PPT-Receptors Dr RESHMY K.R Professor

Dept of Physiology SKHMC Definition Sensory nerve endings that terminate in periphery as bare unmyelinated ending s Capsulated structures Biological transducers Convert various forms of energy into action potentials. Interest in dopamine was intensified by the realisation that dopamine had an important role in the pathogenesis or drug treatment of certain brain History diseases eg Parkinsons disease schizophrenia This lead to much research on the sites of action By Poppy and Jake. Intracellular receptors. Where are they?. What binds to them?. Intracellular (duh). Some are in the cytoplasm and some are in the nucleus.. Lipophillic. and hydrophobic ligands. E.g. Steroids (sex and . Main receptors. -. αβ. (Alpha &beta). - . γδ. (Gamma& delta). Co-receptors. -CD4&CD8 molecules. Co-stimulatory receptors. -CD28. Signal transduction molecules. -e, g, d . and . z. chains. Dr. SA . Ziai. Pharmacology. Pharmacology . can be defined as the study of substances that interact with living systems through chemical processes, especially by binding to regulatory molecules and activating or inhibiting normal body processes. . Pharmacodynamics. Seyed. Ali . Ziai. Receptor. Pharmacologic antagonists. Macromolecular Nature of Drug Receptors. Regulatory proteins. Enzymes. Transport proteins . Structural proteins. . Receptor- Effector Coupling. Receptor. A receptor is a protein molecule usually embedded within the cell membrane with part of its structure exposed on the outside of the cell.. The protein surface is a complicated shape containing hollows, ravines, and ridges.. Spinal cord. Transmits messages from the brain to the other areas of the body.. Efferent – away from the brain out to the body. Produces muscle action. Afferent – from the periphery to the brain. Cytokine Receptors. These are the receptors present on membrane of responsive . target cells by which cytokines binds to exert their biological effects.. Cytokine Receptors Fall Within Five Families. Exercise 20. BI 232. Introduction and Terminology. There are many types of sense receptors in the body.. They are not uniformly distributed. Punctate. distribution . is the pattern of uneven distribution throughout the body. Professor. Dept. of Physiology. SKHMC. Innervation of the Bladder. The principal nerve supply of the bladder is by way of the pelvic nerves, which connect with the spinal cord through the sacral plexus, mainly connecting with cord segments S2 and S3 Coursing through the pelvic nerves are both sensory nerve fibers and motor nerve fibers.. GPCR STRUCTURE AND FUNCTION G-protein-coupled receptors (GPCRs) or seven transmembrane domain receptors (7TM) comprise the largest superfamily of proteins in the body. In 6 Figure 1: Diversity Professor. Dept.of Physiology. SKHMC. RED NUCLEUS. A large, well defined, elongated cell mass of reddish-gray hue that is located in the . mesencephalic. . tegmentum. , . Receives a massive projection from the . . by . Dr.Vani. Gupta. Homeostasis. Homeostasis. - maintaining internal stability within an organism and returning to a particular stable state after a fluctuation.. K.R. Professor. Dept. of Physiology. SKHMC. Auditory pathway. The fibers of auditory pathway pass through . Cochlear division of . vestibulocochlear. nerve( VIII Cranial nerve).. It lies in the medulla oblongata, midbrain and thalamic region..