1 Leptospirosis is a kind of zoonotic infectious disease caused by pathogenic leptospires 2 rats and swine are cardinal source of infection 3 the disease often occurs in summer ID: 636488
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Slide1
LEPTOSPIROSISSlide2
DEFINITION
1. Leptospirosis is a kind of zoonotic
infectious disease caused by pathogenic leptospires;
2. rats and swine are cardinal source
of infection;
3. the disease often occurs in summer
and fall;
Slide3
DEFINITION
4. clinical features:
three symptoms,
three signs,
internal organ damage,
seguelae of eyes and nerve system
5. treatment: penicillin.
Slide4
ETIOLOGY
1.pathogen : pathogenic leptospira
2.features of leptospia:
helicoid with hook,
length 6~ 20 um,G
-
darkfield microscope;
in korthof’s media;
Slide5
ETIOLOGY
several months in water and
moist soil (PH7.0~7.5)
3.Classification:
23 serogroups and more then 200
serotypes in the world;
19 serogroup and 74 serotypes in china.
icterohemorrhagic group,
pomona groupSlide6
1.Source of infection: rat: apodemus agrarius,
rice field type;
pigs: flood or rain type;
patient
EPIDEMIOLOGYSlide7
EPIDEMIOLOGY
2.Routes of transmission:
(1) water borne (indirect contact
transmission):
by skin,mucosa,when skin is injured.
(2) direct contact transmission:
(3) food borne
3.Susceptibility of population:
Slide8
EPIDEMIOLOGY
4.Epidemiologic features:
(1)season: summer and fall;
(2) nosogenic age:
young and middle age,children
(3)occupation:
farmer,slaughter,
fisher,veterinarian.Slide9
EPIDEMIOLOGY
4.Epidemiologic features:
(4)epidemic type :
rice field type
flood type
rain typeSlide10
PATHOGENESIS
leptospira
skin,mucosa
Initial stage leptospiremia
toxic symptoms
(1~3days) three symptoms:
fever,myalgia,fatigue;
three signs:
conjunctival suffussion;
muscle tenderness;
enlargement of lymphonodes;
Slide11
PATHOGENESIS
severe toxic symptoms
lesion of organs:
influenza form
pneumorrhagic form
middle stage icterohemorrhagic form
(3~10d)
meningoencephalitis
renal failure form.
Slide12
PATHOGENESIS
immunopathological reaction
after fever;
sequelae of eyes;
reactive
meningitis;
cerebro arteritis
obliterans.
convalescent stageSlide13
PATHOLOGY
1. basic pathological change is
infective,toxic injured of systemic
capillaries;
2. severe:lung,liver,kidneys,brain.
exudation,hemorrhage,
edema or necrosis.
Slide14
CLINICAL MANIFESTATIONS
Incubation period: 2~28 days
usually 7~13days;
1. Influenza-typhoid type:5~10days
three symptoms:
fever,myalgia and fatigue.
three signs:
conjunctival suffusion,
Slide15
CLINICAL MANIFESTATIONS
three signs:
conjunctival suffusion,
tenderness of
gastrocnemius muscle;
enlargement and tenderness
of superficial lymphnodes.
Inguinal and axillary
lymphodes.
Slide16
CLINICAL MANIFESTATIONS
2. pneumorrhagia form:
1). three symptoms and three signs
2). pneumorrhagia symptoms(3~4d)
(1). mild pneumorrhagia type
cough,expectoration with blood.
a few moist rales.
X-ray of chest: scattering spotty and small fasciola shadow
dyspnea,
palpitaton,aspharyxia,rales.
Slide17
CLINICAL MANIFESTATIONS
2. pneumorrhagia form:
(2) diffuse pneumorrhagia type
short breathing, palpitation,
dysphoria,
massive hemoptysis, asphyxia,
cyanosis,
a lot of moist
rales.
X-ray: extensive fasciola shadow
. Slide18
CLINICAL MANIFESTATIONS
3.Icterohemorrhagic type
:(Weil
,
s disease)
1). three symptoms and three signs
2). jaundice, hemorrage, renal injury
(4~5d)
liver injury:
anorexia,vomiting, jaundice,
abnormal liver function.Slide19
CLINICAL MANIFESTATIONS
3.Icterohemorrhagic type
:(Weil
,
s disease)
hemorrhage: petechiae,ecchymoses,hemoptysis,hematemesis etc.
renal injury: proteinuria,
RBC, WBC, cast,
oliguria,azotemia,uremia.Slide20
CLINICAL MANIFESTATIONS
4.renal failure type:
oliguria, azoteinia, uremia.
5.meningoencephalitis type:
1). three symptoms and three signs
2). 3~4days later, meningitis, encephalitis.
headache,vomiting,meningeal irritation,
lethargy,coma,paralysis or convulsion.Slide21
CLINICAL MANIFESTATIONS
CSF is abnormal.
pressure increase
pleocytosis<500
×
10
6
/L
protein is normal or elevated slightly.
glucose and chloride is normal.
leptospira isolation: positive.Slide22
SEQUELAE
1. after fever :
1~5days after defervascence
2. sequelae of eyes:
1week~1month
iridocycyclitis, choroiditis , uveitis
3.reactive meningitis
4.cerebroarteritis obliterans:
2w~2m
hemiplegia aphasia
CLINICAL MANIFESTATIONSSlide23
LABORATORY FINDINGS:
1. routine examination:
1). blood routine examination:
WBC is increased slightly;
2).urine routine examination:
protein (2/3)
2. serological examination:
1).microscopic agglutination test (MAT)
detect antibody >1:400
Slide24
LABORATORY FINDINGS:
2). ELISA: serum and CSF IgM antibody
3. pathogenic test
1).blood culture:
2).PCR: DNA
Slide25
DIAGNOSIS
1.epidemiologic data:
1).epidemic area;
2).epidemic season;
3).a history of contact with contaminated
water;
2.clinical manifestations:
3.Lab findings:Slide26
DIFFERENTIAL DIAGNOSIS
1.Influenza; Typhoid fever,
2.Lobar pneumonia;
3.Viral hepatitis;
4.Viral meningitis;
5.Epidemic hemorrhagic fever;Slide27
TREATMENT
1.Pathogenic therapy
1). first choice: penicillin
40
万 u q6h or q8h im 7days
note: Herxheimer reaction
first time - small amount 5
万 u
im
2). Gentamycin
8
万 u
q8h imSlide28
TREATMENT
2.Symptomatic therapy
1).
Herxheimer reaction
physical cooling
,
sedative,
hydrocortisone.
2). pneumorrhagia type
sedative, hydrocortisone, cardiotonics
3.treatment of sequleaSlide29
PREVENTION
1.control of pigs:
1). stable breeding
2).immunized by vaccine
2.killing of rats,
3.cutting route of transmission,
4.vaccination:
multivalent vaccine