PPT-Small Molecule Hormone Receptor (Nuclear Receptor)

VBC612 Unit1 PG 16102020 28102020 Nuclear receptors are intracellular proteins expressed in the nucleus of a cell that have a binding site for a particular steroid molecule Nuclear receptors . DR AMINA TARIQ. BIOCHEMISTRY. Survival of a multicellular organism depends on their ability to adapt to the constantly changing environment.. Intercellular communication mechanisms are necessary for this adaptation.. By. Dr. Ahmed . Hussain. A. . Mujamammi. . Clinical Chemistry Unit. Pathology Department. College of Medicine, KSU. OBJECTIVES. By the end of this lecture, students should be able to:. Acquire the knowledge for general consequence of hormone-receptor interaction . Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand. Receptor. Transducer. Effector. Second messenger. Target proteins/DNA. Ligands. Hormones vs Local mediators. Polar (insulin) vs nonpolar (steroidal hormone). Part A. Endocrine System: Overview. Acts with the nervous system to coordinate and integrate the activity of body cells. Influences metabolic activities by means of hormones transported in the blood . Endocrinology. Study of hormones. Specialized chemical messengers. Secreted by select cells. Action at distant sites via blood. Effects. Enzymatic reactions. Membrane transport. Gene expression. About this Chapter. CELL SURFACE RECEPTORS. Endocrine mediators. OUTLINE:. Sizes, origins and fate.. Occurance in blood: bound/unbound.. Listing of major examples.. Receptors and receptor binding.. Tour of a selected peptide hormone:. OBJECTIVES:. Explain why the endocrine system is so closely related to the nervous system.. Distinguish between an endocrine gland and an exocrine gland.. Define the term . hormone and explain its general characteristics.. Dr. Fatimah . Almahasneh. Department of Basic Medical Sciences. Yarmouk. University . Contents. Anterior pituitary gland. Growth hormone (GH). Prolactin. Posterior pituitary gland. Vasopressin. 2. Introduction. Learning Objectives. Learn the general structure and properties of hormones.. Know the differences between Hormones, Neurotransmitters & enzymes. 3. . Understand . the general properties of signaling molecules (ligands), cell-surface receptors, & intracellular signal transduction components.. by cells of the immune system are specifically called "cytokines". The following arethe classical endocrine organs of humans:1. Thyroid glandThyroid gland located in the frontal portion of the neck, u Table 1: Breast Cancer Cell Lines. . Changes in the total amount of hormone receptors will be determined by Western blotting. We expect that HCMV infection will reduce the expression of hormone receptors and decrease the cells’ responsiveness to extracellular stimuli.. Advanced Higher Biology. Definitions for this Key Area. What is an extracellular signalling molecule?. What is a target cell?. What is a receptor molecule?. What happens when a signal molecule binds to a receptor molecule?. Alzayadneh. , PhD. Integrative Physiology and Pharmacology. 1. Introduction to Physiology (0501110) Spring 2013. Subject. Lecture No.. Lecturer. Pages in the 11. th. edition. textbook. Pages in the 12. Overview of Endocrinology 2. Dr . Jeannie Todd. Lecture Outline. Hormone Receptors. Hormone mechanism of action at target tissues. Hormone feedback. Biological rhythms. Hormone Receptors 1. The capacity of cell to respond to particular hormone depends on presence of cellular receptors -specific for that hormone.