PPT-Structure activity relationship (SAR)of sympathomimetic amines, Adrenergic antagonist

Structure activity relationship SARof sympathomimetic amines Adrenergic antagonist and Neurone blockers Dr ISHOLA IO PHARMACOLOGY THERAPEUTICS AND TOXICOLOGY CMUL INTRO Phenylethylamine can viewed as parent compound NA AD DA ISOP. Dr. . Sheppard. CHEM . 2412. Summer 2015. Klein (2. nd. ed. .) . sections: 23.1, 23.2, 23.3, 23.13, 23.4,. . . 23.5, 23.6, 23.8. Amines. Derivatives of ammonia. Neurotransmitters. Medicines. Introduction. Autonomic . nervous system (. ANS). A. utomatic. , self-governing, or . involuntary. No . conscious . control. Divided . into . sympathetic (alert system) and . parasympathetic nervous . Def: The ANS consists of all visceral motor neurons innervating smooth muscle, cardiac muscle and glands.. Divide Autonomic Pharmacology into Four Categories:. 1. Drugs that increase the sympathetic nervous system response . By Linda Self. NUR 3703. Divisions of human nervous system. Nervous system. Sympathomimetic or adrenergic in sympathetic nervous system—neurotransmitters are ____________. Parasympathomimetic or cholinergic are used to describe parasympathetic system—neurotransmitter is _____________. Classify adrenergic antagonists . Describe actions, therapeutic uses & adverse effects of adrenergic antagonist.. b. Discuss the role of autonomic drugs in central nervous system disorders. c. Enlist drugs used in glaucoma. 3. . Amines can be classified as primary, secondary or tertiary. . Primary amines . have one carbon attached to the nitrogen atom of the amine group. . Secondary amines . have two carbons attached to the nitrogen atom of the amine functional group. . Know what amines are and some reactions of amines. Outcomes:. Identify amines. Explain . the reactions of primary aliphatic amines, using . butylamine. as . an example. , with. : water . to form an alkaline . Adrenergic . Agents. Assist . Prof . Karima F. Ali. AL-Mustansiriyah university. College of pharmacy. Adrenergic drugs. . exert their principal pharmacological . and therapeutic . effects by either enhancing or reducing . Calcium Channel Blocker. WASU TACHAWATTANAKUL, M.D.. Objective. Pharmacologic properties of beta-adrenergic antagonist & calcium channel blocker. Clinical manifestation. Management & Antidote. Classification of amines. Nomenclature of amines. Physical Properties of amines. Preparation of amines. Reaction of amines. 2. By the end of this chapter the student . will know:. Learning. . Objectives. Sympatholytics. ). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. These . Amines. may be considered as derivatives of ammonia, NH. 3. , in which . an alkyl or aryl group. has replaced one or more of the . hydrogen. . . Those . amines . that carry only alkyl groups are classified as . ). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. These are drugs which mimic the effects of sympathetic stimulation or those of . muscarinic. antagonist / . muscarinic. blocker.. OBJECTIVES. Classify & describe cholinergic antagonists. Explain actions, therapeutic uses & adverse reactions of cholinergic antagonists. Cholinergic antagonist / Cholinergic blockers.