PPT-Serotonin & the Ergot Alkaloids

Assist Professor Dr Haitham M Alwali PhD Pharmacology Al Nahrain College of Pharmacy 3152018 1 Serotoninamp the Ergot Alkaloids S erotonin 5hydroxytryptamine 5HT is . Ergot is a fungus that infests grasses and if eaten in sufficient quanti ties is poisonous to humans and livestock due to the produc tion of a mycotoxin Ergot will only be seen in grasses that has DOUHDG5734757523KHDGHG RXW575245736157347573477KHUHI Drugs for Headache. Headache. Common symptom. Triggered by a variety of stimuli. Stress, fatigue, acute illness, sensitivity to alcohol. Mild episodes . Relieved by over-the-counter drugs (OTCs) (e.g., aspirin, acetaminophen). alkaloids. Class . Precursors. . Examples. . _____________. . Piperidine. alkaloids L-lysine (C. 5. N) . Piperine. Pyrrolidine. /. tropane. . alkaloids. . L-. ornithine. . (C. 4. N) . Cocaine. Precursor is formed by combining two C. 6. C. 2. units, both originating from tyrosine. Focus: . pieces/precursors. key assembly steps. structure-activity. physiological interactions. First . methylation. the . adverse physiology in livestock that are exposed to . ergopeptines. Glen Aiken. USDA-ARS Forage-Animal Production Research Unit. Lexington, KY. United States Department of Agriculture. Agricultural Research Service. alkaloids. Vinca. , . Rauwolfia. , Ergot, . Nux. . vomica. Indole. Alkaloids. Ergot . Alkaloids. Occurrence:. . Ergot. is the dried . sclerotium. . of a . fungus. ,. . Claviceps. . purpurea. Andrew Nguyen and Anthony Haynes. Sorcery and Herbalism: the basis of Witchcraft. Prior to 1350 and the height of the Roman Catholic church, witchcraft was simply sorcery, and it was an accepted part of life having been ingrained in culture for centuries. . HPTLC–FLD/MS. Claudia Oellig. Institute . of. Food Chemistry, University . of. . Hohenheim. Germany. HPTLC-FLD. ERGOTS. Ergots. . Produced by parasitic fungi, e.g. . Claviceps. . purpurea. . By Johannes Johnston. Literature 2111. Background. The hunting of witches started in the middle of the 14. th. . to the late 18. th. Century. Estimate of 40,000 to millions of people were burned, hanged, or tortured for witchcraft.. Ergotoxins. Dr.. Rashmi . Rekha. Kumari. Asstt. . . Prof.. cum Jr. Scientist. Deptt. . Of . Vety. . Pharmacology and Toxicology. B.V.C, . BASU,Patna. VPT-609 (. 2+0. ). Toxicology of Plants and Toxins. Alkaloids. Definition:-. Alkaloids are natural compounds display an . expceptionally. wide array of biological activities and have a wide distribution , being present in plants, fungi, bacteria, insects, marine, animal and man.. INDOLE ALKALODS. a class of . alkaloid.  containing . a structural moiety of . indole. ; many . indole. alkaloids also include.  . isoprene.  groups and are thus called . terpene. . indole. . or . Alkaloids and Heterocyclic Compounds.. . Alkaloids. Alkaloids are a class of basic and cyclic organic compounds, naturally occurring consist of carbon, hydrogen mainly, and nitrogen and usually oxygen. . A source of some controversy, certain opioids are recommended in some guidelines, e.g. by the American Headache Society. 4. , but advised against in others, e.g. by Canadian Headache Society and European Headache Federation.