technologies
sensor
and device test &
technology development labs
Slide12Brain Computer Interface (BCI)
Neurorehabilitation in Traumatic Brain injury
Pediatric monitoring, etc…CONQUER
CollabOrative (Cont’d)
Cognitive Neuroengineering & Quantitative Experimental Research Collaborative
Human Performance and Training
Cognitive workload assessment…
Brain integrated Learning (
Neuro
-Learning)
Math, Reading
,
Problem solving
Motor Learning
Learning Disabilities
Strong emphasis on collaborative research in the field of
Slide13University of Maryland (Dr. José L. Contreras-Vidal)
University of Pittsburgh (Dr. Joseph Ricker)
Albert Einstein College of Medicine (Dr. Roee Holtzer)
Italy – Polytechnic University of Milan (Dr. Sergio
Cerutti) Spain – University
of
Seville
(
Dr. Jose Leon-Carrion)
–
Hospital
Nacional
de
Paraplejicos
Toledo (Dr.
Guglielmo Foffani)
Israel –
Haifa University (Dr. Zvia Breznitz) Hebrew
University (Dr. Esther Shohami)
Turkey
– Middle East
Technical
University
(Dr. Veysi Isler)
–
Dokuz
Eylul
University
(Dr. Murat
Ozgeren
)
China
–
Wuhan National Laboratory for Optoelectronics
(Dr
.
Shoko
Nioka
)
Med-X, Shanghai
Jiao
Tong
University
Shanghai Mental Health Center
United
Kingdom
–
The
Defence
Science and Technology Laboratory (DSTL)
Japan
–
Bukkyo
University
(Dr.
Yasufumi
Kuroda)
Global Collaborations
in Functional Optical Brain Imaging
Slide14Human Performance Assessment…
Optical Brain Imaging
Slide15Human Performance Assessment
Defense
Advanced Research Projects Agency (DARPA
)
Augmented Cognition Program
©
Slide16Brain integrated
Simulation…“Brain in the Loop”Optical Brain
Imaging
Slide17Problem Solving & Math Learning
Tangram
Arithmetic
Slide18Language Learning & Learning Disability
Brain
activity of regular and dyslexic readers Learning enhancement…identifying
processing similarities and differences between special populations and control groups
Director: Prof. Zvia Breznitz
…Lexical Decision Task
Brain activity during language learning (Hebrew,…)
Slide19Simulation & Multimedia Application
Brain Activity Monitoring in VR Environment
Slide20Clinical Solutions…
Optical Brain Imaging
Slide21…Solutions
Traumatic Brain Injury
>> Portable Near-Infrared Technology for
Detection of Hematoma
Near Infrared Based Platform
Hasan
Ayaz
,
PhD
BIOMED
Banu
Onaral, PhD
BIOMED
Baruch
Ben Dor, PhD
BIOMED
Optical Brain Imaging…
Meltem
Izzetoglu
, PhD
BIOMED
Kambiz
Pourrezaei, PhD
BIOMED
Infrascanner
TM
Slide22Life Saving…
…Solutions
Pediatric Monitoring
>> Functional Optical Brain Imaging Sensor
Near Infrared Based Platform
Meltem
Izzetoglu, PhD
BIOMED
Banu
Onaral, PhD
BIOMED
Harel
Rosen, MD
Neonatology, CHOP
Arye
Rosen, PhD
BIOMED
Kambiz
Pourrezaei, PhD
BIOMED
fNIR Sensor
for Neonates
Slide23>> Assessment of Cognitive Impairment and Recovery
Following Traumatic Brain injury (TBI)
Life Saving…
…Solutions
Neurorehabilitation
Near Infrared Based Platform
Healthy
Subject
Banu
Onaral, PhD
BIOMED
TBI
Patient
Maria
Schultheis, PhD
Psychology, CoAS
Anna C.
