From ESH 2016 POS 3C Luiz Aparecido Bortolotto MD PhD Heart Institute University of São Paulo Brazil Overview Observational study of global and domainspecific cognitive function and the correlation between cognitive performance and arterial properties in Stage 1 to 3 hyperten ID: 525386
Download Presentation The PPT/PDF document "Arterial Alterations Contributed to Redu..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Arterial Alterations Contributed to Reduced Cognitive Function in Hypertension
From ESH 2016 | POS 3C:
Luiz
Aparecido
Bortolotto
, MD, PhD
Heart Institute, University of São Paulo, BrazilSlide2
Overview
Observational study of global and domain-specific cognitive function and the correlation between cognitive performance and arterial properties in Stage 1 to 3 hypertension
vs
normotension
Cognitive impairment was more frequent in adults with than without arterial hypertension
Arterial alterations contributed to reduced domain-specific cognitive functionSlide3
Study Population
162 adults; of 120 adults with hypertension, 40% had Stage 2, 30% Stage 1, 30% Stage 3
Exclusion criteria were current smoking, diabetes, arrhythmia, ventricular dysfunction, and neurodegenerative disease
Hypertension group significantly older, fewer were white, shorter duration of education, higher levels of systolic and diastolic blood pressureSlide4
Baseline Characteristics in Study Patients
Variable
Study groups
p
value
Control
(42)HTN (120)Age, mean (SD)44.74(11.42)51.07(11.05)0.003Sex, Male No (%)29 (69)55 (45.8)0.636Race, white, No (%)37(88.1)83 (69.2)<0.001BMI (kg/m2)26.98(3.96)29.74(4.63)0.238Education, mean (SD) y14.88(4.06)9.99(4.43)<0.001SBP, mean (SD) mmHg121.90(7.15)141,45(23,48)<0.001DBP, mean (SD) mmHg76.12(6.95)87,28(13,42)0.003
BMI, body mass index; DBP, diastolic blood pressure; SBP, systolic blood pressure.Slide5
Results
Some arterial parameters significantly higher in hypertension
vs
control, adjusted for age and difference in blood pressure
Carotid artery diameter, mean pulse wave velocity, mean augmentation index, mean central SBP, mean central DBP
Scores for global cognitive status significantly lower in hypertension
vs
control, adjusted for age and duration of educationMini Mental Status Examination 26.97 vs 28.6 and Montreal Cognitive Assessment 23.86 vs 26.7 (p<0.01 for both)Each of 5 cognitive function domains significantly lower in hypertension vs control, adjusted for age and duration of educationSlide6
Cognitive Function in Five Domains by Study Group
Variable
Study groups
p
value
Control
(42)HTN (125)Language86,18±668,03±5<0.01Memory62.91±456.21±4<0.01Executive Functions (time, s)192±26332±54<0.05Spatial and visual perception38.58±334.83±4<0.05Concentration 78.05±756.23±7<0.01HTN, hypertension.Slide7
Correlation of Arterial Properties and Cognitive Outcomes
Significant inverse relation found between augmentation index and global cognitive tests, adjusted for age and duration of education
Augmentation index correlated with executive function, language, visual spatial perception, concentration
Pulse wave velocity correlated with executive function, memory, concentration
Carotid diameter correlated with executive function, visual spatial perception
Causal relation between arterial alterations and cognitive performance could not be established in this study Slide8
Arterial Alterations Contributed to Reduced Cognitive Function in Hypertension
From ESH 2016 | POS 3C:
Luiz
Aparecido
Bortolotto
, MD, PhDHeart Institute, University of São Paulo, Brazil