Pharmacodynamics (cont.)

Graded Doseresponse Relationships Agonist drugs mimic the action of the original endogenous ligand for the receptor for example isoproterenol mimics norepinephrine on β1 receptors of the heart The magnitude of the drug effect depends on the drug concentration at the receptor site which in turn is determined by both the dose of drug administered and by the drugs pharmacokinetic profile such as rate of absorption distribution metabolism and elimination

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