OMICS Group OMICS Group International through its Open Access Initiative is committed - PowerPoint Presentation

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OMICS Group

OMICS Group International through its Open Access Initiative is committed to make genuine and reliable contributions to the scientific community. OMICS Group hosts over

400

leading-edge peer reviewed Open Access Journals and organizes over

300

International Conferences annually all over the world. OMICS Publishing Group journals have over

3 million

readers and the fame and success of the same can be attributed to the strong editorial board which contains over

30000

eminent personalities that ensure a rapid, quality and quick review process. OMICS Group signed an agreement with more than

1000

International Societies to make healthcare information Open Access.

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OMICS Journals are welcoming Submissions

OMICS Group welcomes submissions that are original and technically so as to serve both the developing world and developed countries in the best possible way.

OMICS Journals are poised in excellence by publishing high quality research. OMICS Group follows an Editorial Manager® System peer review process and boasts of a strong and active editorial board.Editors and reviewers are experts in their field and provide anonymous, unbiased and detailed reviews of all submissions.The journal gives the options of multiple language translations for all the articles and all archived articles are available in HTML, XML, PDF and audio formats. Also, all the published articles are archived in repositories and indexing services like DOAJ, CAS, Google Scholar, Scientific Commons, Index Copernicus, EBSCO, HINARI and GALE.For more details please visit our website: http://omicsonline.org/Submitmanuscript.php

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Dr

Y. Guillaume Aboua Cape Peninsula University of Technology

PO Box 1906,   Bellville 7535, South AfricaFaculty of Health & Wellness Sciences Department of Biomedical SciencesReproductive BiologyabouaY@cput.ac.zaTel: 021 959 6983

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1.Reactive Oxygen Species and Sperm Function

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BackgroundMany environmental, physiological, and genetic factors have been shown to impair sperm function through oxidative damage. Oxidative stress (OS) arises as a consequence of excessive reactive oxygen species (ROS) production and/or impaired antioxidant defence

mechanisms. The decline in male reproductive health has generated considerable public and scientific concerns about the possible role of environmental contaminants. A better understanding of how OS affect sperm function will be beneficial as it might help in the design of new and effective treatment strategies to combat the problem of increasing male subfertility.

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2.Reactive Oxygen Species, Oxidative Stress and male infertility

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BackgroundDespite the vulnerability of sperm to oxidative stress, it is also clear that normal sperm function depends on low levels of ROS generation in order to promote the

transduction signal pathways associated with capacitation. Modulators of ROS generation by spermatozoa may therefore have clinical utility in regulating the fertilizing capacity of these cells and preventing the development of anti-sperm immunity. The mechanisms by which oxidative stress limits the functional competence of mammalian spermatozoa involve the peroxidation of lipids, electron leakage from the sperm mitochondria, the induction of oxidative DNA damage, and the formation of protein adducts.

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3. Measurement of ROS generation by

human spermatozoa

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A variety of techniques have been developed for this purpose including chemiluminescence (luminol and

lucigenin), flow cytometry (MitoSOX Red,

dihydroethidium, 4,5-diaminofluoresceindiacetate and 2′,7′-dichlorodihydrofluorescein diacetate) and spectrophotometry (nitroblue tetrazolium).ROS generation is triggered with a variety of reagents including 2-hydroxyestradiol, menadione, 4-hydroxynonenal and arachidonic acid.  

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Reproduced from

Aitken et al 2013

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4

. Diabetes mellitus: impact on male sexual function and infertility

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Background

DM basically impinges on the male reproductive system and fertility through its effects on

Erectile dysfunction (ED) Impaired semen parameters. The mechanisms via which DM can impact on infertility is Hyperinsulinemia Changes in reproductive hormonal levels

Oxidative

stress

Adipokines

Adipocyte

derived hormones such as

resistin

and

leptin

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5.

Potentials of Phytotherapeutic Treatment of Erectile Dysfunction (ED)

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BackgroundIt is often difficult to establish the exact etiology of ED, as it is frequently a secondary symptom of an underlying condition, the nature of which can be physical, psychological, or biochemical. Physical conditions include diseases

such as diabetes, renal failure, malaria, & cancer, as well as cardiovascular factors (hypertension, atherosclerosis and heart disease, all of which can also be associated with

life style factors (age, smoking, and drug / alcohol intake).

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SignificantPhytotherapeutic

drugs generally have a broad spectrum of action in the body, and are often capable of influencing virtually all metabolic processes with minimal side effects. Studies investigating the potential of phytotherapeutic treatments for ED are extremely limited.

Herbal therapies appear to have potential benefits, but the health risks of various phytotherapeutic compounds still need to be elucidated.

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6. Leukocytospermia and O

xidative Stress

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BackgroundThe invasion of microorganisms and infective bacteria in the genito-urinary tract leads to the rapid increase in white blood cells that can present in the

ejaculate.Inflammatory response, aimed at killing the microorganisms via the production and release of

pathological ROS levels leading to Oxidative Stress.Leukocytospermia (leukocyte concentration >106/ml semen ) is present in ±20% of male factor infertility.

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SignificanceLeukocytospermia

represents an additional risk factor that should be treated, especially when in vitro therapy is to be scheduled, in order to improve gamete quality. The

relationship between leukocytospermia, OS as well as possible treatment regimes are explored.

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7. Effects of Methamphetamine (MA) on male reproductive function

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BackgroundNicotine and Methamphetamine (MA) addiction are serious worldwide public health problems with many consequences and complications. Significant morbidity including cardiovascular, infectious, pulmonary, dental diseases and other system complications are associated with abuse of these substances.

Using a wistar

rat model, we are investigating the effects of chronic usage of MA on sexual beheviour and on male reproductive function.This study maight shed more light on the exact level of male spermatogenesis that is influenced by the exposure to Methamphetamine .

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8. Dietary antioxidants and male

infertility

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BackgroundAntioxidants are able to protect biological systems against the potentially harmful effects of processes or reactions that can cause excessive oxidation.

Different antioxidant protection systems play important and interdependent roles in reducing OS in

male reproductive function.Antioxidants mostly derived from the human diet maintain a healthy sperm production and can offer an alternative when managing male infertility because they are cost effective and have little or no side effects on male reproductive function.

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Andrology Related Journals

Related Journals

Journal of Pregnancy and Child HealthReproductive System & Sexual DisordersJournal of Women′s Health CareGynecology

&

Obstetrics

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OMICS Group

Open Access Membership

OMICS publishing Group Open Access Membership enables academic and research institutions, funders and corporations to actively encourage open access in scholarly communication and the dissemination of research published by their authors.For more details and benefits, click on the link below:http://omicsonline.org/membership.php

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International Conference on Women's Health, Gynecology & Obstetrics

2nd International conference on HIV/AIDS, STDs & STIs-2014

Andrology-Open Access JournalRelated Conferences