PPT-Drug Receptors &

Pharmacodynamics Seyed Ali Ziai Receptor Pharmacologic antagonists Macromolecular Nature of Drug Receptors Regulatory proteins Enzymes Transport proteins Structural proteins Receptor Effector Coupling. By Poppy and Jake. Intracellular receptors. Where are they?. What binds to them?. Intracellular (duh). Some are in the cytoplasm and some are in the nucleus.. Lipophillic. and hydrophobic ligands. E.g. Steroids (sex and . What are receptors and effectors and to what do they respond? . Starter. :. What are the 5 senses.. What are the stimuli for these?. What detect the stimuli?. Stimulus: a change in the environment that causes a response.. Department of Biochemistry. GITAM UNIVERSITY. India. Editorial Board Member. Journal . of Marine Science: Research & Development. Journal of Marine Science: Research & Development. ISSN: 2155-9910. A Selective Overview. Carl Rosow, M.D., Ph.D.. Disclosures. Consultant – Salix Pharmaceuticals. Topics for Today. Pharmacodynamics. Receptors, potency, efficacy. Agonists, antagonists. The dose response curve. Evan M. Peck and Bradley D. Smith. *. Department of Chemistry and Biochemistry, . 236 . Nieuwland. Science Hall, . University . of Notre Dame, . Notre . Dame, 46556 IN, . USA. . *Email. : smith.115@nd.edu. Receptor. A receptor is a protein molecule usually embedded within the cell membrane with part of its structure exposed on the outside of the cell.. The protein surface is a complicated shape containing hollows, ravines, and ridges.. Drug abuse . is . inappropriate. and usually . excessive. , . self-administration. of a . psychoactive . drug for . non-medical purposes.. Almost all abused drugs exert . their effects in the CNS . Kuby Immunology. , . 7e: Chapter 3. Essential Concepts – 1. A cellular signal is any event that instructs a cell to change its metabolic or proliferative state. Signals are usually generated by the binding of a ligand to a complementary cell-bound receptor. Exercise 20. BI 232. Introduction and Terminology. There are many types of sense receptors in the body.. They are not uniformly distributed. Punctate. distribution . is the pattern of uneven distribution throughout the body. ACH is synthesized in the cholinergic neurons from choline and acetyl CoA then stored in synaptic vesicles then it will be release into synaptic gap to bind post synaptic receptors and lead to biological response.. inappropriate. and usually . excessive. , . self-administration. of a . psychoactive . drug for . non-medical purposes.. Almost all abused drugs exert . their effects in the CNS . causing. euphoria or alter perception.. 1 Beta - blockers have been widely used in the management of angina, certain tachyarrhythmias and heart failure, as well as in hypertension . Examples Acebutolol Atenolol Bisoprolol Carvedilol Celip Pharmacodynamics. D-R Interact.ions and Pharmacodynamics. Pharmacodynamics. . Describes the actions of drugs on the body and the influence of drug . concentration on the magnitude of the response. . by . Dr.Vani. Gupta. Homeostasis. Homeostasis. - maintaining internal stability within an organism and returning to a particular stable state after a fluctuation..