PDF-MHC MAJOR HISTOCOMPATIBILITY COMPLEX MHC complex is group of genes o

The MHC complex resides in the short arm of chromosome 6 and overall size of the MHC is approximately 35 million base pairs The complete threedimensional structure for both class I and class II MHC. Evolutionary Mechanisms. Genetic Drift . Migration. Mutations. Natural Selection. Non-adaptive. Adaptive. Natural. . . Selection. (1) Sexual Selection. (2) Constraints on Natural Selection. Pleiotropy. Xiaoying Chen, . Timothy Hickling. , Paolo Vicini. PDM-NBE, Pfizer, USA. New technologies for immunogenicity assays/prediction. European Immunogenicity Platform February 23-25, 2015 . Complexity of Immunogenicity. . B/T cell . development. . . B. . T. Adaptive . immunity . . B/T . cells. . Innate . immunity. BCR/TCR: . epitope. recognition. Gene rearrangement of . AgR. Pattern . recognition. BCR/TCR:. Dr Nisar Anwar. FRCP(Edin),Accredited Renal Physician (UK). Professor & Head : Department Of Nephrology. KTH, Peshawar. TERMINOLOGY OF TRANSPLANTATION. Auto graft . (e.g. skin grafts for burns, etc.). Chapter 17. Transplantation. is a widely used . treatment. for . replacement. of nonfunctioning organs and tissues with healthy organs or tissues. Technically, transplantation is the process of taking . Basic Principles of . T Cell Development. Each cell randomly rearranges a specific TCR.. The presence of the pMHC epitope, stage of development and “costimulation” determine the cell’s fate.. Functional Immunity & Tolerance result from the sum of a large population of many sequential pMHC epitope specific cellular responses.. Evolutionary Mechanisms. Genetic Drift . Migration. Mutations. Natural Selection. Non-adaptive. Adaptive. Natural. . . Selection. (1) Sexual Selection. (2) Constraints on Natural Selection. Pleiotropy. Polyandry. Female receptive and/or actively mating with multiple males. Mate guarding may prevent in some cases, but clearly not all. Why is polyandry adaptive for females?. They invest much more in the egg and the parental care. Chapter 17. Transplantation. is a widely used . treatment. for . replacement. of nonfunctioning organs and tissues with healthy organs or tissues. Technically, transplantation is the process of taking . SUMMARY. 1| . Introduction. 2|. MHC class II structure. 3|. Labile regions. 4| . Non-Classical HLA. 5| . The peptide binding site. 6. |. CD4 – HLA interaction. 7. |. Conclusions. INTRODUCTION. MHC-I. Hepatic Granulomas. Marusia Popovech, PhD, MPH. Senior Toxicologist, ExxonMobil Biomedical Sciences, Inc.. Member, CONCAWE STF-33 October 18, 2017. Introduction. F344 Hepatic Granuloma. Strain-Dependent Differences . Shawk. Transplantation. After reading this chapter, you should be able to:. describe your current understanding to transplantation. discuss some of the characteristics of the most commonly transplanted tissues. Complex, MHC 1 Ning Pan Department of Pathogen biology and Immunology Medical School , Southeast University 2 • George Snell ( 1903 - 1996 ) discovered the first components of the MHC through their MHC class I and class II proteins. A: The class I molecule consists of a MW 44,000 polymorphic transmembrane polypeptide (α chain) . noncovalently. associated with a MW 12,000 . nonpolymorphic. polypeptide (β2-microglobulin) that is not anchored in the membrane. The three extracellular domains of the α chain are designated α1, α2, and α3. The binding site for antigenic peptides is formed by the cleft between the α1 and α2 domains; CD8 contacts a portion of the α3 domain. B: The class II molecule consists of a MW 34,000 α chain .