PPT-An investigation into the stability and solubility of amo

Shrawan Baghel WIT Project Outline An investigation into the crystallization tendencykinetics of amorphous active pharmaceutical ingredients A case study with dipyridamole and cinnarizine 1 Fragility. Before discussing the stability test let us rst introduce the following notions of stabilit y for a linear time invariant LTI system 1 BIBO stability or zero state stbaility 2 Internal stability or zero input stability Since we have not introduced t Positive deviation of the enthalpy of mixing and consequently limited solid solubility may be predicted from known atomic properties.. Hume-. Rothery. - empirical rules to predict solid solubility. For solid solubility exist b/t two elements, the following settlements are always true:. Do Now: label as soluble and insoluble. 1. CH. 4. 2. . AgCl. 3. C. 12. H. 22. O. 11. 4. NaNO. 3. 5. KOH. Review: Next 3 slides. Water is often used as a solvent. Soluble = dissolves in water = . aq. Insoluble = doesn’t dissolve in water. Summer 2012. Separatory. Funnel. Separation of immiscible liquids. Extraction. To . pull out. a compound from one layer into another. A compound partitions more toward where it is more soluble (equilibrium). Recall, solubility is the amount of solute that dissolves in a given volume of solvent at a certain temperature. .. Solubility is determined by the intermolecular attractions between solvent and solute particles. Teresa Fuller. GSK. Stability Indicating Assays for Dose Formulation Stability Testing. Stability Studies for Dose Formulations. What the white paper says. What is a stability indicating assay?. So do we need a stability-indicating assay?. Mixtures. Solutions are a type of mixture, so to understand solutions, first we have to know what a mixture is…. A . mixture. is a combination of two or more substances. Each substance keeps it’s own properties, even though it is mixed with another substance. They . Who’s who in the sandbox. (updated for 2016). The Ministry of Environment and Climate Change (MOECC). The Association of Municipalities of Ontario (AMO). The City of Toronto (not a member of AMO). Regional Public Works Commissioners of Ontario (RPWCO). Question. How does changing the temperature of the solvent effect the solubility of the solute in water?. Background questions. What effects do solutes have on a solvent’s freezing point and boiling points? . La gamme de thé MORPHEE vise toute générations recherchant le sommeil paisible tant désiré et non procuré par tout types de médicaments. Essentiellement composé de feuille de morphine, ce thé vous assurera d’un rétablissement digne d’un voyage sur . CANKAR . VRHNIKA. Noi. . siamo. . studenti. . della. . nona. . classe. . della. . scuola. . media. Ivan Cankar . di. Vrhnika in . Slovenia. . Tutti . abbiamo. 15 . anni. . . Studiamo. l'.                       !  "  !  # $ %" # $&'())*(+, -'(.(./0.(+1..1. 23'- 14 53 67.3'7 8(,8 . David . Litzinger. , PhD. Director, Pharmaceutical Sciences. Amylin Pharmaceuticals, Inc.. PEGS Conference. May 20, 2010. Boston, MA. Small . Molecules. <. 500 Da. Peptides. 1-6 kDa. Proteins. 15-150 kDa. cont. ). High/Positive phase: . the jet is shifted towards higher latitude, the polar vortex is intensified, and cold air is walled off in the polar vortex. . Low/Negative phase. , the vortex is weaker, the jet is shifted southward, and cold air outbreaks are more common.