PPT-Receptors and Signaling: B- and T-Cell Receptors

Kuby Immunology 7e Chapter 3 Essential Concepts 1 A cellular signal is any event that instructs a cell to change its metabolic or proliferative state Signals are usually generated by the binding of a ligand to a complementary cellbound receptor. Main receptors. -. αβ. (Alpha &beta). - . γδ. (Gamma& delta). Co-receptors. -CD4&CD8 molecules. Co-stimulatory receptors. -CD28. Signal transduction molecules. -e, g, d . and . z. chains. . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Pharmacodynamics. Seyed. Ali . Ziai. Receptor. Pharmacologic antagonists. Macromolecular Nature of Drug Receptors. Regulatory proteins. Enzymes. Transport proteins . Structural proteins. . Receptor- Effector Coupling. Receptor. A receptor is a protein molecule usually embedded within the cell membrane with part of its structure exposed on the outside of the cell.. The protein surface is a complicated shape containing hollows, ravines, and ridges.. Control of the Cell Cycle. Intracellular signaling. Pathways initiated by ligand binding to receptors, usually plasma membrane proteins. Modulate cell growth, metabolism, death, differentiation, movement, and invasion. Signal Receptors. . BIOL 5190/6190 Cellular & Molecular . Singal. Transduction. Prepared by Bob Locy. Last modified -13F. Intracellular Signal Receptors. Steroid hormone receptors. . Other . Lipophillic. AND . MOTILITY (BIOL 3373) . WHAT IS The CELL SIGNALING?. 2. How cells receive and respond to signals from their surroundings. On one hand, cell signaling regulates gene expression and controls the cell fate (proliferation, motility, differentiation and programmed cell death, or apoptosis).. Learning Objectives. Learn the general structure and properties of hormones.. Know the differences between Hormones, Neurotransmitters & enzymes. 3. . Understand . the general properties of signaling molecules (ligands), cell-surface receptors, & intracellular signal transduction components.. Introduction. Cell signaling: . a biological mechanism that occurs in cells which gives cells an ability to receive or generate the signals in response to their surrounding environment.. Cell to cell communication . GPCR STRUCTURE AND FUNCTION G-protein-coupled receptors (GPCRs) or seven transmembrane domain receptors (7TM) comprise the largest superfamily of proteins in the body. In 6 Figure 1: Diversity Dr. Mohammed Hussein. M.B.Ch.B, MSC, . PhD, MRCPCH. , DCH (UK). Cellular Communication and Signaling. Types of Signaling. Autocrine. Direct . Signaling. Paracrine. Endocrine. Autocrine Signaling. Autocrine Signaling. Alzayadneh. , PhD. Integrative Physiology and Pharmacology. 1. Introduction to Physiology (0501110) Spring 2013. Subject. Lecture No.. Lecturer. Pages in the 11. th. edition. textbook. Pages in the 12. . by . Dr.Vani. Gupta. Homeostasis. Homeostasis. - maintaining internal stability within an organism and returning to a particular stable state after a fluctuation.. PowerPoint Image Slideshow. This work is licensed under a . Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. .. Communication. As with people, it is vital for individual cells to be able to interact with their environment. In order to properly respond to externals stimuli, cells have developed complex mechanisms of communication that can receive a message, transfer the information across the plasma membrane, and produce changes within the cell in response to the message. The ability of cells to communicate through chemical signals originated in single cells and was essential for the evolution of multicellular organisms. (credit: modification of work by Vincent and Bella Productions).