PPT-ATTR Amyloidosis: A Progressive Multisystemic Disease

Adams D et al J Neurol 202126821092122 Rozenbaum MH et al Cardiol Ther 202110141159 Lousada I et al Orphan J Rare Dis 20151022 Multiple misdiagnoses have been reported in up to . . . Multiple. . myeloma. . . Amyloidosis. .. Part 2. Dr. Gábor . Mikala. Waldenström. . Macroglobulinemia. Uncontrolled proliferation of . lymphoplasmacytes. producing . IgM. Median age . 63 years. A Spotlight on New Disease-Modifying . Therapies Across the Clinical Spectrum. Supported by an educational grant from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC.. About These Slides. of Amyloidosis. Case: PCP Presentation. Clinical Presentations of Amyloidosis . Hereditary Transthyretin Amyloidosis . ATTR Prevalence. Delay in Diagnosis. Clinical Burden Associated With Lack of Recognition and Diagnosis of ATTR Amyloidosis. Introduction. Clinical Burden Associated With Lack of Recognition and Diagnosis of ATTR Amyloidosis. Patients Who Present With Peripheral Neuropathy. Clinical Examination and Diagnostic Tools to Confirm Diagnosis of hATTR Amyloidosis . . Razick. overview. Patient presentation. CC: . “I feel good”. AF is an 88-year-old female returning to the Advanced Heart Failure Clinic for a follow up appointment where she is monitored closely for her heart failure associated with a PYP scan for possible amyloidosis. . ASSTT. PROFESSOR,. DEPTT. OF PATHOLOGY, BVC, PATNA. What is amyloid. Amyloid . (G. . Amylon. . - STARCH) means starch-like. Amyloid is a pathologic glycoprotein deposited in the extracellular spaces and forms fibrils on polymerization.. . myeloma. . . Amyloidosis. .. Part 2. Dr. Gábor . Mikala. Waldenström. . Macroglobulinemia. Uncontrolled proliferation of . lymphoplasmacytes. producing . IgM. Median age . 63 years. Presents with weakness, fatigue, . . . Manoj. . Radhakrishnan. Dept. of Pathology , SKHMC. nature of . amyloid. amyloid. is a . protienaceous. substance deposited between cells in various tissues and organs in a variety of clinical settings. Ibraheem. Amyloidosis . is a disorder characterized by the extracellular deposits of . misfolded. . proteins that aggregate to form insoluble fibrils (beta-pleated sheet) conformation.. Generally . Presented by. MST Services. Revised – February 2016. Multisystemic Therapy (MST) Overview. 1. What is “MST”? . Community-based, family-driven treatment for antisocial/delinquent behavior in youth. 1. ATTR-CM occurs when transthyretin amyloid fibrils aggregate and deposit in the myocardium, resulting in an infiltrative, restrictive cardiomyopathy characterized by both right and left heart failure, initially with preserved ejection fraction. A Guide to Authored by Teresa Coelho, Bo - Goran Ericzon, Rodney Falk, Donna Grogan, Shu - ichi Ikeda, Mathew Maurer, Violaine Plante - Bordeneuve, Ole Suhr, Pedro Trigo 2016 Edition Edited by Merr Anita D’Souza, MD, MS. Froedtert. & MCW Cancer Center. Milwaukee, WI. Objectives. Types of amyloidosis. How does amyloidosis form?. Why does myeloma sometimes make amyloid?. Treatment of amyloidosis. Amyloid is deposited predominantly in the extracellular space in various tissue and organs. With progressive accumulation, it encroaches on and produces pressure atrophy of adjacent cells. AMYLOIDOSIS.