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Alcohol and your heart Beth A. Alcohol and your heart Beth A.

Alcohol and your heart Beth A. - PowerPoint Presentation

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Alcohol and your heart Beth A. - PPT Presentation

Kalicki Heli J Roy RD PhD Pennington Biomedical Research Center Key thoughts Several large studies show that alcohol consumption results in a Ushaped curve Both abstainers and heavy drinkers have ID: 747946

alcohol 2010 pbrc heart 2010 alcohol heart pbrc disease risk research consumption intake blood drinks pennington center health american

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Slide1

Alcohol and your heart

Beth A.

Kalicki

Heli

J. Roy, RD, PhD

Pennington Biomedical Research CenterSlide2

Key thoughts

Several

large

studies show that alcohol consumption results in a U-shaped curve. Both abstainers and heavy drinkers have higher mortality than moderate drinkers. Heavy drinking can result in deleterious effects such as cirrhosis of the liver, increased rates of cancer and accidents. Those that consume no or little alcohol, are at a higher risk of mortality from cardiovascular disease

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2Slide3

Key thoughts

Alcohol has both good and bad effects.

It can have good effects at small intake levels.

High intake can quickly lead to very harmful effects.

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Relative Risk of Mortality

Drinks/weekSlide4

Alcohol consumption and relative risk of death from heart disease and cancer

With increased alcohol consumption, the relative risk of mortality increases for cancer (red)

vs

heart disease (blue).

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4

Drinks/day

Relative risk of mortalitySlide5

Recommendations

Due to the U-shaped curve, the recommendations

for alcohol

intake are:Women – no more than 1 drink a day.Men – no more than 2 drinks a day. This recognizes the fact that alcohol has some protective effect on cardiovascular disease, but the risk for other diseases increases quickly with increased consumption. 3/12/2010

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5Slide6

Alcohol serving sizes

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Increases HDL (good) cholesterol (~ 12%)

Resveratrol

– prevents stickiness of platelets

Decreases risk of a heart attackReduces  risk of diabetesReduces risk of heart diseaseLowers risk of dementiaMay prevent silent strokesBenefits of moderate alcohol consumption

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Inhibits the constriction of the coronary arteries

limits clot formation

decreases levels of

homocysteineLowers rate of obesity

Benefits of moderate alcohol consumption

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There is a

change in biological markers

for

coronary heart disease. Alcohol increased concentrations of high density lipoprotein cholesterol, apolipoprotein A I, and triglyceride.A survey of research shows that an intake of 30 g of alcohol a day (two drinks) would

cause an estimated reduction of 24.7% in risk of coronary heart

disease. Alcohol intake

lowers the

risk of coronary heart disease through changes in

blood lipids

and

blood flow

factors.

BMJ

1999;319:1523-1528

Benefits of moderate alcohol consumption

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Men

reduced risk of heart attack and heart disease

Women

decreased

risk of

death from cardiovascular disease

Benefits of moderate alcohol consumption

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Pattern of alcohol consumption is important

Small amount daily is associated with better health and increased longevity

Consuming seven to fourteen drinks once a week is associated with negative health (binge drinking).

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> 3 drinks = direct toxic effect on the heart

High intake of alcohol results in

high blood pressure

high triglyceride levelscongestive heart failure alcoholic cardiomyopathy (enlarged and diseased heart) increased incidence of heart disease and stroke

Harmful effects of alcohol

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Binge drinking = more than 3 or 4 drinks in a short

time.

Increases risk of:

atrial fibrillation cardiac arrhythmia (irregular heart beat)Binge Drinking3/12/2010

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Can lead to:

weakening of heart muscle

hemorrhagic stroke

cirrhosis of the liver pancreatitis certain cancers trauma

suicide

homicide

Excessive alcohol intake

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Excessive alcohol intake

Long term excessive alcohol

use:

irreversible brain damage impaired thinking unsteady walkslowed speechThese results are irreversible even if a person discontinues alcohol consumption.

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15Slide16

The American Heart Association recommends

that you do not consume alcohol if you have:

Personal or strong family history of alcoholism.

Uncontrolled high blood pressureHigh blood triglyceride levelsPancreatitis

Liver disease

Porphyria

Heart Failure

Pregnancy

Are using medications that can have adverse reactions with alcohol.

When not to consume alcohol

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The American Heart Association recommends traditional methods for preventing heart disease. These include:

Consuming a healthy diet

Exercising

Controlling blood cholesterolRemaining a healthy weightControlling blood pressure within normal ranges

Recommendations by the American Heart Association

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Normal Heart vs. Alcoholic Heart

The Enlarged Heart of an Alcoholic

A Normal Size Human Heart

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Pennington Biomedical Research Center

Authors:

Beth A. Kalicki

Heli J. Roy, RD, PhD

Division of Education

Phillip Brantley, PhD, Director

Pennington Biomedical Research Center

Steven

Heymsfield

, MD,

Executive Director

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About Pennington

The Pennington Biomedical Research Center is a world-renowned nutrition research center.

Mission:

To promote healthier lives through research and education in nutrition and preventive medicine.

The Pennington Center has several research areas, including:

 Clinical Obesity Research

Experimental Obesity

Functional Foods

Health and Performance Enhancement

Nutrition and Chronic Diseases

Nutrition and the Brain

Dementia, Alzheimer’s and healthy aging

Diet, exercise, weight loss and weight loss maintenance

The research fostered in these areas can have a profound impact on healthy living and on the prevention of common chronic diseases, such as heart disease, cancer, diabetes, hypertension and osteoporosis.

 

The Division of Education provides education and information to the scientific community and the public about research findings, training programs and research areas, and coordinates educational events for the public on various health issues.

 

We invite people of all ages and backgrounds to participate in the exciting research studies being conducted at the Pennington  Center in Baton Rouge, Louisiana. If you would like to take part, visit the clinical trials web page at www.pbrc.edu or call (225) 763-3000.

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References

American Heart Association. (2009). Alcohol, Wine, and Cardiovascular Disease.

Alcohol Cardiovascular Disease

. Retrieved August 12, 2009, fromhttp://www.americanheart.org/

print_presenter.jhtml?identifier=4422Johns Hopkins Medicine. (2005). Alcohol and Heart Attacks: Does a Drink a Day Lower Your Risk?

Health Alerts

. Retrieved August 12, 2009, from http://www.johnshopkinshealthalerts.com/reports/

heart_health

/265-1.html?type=

pf

Women’s Heart Foundation. (2007). Alcohol and Heart Disease.

Heart Disease.

Retrieved August 12, 2009, from

http://www.womensheart.com/content/HeartDisease/

alcohol_and_heart_disease.asp

Breslow

, R.A., and Smothers, B.A. Drinking pattern and body mass index in never smokers: National Health Survey, 1997-2001.

American Journal of Epidemiology

, 2005,

161(4)

, 368-376.

Liu B, et al "Body mass index and risk of liver cirrhosis in middle aged UK women: prospective study"

BMJ

2010; DOI: 10.1136

Wall TL, Carr CG, and Ehlers

CL.Protective

Association of Genetic Variation in Alcohol

Dehydrogenase

With Alcohol Dependence in Native American Mission Indians .

Am J Psychiatry 160:41-46, January 2003

.

Forn-Frías C,

Sanchis

-Segura C.

The possible role of acetaldehyde in the brain damage caused by the chronic consumption of alcohol. Rev Neurol. 2003 Sep 1-15;37(5):485-93.

National Institute on Alcohol Abuse and Alcoholism. NIH. Alcohol Alert. No 72, July 2007.

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