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Nanoparticles   Risk   Analysis Nanoparticles   Risk   Analysis

Nanoparticles Risk Analysis - PowerPoint Presentation

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Nanoparticles Risk Analysis - PPT Presentation

ISOLDE NhâtTân VUONG 1 Swiss Federal Institute of Technology Lausanne Master student Chemical amp Biochemical Engineering Intership at CERN For 5 months ISOLDE ID: 802944

method analysis risk hazard analysis method hazard risk oxide yttrium band isolde anses measures level nps control size nanoparticles

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Presentation Transcript

Slide1

Nanoparticles Risk Analysis

ISOLDENhât-Tân VUONG

1

Slide2

Swiss Federal Institute of Technology, Lausanne

Master

student, Chemical & Biochemical EngineeringIntership at CERNFor 5 monthsISOLDEEN-STI-RBS2

Slide3

IntroductionNano-objects

At least 1dimension size ≤ 100 nm

Why are NanoParticles (NPs) so important ?New physical and chemical propertiesHigh Surface Area3

Slide4

IntroductionApplications of nanotechnology

SuncreamPaintElectronics

Drug deliveryMaterial reinforcementCatalystsBiosensorsNanorobots4

Slide5

ISOLDE : irradiation of

targets

in order to create a secondary ion beam Study the nuclei, medical applications, …Nano at ISOLDE : Nanoparticles are used (Y2O3) Nanoparticles are produced (CaO) Nano activity at ISOLDE

5

Slide6

NanopowderWeight 1gPress to pellets

Pellets in a container Nano

activity at ISOLDE in a target6

Slide7

DNA damagesRespiratory problems

Blood coagulationCardiovascular problems

Genotoxicity and cytotoxicityCellular deathNanoHazards7

Slide8

Aim : Evaluate the risk and implement

appropriate prevention/protection measures

Simple model :Risk = Hazard x ExposureQuestion : How to quantify Hazard and Exposure ?Risk Analysis8

Slide9

ContextNanotechnology = Emerging

technologyLack of information on NPs

Human toxicological effects are unknownSize make NPs difficult to detect/measure There are too many uncertainties It is difficult to quantify Hazard and Exposure Appropriate risk analysis method is requiredRisk Analysis9

Slide10

Management of nanomaterials

safety

EPFL - Ecole Polytechnique Fédérale de Lausanne, Switzerland 2010Laboratory, Nano1 → Nano3«Control Banding» methodsSamuel Y. Paik and al. - Lawrence Livermore National Laboratory, CA, USA 2008ANSES - Agence Nationale de Sécurité Sanitaire, France 2011Control level, CL1 → CL5Risk Analysis - Methods10

Slide11

Risk AnalysisConcept of «control banding

»11

Control Level = Hazard Band x Emission Potential BandControl level matrix

Slide12

Hazard

Band assessment

HB1→ HB5Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDE12

Slide13

Hazard

BandYttrium

Oxide Nanoparticles – which size ?Supplier : particles size 25-50 nmScanning Electron Microscope (SEM)13Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDE

Slide14

Hazard Band

Other analysis

Particle size distribution (PSD)Average particle size approx. 10 μmSpecific Surface Area (SSA, m2/g), BET methodAverage diameter approx. 68 nm14Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDE

Slide15

Hazard

Bandassessment

15Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDE

Slide16

Hazard

Band

AssessmentBulk Yttrium oxide-> HB316Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDEBulk Material Hazard Band ?(Original Band)

Slide17

Hazard

Band assessment

Resulting Hazard BandHB517Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDEHB3

HB4HB5

Slide18

Emission

Potential

Band assessmentResulting Exposure BandEP418Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDE

Slide19

Resulting Control Level

19

Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDECL5Highest risk levelRecommended measures :Full containmentSeek expert advice

Slide20

20

Recommended

measures for a Nano3 lab :Technical measuresVentilationExtract air filtrationSASOrganizational measuresWaste double packagingTrainingWritten proceduresPersonal measuresProtective equipmentsCleaningWet cleaningRisk Analysis – EPFL Method

Slide21

Prevention

/protection

measures at ISOLDERespiratory maskTyvek

suit2 pairs of glovesOvershoesGlasses

21

Slide22

Three different methods gave a similar

result : Risk

level is very highBut Protection measures are different : EPFL method - Fume hoodvs« Control Banding » - Full process enclosure + Expert adviceComparison between 3 methods22

Slide23

Nowadays :Toxicology of NPs are not

well knownExposure to

NPs is difficult to measureNext step for CERN : Choose one method and implement measuresFuture :Development of standards for Nanotechnologies → ISO TC 229 in progressOccupational risk managementISO/DTS 12901-1ISO/NP TS 12901-2Conclusion23

Slide24

24

Thank

you for your attention