PPT-Weekly GLP1 Receptor Agonists

Major Metabolic Defects in Type 2 Diabetes Physiopathology of diabetes includes multiple metabolic defects14 Progressive βcell failuredecreased insulin secretion Insulin resistance α. DRUGS. Sympathetic nervous system is activated in case of stress.. Nor-adrenaline act as neurotransmitter. Adrenaline act as hormone released from adrenal medulla.. Distribution of Adrenoceptor Subtypes. นพ. . สโรจน์. . ศิ. ริ. มะณี. วัฒนา. ภาควิชาวิสัญญีวิทยา. ศูนย์การแพทย์ปัญญา. นันท. Pharmacology 49.222. Bill Diehl-Jones RN, PhD. Faculty of Nursing and Department of Zoology. Agenda. A Zen Review. Overview of CNS and ANS. Neurotransmitters and 2. nd. Messengers. Cholinergic Agonists and Antagonists. Cholinergic Agonists Direct-Acting Cholinomimetics Direct-Acting Cholinergic Agonists (N & M) Cholinergic agonists (parasympathomimetics) mimic the effects of ACh on cholinoceptors. These agents broadly classified into GnRH. GnRH Pathway. Pulsatile GnRH. Need of GnRH Analogues. Rapidly . degraded by peptidase and cleared by glomerular filtration. . T. 1/2. . is 2 to 4 . minutes. 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 1. 2. Anna Maria Nardiello. 1,. *, Lucia Sessa. 1,2. , Jacopo Santoro. 1. and Stefano Piotto. 1,2. 1. . Department of Pharmacy, University of Salerno, . Fisciano. , 84084, Italy. 2. . Research. Centre for . Graded Dose-response Relationships. Agonist . drugs mimic the action of the original endogenous ligand for the receptor (for example, isoproterenol mimics norepinephrine on β1 . receptors . of the heart). The magnitude of the drug effect depends on the drug concentration at the receptor site, which, in turn, is determined by both the dose of drug administered and by the drug’s pharmacokinetic profile, such as rate of absorption, distribution, metabolism, and elimination. body fat and enhanced growth in cattle (Ricks et al., 1984), sheep (Baker et al., 1984; Beermann et al., 1987), and swine (Jones et al., 1985). To achieve these effects it is necessary to use doses th Lispro 5-15 Hrs 1-2 4-5 NPH 1-2 Hrs 5-7 13-18 Lente 1-3 Hrs 4-8 13-20 Ultralente 2-4 Hrs 8-10 18-30 INT. J. DIAB. DEV. COUNTRIES (2000), VOL. 20 oxidation are also reduced by metformin. Metformin JNMC, AMU. Management of Bronchial Asthma. Introduction. . Asthma is a . chronic inflammatory disorder . of the airways that is . characterized:. clinically. . by. recurrent episodes of wheezing, breathlessness, chest tightness, and cough, particularly at night / early morning. . ain. The. . Pain. . Pathway. 1.) . Peri. ph. eral. nociceptors. bradykinin, substance P, histamine, acetylcholine, serotonin, ↓ pH (H. +. ), . prostaglandins . (inflammatory mediators). 2.) . Primary afferent . Graded Dose-response . Relationships:. Agonist drugs mimic the action of the original endogenous ligand for the receptor (for example, isoproterenol mimics norepinephrine on β1 receptors of the heart). . Disorders of Respiratory Function . Classification. . Main disorders of the respiratory system are :. 1. Bronchial asthma. 2. Cough. 3. Allergic rhinitis. 4. Chronic obstructive pulmonary disease. (COPD, also called emphysema). By. Hala. . Aqeel. Shams. M.B.Ch.B. /MSc. Clinical pharmacology. . Pharmacodynamics . describes the actions of a . drug. on the body. . Most drugs exert their . effects, . by interacting with . receptors.