PPT-PROF. A. K. SAKSENA ADRENERGIC RECEPTORS AND DRUGS

ADRENERGIC RECEPTORS α 1 α 2 Postsynaptic Presyn periphery Sm M of peripheral BV NT release . GraphG prof 1 prof 2 prof 3 prof 4 phd 5 stud 6 stud 7 adv adv adv adv adv sup sup GraphI 1 prof 2,3 prof 4 prof 5 phd 6,7 stud adv adv adv sup 1Fortheformaldevelopmentinthispaper,itwillbeconve-nientt GraphG prof 1 prof 2 prof 3 prof 4 phd 5 stud 6 stud 7 adv adv adv adv adv sup sup GraphI 1 prof 2,3 prof 4 prof 5 phd 6,7 stud adv adv adv sup 1Fortheformaldevelopmentinthispaper,itwillbeconve-nientt SYSTEM. . . TWO MAJOR DIVISIONS. PARASYMPATHETIC. -ganglia close to organ innervated. -. preganglionic. fibers are . myelinated. and long. -postganglionic fibers short and . unmyelinated. SYMPATHETIC. β-adrenergic antagonists are commonly used to treat hypertension, angina, tremor, migraine, and panic attacks.. ACTION. β-adrenergic antagonists competitively antagonize the effects . of . catecholamines. α. ADRENOCEPTOR ANTAGONISTS. Phenoxybenzamine. ,. Phentolamine. , . Tolazoline. , Ergotamine. , DHE, . Ergotoxine. Yohimbine. (. α. 2. ). Non-selective older drugs; Block both . α. 1. & . α. Def: The ANS consists of all visceral motor neurons innervating smooth muscle, cardiac muscle and glands.. Divide Autonomic Pharmacology into Four Categories:. 1. Drugs that increase the sympathetic nervous system response . Structure activity relationship (SAR)of sympathomimetic amines, Adrenergic antagonist and Neurone blockers Dr. ISHOLA I.O. PHARMACOLOGY, THERAPEUTICS AND TOXICOLOGY CMUL INTRO Phenylethylamine can viewed as parent compound, NA, AD, DA, ISOP Classify adrenergic antagonists . Describe actions, therapeutic uses & adverse effects of adrenergic antagonist.. b. Discuss the role of autonomic drugs in central nervous system disorders. c. Enlist drugs used in glaucoma. Nervous System. Part 2. . Thomas E. Tenner, Jr., Ph.D.. Dept. of Medical Education. Dept. Pharmacology & Neuroscience. tom.tenner@ttuhsc.edu. 743-7169. 1. Recommended Background Reading :.  . Chapters 7, 8, 9, and 10 . ACH is synthesized in the cholinergic neurons from choline and acetyl CoA then stored in synaptic vesicles then it will be release into synaptic gap to bind post synaptic receptors and lead to biological response.. . CLASSIFICATION. All are competitive antagonist at ‘M’. I. Natural Alkaloids:-. . . Atropine, . Hyoscine. II. Semisynthetic:-. . . Homatropine. , Ipratropium Br, . Tiotropium. Sympatholytics. ). Dr.. . Nirbhay. Kumar. Asstt. . Professor & Head. Deptt. . of Veterinary Pharmacology & Toxicology. Bihar Veterinary College, Bihar Animal Sciences University, Patna. These . sami. Cardiac Output (CO). CO =HR X stroke volume (SV). SV: is the amount of blood ejected from the ventricles with each beat – average is . approx. 70mls. SV is affected by . preload. , . contractility. . Dr. . Zahraa. M. . Ayad. Al-. mustaqbal. . University College. Department of . Nursing . 2. nd. Class. . Pharmacology /2. nd. semester. Adrenergic drugs (Sympathomimetic). Adrenergic drugs stimulate adrenergic receptors, thereby activating the sympathetic nervous system and inducing symptoms characteristic of the fight-or-flight response (sympathetic stimulation)..