PPT-Update on New Fluoroquinolones Boxed Warning & Increasing Fluoroquinolone Resistance

Jennifer Doan pharm D Pharmacy resident unity health September 30 2016 1 Learning Objectives Recognize potential fluoroquinolone toxicities that may occur with systemic fluoroquinolone use. 52 brPage 2br See Warnings and Precautions 52 see Description 11 see Warnings and Precautions 53 brPage 3br Glabellar Lines Lateral Canthal Lines brPage 4br see Warnings and Precautions 54 see Description 11 brPage 5br see Wa Over the last four years 2009 to 2012 resistance to third generation cephal osporins in K pneumoniae and E coli increased significantly at EUEEA level C ombined resistance to third generation cephalosporins and two other important antimicrobial gr 50 PAYMENT METHOD CIRCLE ONE Adult x 1000 Credit Card see attached form SubTOTAL Check payable to Brulee Catering prior to visit If applicable fax tax exempt form 8 Sales Tax TOTAL DUE x x x Orders must be placed at least 10 days in advance of --------------------------RECENT MAJOR CHANGES---------------------------- Boxed Warning 04/15 Indications and Usage (1.1) 04/15 Dosage and Administration (2.1, 2.2) 04/15 Warnings a Mark S. Johnson, . Pharm.D. ., BCPS. Associate Professor and Director of Postgraduate Education. Fluoroquinolones. Very popular class of antibiotics due to spectrum of coverage (gram positive, gram negative, . Sergey Kitaev. University of . Strathclyde. Permutations. . Permutations are considered in . one-line notation. , e.g. 526413. . The corresponding . permutation diagram. is. . . Classical patterns. % . survivors. Penicillin. Untreated. Days. Penicillin increased the chance of survival from 10% to 90%. Patients with. pneumonia . and bacteria . in the blood. Adapted from Austrian . et al.. Ann. Int. Med 1964; . Antibiotic Stewardship Program -ECHO. Update on Fluoroquinolones . Fluoroquinolone generations chart. Increased risk, greater than with most other antibiotics, for causing . C. difficile . colitis . Acute Tendonitis. % . survivors. Penicillin. Untreated. Days. Penicillin increased the chance of survival from 10% to 90%. Patients with. pneumonia . and bacteria . in the blood. Adapted from Austrian . et al.. Ann. Int. Med 1964; . 4. th. class \biology department . The Antimicrobial agents . Sulpha. drug &. Quinolones. . Prepared by. . Dr.Sawsan. . Sajid. AL-. Jubori. Dr.Saad. L. Hammed . Sulfonamide.  (also called . Antimicrobial resistance . Did we lose the magic bullet?. U. Theuretzbacher – . C. enter . f. or . A. nti-. I. nfective . A. gents, Vienna, Austria. Conflict of interest. Nothing to disclose. Self-assessment questions. and Urinary Tract. Antiseptics. I. FLUOROQUINOLONES. Nalidixic. acid is the predecessor to all . fluoroquinolones. , a class of man-. . made antibiotics. . Over 10,000 . fluoroquinolone. analogs have been synthesized, . Two patients with fever and cough. Viktor Kotarski. , MD. ID specialist. University Hospital for Infectious Diseases, Zagreb. Case . 1. 54. -year-old male patient. Additional . findings from 2014 study . Vladimirs. . Strazdins. , MD. Riga, Latvia. May 9, 2018. Background. – . resistant. E.coli. Antimicrobial . resistance. (AMR) . is. . growing. . rapidly.