PPT-“Weighing” in on GLP-1 Receptor Agonists

for People With HIV Suman Srinivasa MD MS Massachusetts General Hospital Harvard Medical School Boston MA Financial Relationships With Ineligible Companies Formerly Described as Commercial Interests by the ACCME Within the Last 2 Years. Teaser. Zak Fallows. 2013-07-03. http://datb.mit.edu. pharmacology@mit.edu. 1. How the Brain Works. You have about 100 billion brain cells, which are called neurons.. Each neuron has about 1,000 connections, called synapses. (This number is extremely variable.). Pharmacodynamics. Pharmacodynamics. The study of the biochemical and physiologic effects of drugs and the molecular mechanisms by which those effects are produced . The study of what drugs do to the body and how they do it . นพ. . สโรจน์. . ศิ. ริ. มะณี. วัฒนา. ภาควิชาวิสัญญีวิทยา. ศูนย์การแพทย์ปัญญา. นันท. Pharmacology 49.222. Bill Diehl-Jones RN, PhD. Faculty of Nursing and Department of Zoology. Agenda. A Zen Review. Overview of CNS and ANS. Neurotransmitters and 2. nd. Messengers. Cholinergic Agonists and Antagonists. ) effects on CB1 Inverse Agonists. Erin Cochran. Endocannabinoid System. Pharmacology Terms. Basal. or . Constitutive. . activity-. . physiological response . in . the absence of an agonist or inverse . Nervous System. Part 2. . Thomas E. Tenner, Jr., Ph.D.. Dept. of Medical Education. Dept. Pharmacology & Neuroscience. tom.tenner@ttuhsc.edu. 743-7169. 1. Recommended Background Reading :.  . Chapters 7, 8, 9, and 10 . Dr. Fatimah . Almahasneh. Department of Basic Medical Sciences. Yarmouk. University . Contents. Anterior pituitary gland. Growth hormone (GH). Prolactin. Posterior pituitary gland. Vasopressin. 2. Introduction. Pain. . Pain. persists Pain persists. or increases or increases. 1. . Non. -. opioid. ± adjuvant. 2. Weak . opioid. ± non-. opioid. ± adjuvant. 3. Strong . opioid. Graded Dose-response Relationships. Agonist . drugs mimic the action of the original endogenous ligand for the receptor (for example, isoproterenol mimics norepinephrine on β1 . receptors . of the heart). The magnitude of the drug effect depends on the drug concentration at the receptor site, which, in turn, is determined by both the dose of drug administered and by the drug’s pharmacokinetic profile, such as rate of absorption, distribution, metabolism, and elimination. PHL 313 Lab. . . 3. 2. 3. Adrenergic Receptors . α. 1. receptor. vasoconstriction . blood pressure . α. 2. receptor. inhibit release of . (nor-epinephrine) . negative feed-back . 4. β. 1. receptor. Lispro 5-15 Hrs 1-2 4-5 NPH 1-2 Hrs 5-7 13-18 Lente 1-3 Hrs 4-8 13-20 Ultralente 2-4 Hrs 8-10 18-30 INT. J. DIAB. DEV. COUNTRIES (2000), VOL. 20 oxidation are also reduced by metformin. Metformin Pharmacodynamics. Dennis Paul, Ph.D.. dpaul@lsuhsc.edu. Learning Objectives:. Understand the theoretical basis of drug-receptor interactions.. Understand the determinants and types of responses to drug-receptor interactions.. Graded Dose-response . Relationships:. Agonist drugs mimic the action of the original endogenous ligand for the receptor (for example, isoproterenol mimics norepinephrine on β1 receptors of the heart). . By. Hala. . Aqeel. Shams. M.B.Ch.B. /MSc. Clinical pharmacology. . Pharmacodynamics . describes the actions of a . drug. on the body. . Most drugs exert their . effects, . by interacting with . receptors.