PPT-An investigation into the stability and solubility of amo

Shrawan Baghel WIT Project Outline An investigation into the crystallization tendencykinetics of amorphous active pharmaceutical ingredients A case study with dipyridamole and cinnarizine 1 Fragility. A Physical Property. A . Definition of solubility:. . A measure of how much solute can dissolve in a solvent at a given temperature. .. What is a . solvent. ?. A substance that dissolves another substance.. Summer 2012. Separatory. Funnel. Separation of immiscible liquids. Extraction. To . pull out. a compound from one layer into another. A compound partitions more toward where it is more soluble (equilibrium). Chapter 18. Is . AgCl. soluble or insoluble?. Dissolution Reactions and . K. sp. Expressions. AgCl. (s). Mg(OH). 2. (s). Ca. 3. (PO. 4. ). 2. (s). Standard Reaction Types:. Determining . K. sp. Experimentally. Mineral Surfaces & Reactions. Lecture 22. Constructing stability . diagrams. This diagram shows the stability of ferrous iron minerals as a function of pH and sulfide for fixed total Fe and CO. 2. Introduction. Preformulation study is the foundation of developing robust formulation.. It can be defined as a phase of research & development process for an investigation of physical and chemical properties of new drug substance alone or in combination with other . Gout primarily affects adult men over the age of 40. . Attacks of gout may occur when the concentration of uric acid in blood plasma exceeds its solubility of 7 mg. /. 100 mL of plasma at 37 . °. Chapter 7.6. Solubility . Equilibria of . Ionic Compounds. Solubility . is . the quantity of solute that dissolves in a given quantity of solvent at a particular temperature. A . solubility equilibrium . Question. How does changing the temperature of the solvent effect the solubility of the solute in water?. Background questions. What effects do solutes have on a solvent’s freezing point and boiling points? . Part 2. Solubility Analysis. Preformulation solubility . studies . focus . on:. Drug-solvent . systems that could occur . during the . delivery of a drug candidate. . E.g.: a drug . for oral . administration should . Nutrition & Health. Curcumin – a multifunctional compound from natural sources and current state of its research. Zorka . D. . Stanic. Faculty of Science. University of Kragujevac. February 20-21, 2017 Berlin, Germany. David . Litzinger. , PhD. Director, Pharmaceutical Sciences. Amylin Pharmaceuticals, Inc.. PEGS Conference. May 20, 2010. Boston, MA. Small . Molecules. <. 500 Da. Peptides. 1-6 kDa. Proteins. 15-150 kDa. Many solids and gases dissolve in water. As you increase the temperature, you can dissolve more solid. Does this work the same with gas?. NO – as you increase temp, gas molecules KE !. Where can you go to find if something is soluble or insoluble in water?. Rama . Karadsheh. . 1. , and Megan . Meuser. . 1. , Simon . Cocklin. . 1*. . 1. Department of Biochemistry, Drexel University, 245 North 25. th. Street, Philadelphia, Pennsylvania, USA. *. Corresponding author: sc349@drexel.edu. Complex Ion Formation. Multiple Equilibria. Factors Affecting Solubility. Solubility Equilibrium. E. quilibrium . between . precipitates or solid compounds and their ionic species in aqueous solutions;.