PPT-The Major Histocompatibility Complex (MHC)

Ali Al Khader MD Faculty of Medicine AlBalqa Applied University Email alialkhaderbauedujo With some language corrections o n Serotonin file An introduction to adaptive immune system before we discuss MHCB cells. Cell and its Role in Adaptive Immunity and Cancer Immunotherapy. Amna. Muhammad. Ph. D scholar. Biochemistry. 1. Contents. Introduction. Dentritic cell and control of immunity. Immunity. Antigen Presentation to T cells. Xiaoying Chen, . Timothy Hickling. , Paolo Vicini. PDM-NBE, Pfizer, USA. New technologies for immunogenicity assays/prediction. European Immunogenicity Platform February 23-25, 2015 . Complexity of Immunogenicity. . B/T cell . development. . . B. . T. Adaptive . immunity . . B/T . cells. . Innate . immunity. BCR/TCR: . epitope. recognition. Gene rearrangement of . AgR. Pattern . recognition. BCR/TCR:. Basic Principles of . T Cell Development. Each cell randomly rearranges a specific TCR.. The presence of the pMHC epitope, stage of development and “costimulation” determine the cell’s fate.. Functional Immunity & Tolerance result from the sum of a large population of many sequential pMHC epitope specific cellular responses.. Evolutionary Mechanisms. Genetic Drift . Migration. Mutations. Natural Selection. Non-adaptive. Adaptive. Natural. . . Selection. (1) Sexual Selection. (2) Constraints on Natural Selection. Pleiotropy. Polyandry. Female receptive and/or actively mating with multiple males. Mate guarding may prevent in some cases, but clearly not all. Why is polyandry adaptive for females?. They invest much more in the egg and the parental care. Jorge Duitama. 1,2. , Thomas . Huebsch. 1. , Gayle McEwen. 1. , . Sabrina Schulz. 1. , . Eun. -Kyung . Suk. 1. , Margret R. . Hoehe. 1. 1. . Max Planck Institute for Molecular Genetics, Berlin, Germany. Genetics . in . Salmon Restoration. : . Insights . from . Functional Genes. Melissa . Evans, Sam . Shry. , Nick . Sard. , Dave Jacobson, . & . Kathleen . O’Malley. Fisheries Genetics Lab, Oregon State University. Salmon Restoration. : . Insights . from . Functional Genes. Melissa . Evans, Sam . Shry. , Nick . Sard. , Dave Jacobson, . & . Kathleen . O’Malley. Fisheries Genetics Lab, Oregon State University. La gamme de thé MORPHEE vise toute générations recherchant le sommeil paisible tant désiré et non procuré par tout types de médicaments. Essentiellement composé de feuille de morphine, ce thé vous assurera d’un rétablissement digne d’un voyage sur . Hepatic Granulomas. Marusia Popovech, PhD, MPH. Senior Toxicologist, ExxonMobil Biomedical Sciences, Inc.. Member, CONCAWE STF-33 October 18, 2017. Introduction. F344 Hepatic Granuloma. Strain-Dependent Differences . Complex, MHC 1 Ning Pan Department of Pathogen biology and Immunology Medical School , Southeast University 2 • George Snell ( 1903 - 1996 ) discovered the first components of the MHC through their The MHC complex resides in the short arm of chromosome 6 and overall size of the MHC is approximately 3.5 million base pairs. The complete three-dimensional structure for both class I and class II MHC MHC class I and class II proteins. A: The class I molecule consists of a MW 44,000 polymorphic transmembrane polypeptide (α chain) . noncovalently. associated with a MW 12,000 . nonpolymorphic. polypeptide (β2-microglobulin) that is not anchored in the membrane. The three extracellular domains of the α chain are designated α1, α2, and α3. The binding site for antigenic peptides is formed by the cleft between the α1 and α2 domains; CD8 contacts a portion of the α3 domain. B: The class II molecule consists of a MW 34,000 α chain .