PPT-β-adrenergic antagonists

βadrenergic antagonists are commonly used to treat hypertension angina tremor migraine and panic attacks ACTION βadrenergic antagonists competitively antagonize the effects of catecholamines. Adrenergic Antagonists. Adrenergic Antagonists. Cause direct blockade of adrenergic receptors. With one exception, all produce reversible (competitive) blockade. Most adrenergic antagonists are more selective than the adrenergic agonists.. Chapter 13, . Stryer. Short Course. Signal Transduction. Signal from exterior of cell must affect interior of cell. Through the membrane. Amplification of signal. Ability to turn off. A few pathways…. β-adrenergic antagonists are commonly used to treat hypertension, angina, tremor, migraine, and panic attacks.. ACTION. β-adrenergic antagonists competitively antagonize the effects . of . catecholamines. ADRENERGIC RECEPTORS. . . α. 1. . α. 2. -Postsynaptic . Presyn. . (periphery). - Sm. M of peripheral B.V. - ↓ NT release . OBJECTIVES. 1. Know anatomical organization of ANS.. 2. Discuss the synthesis, storage, release,. actions and degradation of . adrenergic . 3. Explain . adrenergic. transmission. 4. Discuss . Structure activity relationship (SAR)of sympathomimetic amines, Adrenergic antagonist and Neurone blockers Dr. ISHOLA I.O. PHARMACOLOGY, THERAPEUTICS AND TOXICOLOGY CMUL INTRO Phenylethylamine can viewed as parent compound, NA, AD, DA, ISOP Adrenalin, Noradrenalin. Sympathomimetics (direct & indirect). Sympatholytics. Adrenergic Receptors. Removal of Norepinephrine. Diffuse out of the synaptic cleft. Metabolized by COMT. Reuptake into the neuron. Adrenergic . Agents. Assist . Prof . Karima F. Ali. AL-Mustansiriyah university. College of pharmacy. Adrenergic drugs. . exert their principal pharmacological . and therapeutic . effects by either enhancing or reducing . Calcium Channel Blocker. WASU TACHAWATTANAKUL, M.D.. Objective. Pharmacologic properties of beta-adrenergic antagonist & calcium channel blocker. Clinical manifestation. Management & Antidote. sami. Cardiac Output (CO). CO =HR X stroke volume (SV). SV: is the amount of blood ejected from the ventricles with each beat – average is . approx. 70mls. SV is affected by . preload. , . contractility. . Dr. . Zahraa. M. . Ayad. Al-. mustaqbal. . University College. Department of . Nursing . 2. nd. Class. . Pharmacology /2. nd. semester. Adrenergic drugs (Sympathomimetic). Adrenergic drugs stimulate adrenergic receptors, thereby activating the sympathetic nervous system and inducing symptoms characteristic of the fight-or-flight response (sympathetic stimulation).. Objectives. Discuss the pharmacology of . catecholamines. Classify & describe adrenergic α-agonists including actions, therapeutic uses & adverse. reactions.. Classify & describe adrenergic β-agonists including actions, therapeutic uses & adverse. . Symaptholytics. Sensitivity of receptors. Two Families:. Alpha and Beta. Based on affinity to adrenergic agonists. Alpha affinity:. epinephrine. ≥norepinephrine. >> . isoproteranol. Beta affinity:. .. Adrenomimetics. - it is drugs that imitate the action of . noradrenaline. (NA) in the adrenergic synapses and cause the sympathetic effects on internal organs.. Thus, the main "target" action agonists is adrenergic synapse, which has certain structural and functional features..