PPT-Systemic Therapy for Breast Cancer

Adjuvant or Neoadjuvant Agustin A Garcia MD MMM Professor of Medicine and Section Chief Hematology Oncology Charles W McMullin III and Richard Paul Grace Chair in Cancer Research Louisiana State University. A sub-focus on specific clinical scenarios. What to talk about?. Brain Metastatic Disease. CKD inhibition. HDAC inhibition. Androgen Receptor inhibition. mTOR. inhibition. Checkpoint Inhibition . Case Study. Cancer-Treatment-Induced Bone Loss (CTIBL). Clodronate and Bone Mineral Density (. Hip. ). Bone Mineral Density Substudy --ABCSG-12: Effect of Zoledronic Acid. Percent Change, Lumbar Spine. Denosumab for CTIBL (. Christy A Russell, MD. Keck School of Medicine. University of Southern California. Hazard Rate of Relapse. According to Tumor Subtype and Year of Diagnosis. British Columbia Population-Based Data. 1986-1992. Targeting endocrine-resistance pathways in breast cancer Clara Natoli, Chieti Endocrine responsive breast cancer Luminal A High expression of ER & ER-related genes Lower Antonella Brunello . Kwok-Leung Cheung. Disclosure. No . conflict. of . interests. Learning objectives. To . discuss the pros and cons of adjuvant chemotherapy for breast cancer in the elderly. To . RISK FACTORS FOR BREAST CANCER. Family . Hx. .: first- . and second-degree relatives with breast cancer and their age at diagnosis. .. RISK FACTORS FOR BREAST . CANCER . (. cont.). . Hormonal . Risk Factors. Cleveland Clinic Florida. Breast Surgeon . September 25, 2018. Breast Cancer . Highly prevalent disease . Limited to female sex in all but < 1% of cases in USA. SEER . Cancer. . Stat Facts: Female Breast Cancer. Rajiv Doddamani. . PGY – 3, Internal Medicine . . St. Joseph Mercy Ann Arbor . Learning objectives . Explain the principles of breast cancer screenings . group. of diseases. . All forms of cancer cause cells in the body to change and grow out of control. . Most types of cancer cells form a lump or mass called a . tumor. . . The tumor can invade and destroy healthy tissue. Cells from the tumor can break away and travel to other parts of the body. There they can continue to grow. . Breast Cancer in the US . Breast Cancer is estimated to affect . over 230,000 . women . annually in the US. Based on SEER Database rates from 2009-2011, the . cumulative lifetime risk. of an average woman in the general US population is 12.3%. Azeez Farooki, MD. Attending Physician, Clinical Member. Memorial Sloan Kettering Cancer Center. New York, NY. Objectives. Elucidate the problem of aromatase inhibitor induced bone loss and increased risk of fractures in breast cancer. . Breast Cancer | . Epidemiology- Australia. Australian Institute of Health and Welfare 2014. ACIM (Australian Cancer Incidence and Mortality) Books. Canberra. AIHW. Overall is the third leading cause of cancer.  breast tissue, . most . commonly from the inner lining . of.  milk ducts or the lobules that supply the . ducts . with . milk.. Breast cancer may be invasive or noninvasive. . Invasive. Jo Anne Zujewski, M.D.. June 2019. Thimphu. , Bhutan. Define the breast cancer. Is the cancer operable?. Stage 1: systemic therapy after surgery (and radiation if breast conservation). Stage 2: systemic therapy before or after therapy.