Merzagora
,
PhD
BIOMED
Slide24Life Saving…
…Solutions
Near Infrared Based Platform
fNIR
Awareness Monitor
Banu
Onaral, PhD
BIOMED
George
Mychaskiw, MD
Anesthesiology, COM
Patient wearing fNIR Sensor
James
Reynolds, MD,
COM
Kurtulus
Izzetoglu, Ph.D
BIOMED
>> Portable fNIR system
for monitoring
depth of anesthesia
to prevent
awareness during surgery
Depth of Anesthesia
Kambiz
Pourrezaei, PhD
BIOMED
Meltem
İ
zzeto
ğ
lu
,
Ph.D
BIOMED
Slide25Optical Brain Imaging…
…Solutions
Cognitive Aging
Near Infrared Based Platform
Banu
Onaral, PhD
BIOMED
Kurtulus
Izzetoglu
BIOMED
Roee Holtzer
Albert Einstein
CoM
Meltem
Izzetoglu, PhD
BIOMED
Joe Verghese, MBBS, MS
Albert Einstein, CoM
fNIR
Subject wearing
fNIR
during attention task
Brain activity monitor while walking
>>
Assessment of cognitive functions in natural settings
Slide26Optical Brain Imaging…
…Solutions
Autism,
Schizophrenia…
Near Infrared Based Platform
Drexel Optical Brain Imaging Team
Scott Bunce, PhD
Psychiatry, Penn State University COM
Personality and psychiatric disorders...
Functional Optical Brain Imaging Sensor
Banu
Onaral, PhD
BIOMED
Kambiz
Pourrezaei, PhD
BIOMED
Slide27Optical Brain Imaging…
…Solutions
ALS, Spinal Cord Injury, Paralysis
Near Infrared Based Platform
Terry Heiman-
Patterson, MD
Neurology, COM
Banu
Onaral
, PhD
BIOMED
Target Patient Population:
Amyotrophic Lateral Sclerosis (ALS)
Spinal Cord Injuries/Paralysis
Cerebral Palsy, Muscular Dystrophy
Brainstem Stroke, and others…
Hasan
Ayaz
, PhD
BIOMED
Patricia Shewokis, PhD
Nursing, CoNHP
>> Brain
Computer Interface
(
BCI
)
Slide28Life Saving…
…Solutions
Depression, Chronic Pain, Stroke…
Near Infrared Based Platform
Banu
Onaral, PhD
BIOMED
Kambiz
Pourrezaei, PhD
BIOMED
Guglielmo Foffani,
FUHNPAIIN
>>
To investigate the neurophysiological
effects
of manipulation of
cortical
excitability by
Transcranial
direct current stimulation (
tDCS
) device
Anna C. Merzagora, PhD Student
BIOMED
Antonio Oliviero
FUHNPAIIN
Slide29WWW.BIOMED.DREXEL.EDU
Banu Onaral
3141 Chestnut StreetPhiladelphia, PA 19104Phone: 215-895-2215Fax: 215-895-4983
Email: banu.onaral@drexel.edu
Thank you!
Slide30Human
Performance Assessment
Safe & Effective
Piloting
Air Traffic Controller
Cognitive Workload Monitor
UAV Ground Operator
Training and Workload Monitor
Pilot
Expertise Development Monitor
Brain Activity
Monitor
Crew can
manage & maintain
high levels of cognitive information processing
Portable brain imaging technology
can “bring more of brain on
task”*
Safe & effective performance
*DARPA: Dylan
Schmorrow
,
Ph.D. LCDR
, MSC, US
Navy, Program
Manager, ITO
Slide31Air Traffic Controller
FAA Next
Generation Air Transportation System (NextGen) StudySimilar to SESAR (Single European Sky ATM Research) Program
ATC part-task
Communication type:
Voice
Comm
and Data
Comm
Workload manipulated by number of aircrafts in the sector: n= 6,12,18
16-channel fNIR sensor
Slide32UAV Safe Piloting
Integration of the functional brain monitoring system with
training procedures
ground control systems
objective measure of
expertise level
to validate adequate training
real-time monitor of
mental workload
safe operation of UAVs…
US Army Medical Research and Materiel Command (USAMRMC)
The Telemedicine & Advanced Technology Research Center (TATRC)