PPT-Structure activity relationship (SAR)of sympathomimetic amines, Adrenergic antagonist

Structure activity relationship SARof sympathomimetic amines Adrenergic antagonist and Neurone blockers Dr ISHOLA IO PHARMACOLOGY THERAPEUTICS AND TOXICOLOGY CMUL INTRO Phenylethylamine can viewed as parent compound NA AD DA ISOP. and . Drug Ingestions. Toxidromes. What is a Toxidrome?. . A constellation of clinical signs that may suggest a particular type of ingestion. Toxidromes may indicate what type of drugs a patient has taken if they are unable or unwilling to tell you. The painkiller morphine is obtained from opium, the dried sap of unripe seeps of the poppy . P. apaver. . somniferum. Amines are relatives of ammonia and are usually classified as primary, secondary or tertiary. β-adrenergic antagonists are commonly used to treat hypertension, angina, tremor, migraine, and panic attacks.. ACTION. β-adrenergic antagonists competitively antagonize the effects . of . catecholamines. ADRENERGIC RECEPTORS. . . α. 1. . α. 2. -Postsynaptic . Presyn. . (periphery). - Sm. M of peripheral B.V. - ↓ NT release . By Linda Self. NUR 3703. Divisions of human nervous system. Nervous system. Sympathomimetic or adrenergic in sympathetic nervous system—neurotransmitters are ____________. Parasympathomimetic or cholinergic are used to describe parasympathetic system—neurotransmitter is _____________. DR. ISHOLA I.O.. DEPT OF PHARMACOLOGY, THERAPEUTICS AND TOXICOLOGY. CMUL. ADRENERGIC TRANSMISSION. Adrenergic transmission is restricted to the sympathetic nervous system. Norepinephrine. is the transmitter at post-ganglionic sympathetic nerves – except sweat glands . 3. . Amines can be classified as primary, secondary or tertiary. . Primary amines . have one carbon attached to the nitrogen atom of the amine group. . Secondary amines . have two carbons attached to the nitrogen atom of the amine functional group. . Know what amines are and some reactions of amines. Outcomes:. Identify amines. Explain . the reactions of primary aliphatic amines, using . butylamine. as . an example. , with. : water . to form an alkaline . Classification of amines. Nomenclature of amines. Physical Properties of amines. Preparation of amines. Reaction of amines. 2. By the end of this chapter the student . will know:. Learning. . Objectives. Sympatholytics. ). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. These . Motor Neurone Disease (MND) is an uncommon disease that affects the brain and nerves. In MND your motor nerves become damaged and eventually stop working and you gradually lose your strength . There is currently no cure for Motor Neurone Disease . spinal cord. muscle (effector). pain receptors. AQA GCSE HOMEOSTASIS AND RESPONSE part 1. Information from receptors passes along cells (neurones) as electrical impulses to the central nervous system (CNS). Objectives. Discuss the pharmacology of . catecholamines. Classify & describe adrenergic α-agonists including actions, therapeutic uses & adverse. reactions.. Classify & describe adrenergic β-agonists including actions, therapeutic uses & adverse. muscarinic. antagonist / . muscarinic. blocker.. OBJECTIVES. Classify & describe cholinergic antagonists. Explain actions, therapeutic uses & adverse reactions of cholinergic antagonists. Cholinergic antagonist / Cholinergic blockers.