PPT-PHARMACODYNAMICS

DR NARENDRA KUMAR Pharmacodynamics is the study of the biochemical and physiological effects of drugs and their mechanisms of action Simply stated pharmacodynamics refers to the effects of a drug on the body. y.o. male. . Tries to jog 16 km in preparation to join an upcoming marathon.. Ibuprofen. Class: . NSAID (. Propionic. acid derivative) with analgesic and antipyretic properties. Indications: . Symptomatic treatment of arthritis (. & THERAPEUTICS . ESSENTIAL DRUG LIST . Alexandra Burke-Smith. 1. Drugs and the Autonomic Nervous System . Overview of the ANS . Sympathetic NS = “fight or flight”, Parasympathetic NS = “rest + digest”. NICOTINE ADDICTION. U.S. Surgeon General’s Report. Cigarettes and other forms of tobacco are addicting.. Nicotine is the drug in tobacco that causes addiction.. The pharmacologic and behavioral processes that determine tobacco addiction are similar to those that determine addiction to drugs such as heroin and cocaine.. of obstetric anesthesia . Dr SPS. 10/4/2015. 1. Dr. S. Parthasarathy MD., DA., DNB, . MD (. Acu. ), Dip. . Diab. . DCA, . Dip. Software statistics, . PhD (physiology) FICA . Mahatma Gandhi Medical College and Research Institute, . Graded Dose-response Relationships. Agonist . drugs mimic the action of the original endogenous ligand for the receptor (for example, isoproterenol mimics norepinephrine on β1 . receptors . of the heart). The magnitude of the drug effect depends on the drug concentration at the receptor site, which, in turn, is determined by both the dose of drug administered and by the drug’s pharmacokinetic profile, such as rate of absorption, distribution, metabolism, and elimination. and Protein Drugs . The central paradigm(. نموذج. ). of clinical pharmacology: The dose-concentration-effect relationship. Dose (mg/day) . pharmacokinetics. Concentration. (mg/l). Efficacy . Toxicity. Mycobacteria tuberculosis . DNA gyrase inhibitors . EMMANUEL MOYO. Treatment is lengthy and complex. Treatment for drug susceptible TB is 6 month course . - Isoniazid, Rifampicin, Ethambutol and Pyrazinamide. A further cohort . of rabbits received amikacin 3.33mg/kg q8h . i.v.. or 5mg/kg . i.v.. q8h in combination with meropenem 5mg/kg . s.c.. q8h. Although this had minimal additional effect on the total bacterial population, the emergence of a meropenem-resistant population was suppressed compared to monotherapy. Graded Dose-response . Relationships:. Agonist drugs mimic the action of the original endogenous ligand for the receptor (for example, isoproterenol mimics norepinephrine on β1 receptors of the heart). . By. Hala. . Aqeel. Shams. M.B.Ch.B. /MSc. Clinical pharmacology. . Pharmacodynamics . describes the actions of a . drug. on the body. . Most drugs exert their . effects, . by interacting with . receptors.