PPT-Ergot

Ergot fungus Claviceps purpurea Ergot Life Cycle Ergot Pharmacology Ergotamine Ergosine Lysergic Acid Diethylamide LSD Serotonin a neurotransmitter. The most obvious external symptom of infection is the abundant exudation from infected flowers of an ambercol ored sticky fluid or honeydew which often drips onto the leaves and soil Spores of the fungus are contained within the honeydew and when th Drugs for Headache. Headache. Common symptom. Triggered by a variety of stimuli. Stress, fatigue, acute illness, sensitivity to alcohol. Mild episodes . Relieved by over-the-counter drugs (OTCs) (e.g., aspirin, acetaminophen). alkaloids. Class . Precursors. . Examples. . _____________. . Piperidine. alkaloids L-lysine (C. 5. N) . Piperine. Pyrrolidine. /. tropane. . alkaloids. . L-. ornithine. . (C. 4. N) . Cocaine. Precursor is formed by combining two C. 6. C. 2. units, both originating from tyrosine. Focus: . pieces/precursors. key assembly steps. structure-activity. physiological interactions. First . methylation. alkaloids. Vinca. , . Rauwolfia. , Ergot, . Nux. . vomica. Indole. Alkaloids. Ergot . Alkaloids. Occurrence:. . Ergot. is the dried . sclerotium. . of a . fungus. ,. . Claviceps. . purpurea. Jack . Biko. Galactorrhea. Non-. pueperal. secretion of milk . Confirmed by visualizing fat droplets in secretions using low power microscopy.. Galactorrhea. Isolated . galactorrhea. , with . normal menses and normal serum . John Benner. Matt Booher. From the Extension publication: . “Making the Most of Fescue in Virginia”. Endophyte. Infection Levels in the Shenandoah Valley. 2013: Tested . 26 pastures in Rockingham, Augusta, & . Andrew Nguyen and Anthony Haynes. Sorcery and Herbalism: the basis of Witchcraft. Prior to 1350 and the height of the Roman Catholic church, witchcraft was simply sorcery, and it was an accepted part of life having been ingrained in culture for centuries. . Begay. -Bruno. Michael Burnett. Hannah Martinez. Michael McKitrick. Why we chose ergotamine…. When we started discussing potential toxins, ergotamine was one of the first suggested. Exploring ergotamine was appealing because it has a long association with human society that continues to the present day. Ergotamine has caused disease epidemics, and yet it has also been used in folk remedies. Its related compounds continue to be used in the modern era industrially, clinically, and recreationally.. Alkaloids. Definition:-. Alkaloids are natural compounds display an . expceptionally. wide array of biological activities and have a wide distribution , being present in plants, fungi, bacteria, insects, marine, animal and man.. INDOLE ALKALODS. a class of . alkaloid.  containing . a structural moiety of . indole. ; many . indole. alkaloids also include.  . isoprene.  groups and are thus called . terpene. . indole. . or . Predictable, frequent early morning (2AM to 5AM) headaches Low pain threshold upon physical or cognitive exertion Headaches accompanied by asthenia, nausea and other GI symptoms,restlessness, anxiety, A source of some controversy, certain opioids are recommended in some guidelines, e.g. by the American Headache Society. 4. , but advised against in others, e.g. by Canadian Headache Society and European Headache Federation. Dr. Nadheerah F Neamah. Progressive . loss of selected neurons. in discrete brain areas,. resulting in characteristic disorder of movement, cognition, . or both . Include:. • Alzheimer disease: dementia and disordered .