/
Families & Heart Failure - Families & Heart Failure -

Families & Heart Failure - - PowerPoint Presentation

myesha-ticknor
myesha-ticknor . @myesha-ticknor
Follow
435 views
Uploaded On 2016-03-22

Families & Heart Failure - - PPT Presentation

What Role does genetics play April 1 st 2013 Heart Failure Education Series David N Edwards MD PhD FACC Advanced Heart Care PA The Heart Hospital Baylor Plano Family History ID: 265169

disease heart genetics cardiomyopathy heart disease cardiomyopathy genetics dilated cardiac family failure dcm blueprint patients arvd history risk due

Share:

Link:

Embed:

Download Presentation from below link

Download Presentation The PPT/PDF document "Families & Heart Failure -" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.


Presentation Transcript

Slide1

Families & Heart Failure -What Role does genetics play?

April 1st, 2013Heart Failure Education Series

David N.

Edwards, M.D. Ph.D. F.A.C.C.

Advanced Heart Care, PA

The Heart Hospital Baylor PlanoSlide2

Family HistoryStandard part of medical clinic visitTendencies

AgesEarly or unusual eventsSlide3

Genetics of Cardiovascular Disease:Family History is ImportantTwo copies of every blueprint.

One from mom.One from dad.A gene is the blueprint for a protein.Proteins do the work – structure, channels, controls.

One typo in one blueprint can cause disease.Slide4

Family HistoryCommon geneticsHigh blood pressureCoronary disease

Atrial fibrillationRare geneticsDilated cardiomyopathyHypertrophic cardiomyopathy

ARVDSlide5

Cardiac Structural DiseaseSlide6

“Typo” in the Myofilament InstructionsSlide7

CHF – Congestive Heart Failure Heart can be either too thick or too thin – or too stiff.Symptoms are due to inability to pump efficiently.

Vast majority of CHF patients have dilated cardiomyopathy (DCM)Slide8

Dilated Cardiomyopathy (DCM)Prevalance – 36 patients per 100,000 population.

Most are ischemic – due to plumbing problems.Others are still explainable.Non-ischemicRemaining were called “idiopathic”.

From genedx.com website.Slide9

Unknown cause?Between 20 and 50% of idiopathic cardiomyopathy is now thought to be inherited.

15% of middle age and older adults have dilated cardiomyopathy with no symptoms.Slide10

Sudden Death in the Young80-85% cardiac, 15-20% non-cardiac.

Primary electrical disease: LQTS, Brugada, ARVD/C, CPVT, WPW, congenital conduction system disease.Unrecognized structural heart disease: HCM, DCM, ARVD/C, myocarditis, congenital anomalies (heart and coronary arteries), CAD.

Non-cardiac causes:

Aortic rupture, cerebral hemorrhage, pulmonary embolus, respiratory failure.Slide11

Copyright © The American College of Physicians. All rights reserved.

From: Sudden Cardiac Death: Epidemiology, Transient Risk, and Intervention Assessment

Ann Intern Med.

1993;119(12

):1187-1197. doi:10.7326/0003-4819-119-12-199312150-00006Slide12

(Heart Rhythm 2011; 8:1308 –1339)

For dilated cardiomyopathy:Class IIa (can be useful)-

Genetic testing

can be useful for patients with familial DCM to confirm the diagnosis, to recognize those who are at highest risk of arrhythmia and syndromic features,

to facilitate cascade screening within the family, and to help with family planning.Slide13

From genedx.com website.Slide14

Dedicated CV Genetics Clinics in the U.S. Staffed by Genetics Counselors