Faculty Department of Veterinary Medicine Introduction Babesiosis is tick transmitted haemoprotozoan infection of cattle buffalo horse sheep goat dog pig and wild animals characterized by fever anaemia ID: 912171
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Slide1
Babesiosis
Dr.
Pallav
Shekhar
Faculty
Department of Veterinary Medicine
Slide2Introduction
Babesiosis is tick transmitted
haemoprotozoan
infection of cattle, buffalo, horse, sheep, goat, dog, pig and wild animals characterized by fever, anaemia,
haemoglobinaemia and haemoglobinuria.
The Babesia is divided into two groups
Large form: 2.5 to 5
long
Small form: Less than 2.5
long
Shape and angle
Pyriform(Pear Shaped) rounded
Oval or bizarre in structure
The angle between the two parasite in large form is acute and in small form is obtuse.
Slide4Host and Babesia species
Animal
Species involved
Cattle, buffalo
Horse
Sheep
Pig
Dog
Cat
Babesia bigemina; Babesia bovis; Babesia divergens; Babesia major.Babesia equi; Babesia caballi.Babesia motasi; Babesia ovis.Babesia trautmanni.Babesia canis; Babesia gibsoni.Babesia felis.
Slide5EpidemiologyBabesia parasite has been placed on record for the first time by Babes in 1888 from blood from African cattle.
Babesia is present world wide.Diseases has been reported in all breeds of cattle but crossbred are more commonly affected. Young age cattle are highly susceptible.Babesia infection is reported in BuffaloesBabesiosis is reported from 2 days to 1month old calves.
Slide6Mode of Transmission
The disease is transmitted under natural conditions from affected to healthy animals through ticks.
Boophilus microplus and B.
annulatus are the major vectors of bovine babesiosis in India. In horse, Dermacentor,
Hyalomma and Rhipicephalus are responsible for transmission of both Babesia spp.
Babesiosis is also transmitted by Rhipicephalus,
Haemaphysalis
,
Dermacentor
and Ixodes ticks. Canine babesiosis is transmitted by the ticks of the genera Rhipicephalus, Dermacentor, Hyalomma and Haemaphysalis. In general, the disease is transmitted transovarially or trans-stadially.
Slide7Pathogenesis
Babesia – RBC- Intravascular haemolysis
Proteolytic enzymes- infected erythrocytes - increased erythrocytic fragility- hypotensive shock - disseminated intravascular coagulation
Coating of R.B.C. by parasitic antigen- autoagglutination of R.B.C.
Parasitaemia, fever and haemoglobinuria are the main clinical attributes.
Death occurs due to anaemic anoxia.
Slide8Clinical Signs
High fever
Anorexia,
Depression
Weakness.
Severe jaundice and haemoglobinuria.
Marked anaemia
Slide9In dog, five forms of the disease may be encountered.
Alimentary form - Characterized by stomatitis, gastritis and enteritis.
Respiratory form - Characterized by respiratory distress (dyspnoea).
Circulatory form - Characterized by oedema.
Ocular form - Characterized by keratitis and iritis.
Muscular form - Characterized by muscle weakness.
Atypical signs like convulsion, locomotor disturbance, ascites, dyspnoea, cough, enlarged tonsils and bleeding from nostril.
Slide10Disease has also been classified as (a) complicated from and (b) uncomplicated form
Complicated from in dog.
This results due to haemolytic process. Complications comprise of acute renal failure, cerebral signs, coagulopathy, icterus, hepatopathy, immune mediated haemolytic anaemia, acute respiratory distress, haemoconcentration, hypotension, cardiac involvement and pancreatitis.
Uncomplicated form in dog.
Acute haemolysis, fever, anorexia, depression pale mucous membrane, splenomegaly and water hammer pulse. This from may exist mild, moderate and severe depending on the severity.
In horses, haemoglobinuria is rare in occurrence and jaundice is more common, hence it is known as
“biliary fever”
.
Slide11Diagnosis
Haematology
There is severe anaemia.
There is increased leucocyte count associated with moderate neutrophilia.
There is presence of albumin and bile pigment in the urine
There is increased level of SGPT, BUN and Creatinine
Blood smear examination
ELISA
PCR
Slide12By Alan R Walker - Own work, CC BY-SA 3.0, https://
commons.wikimedia.org
/w/
index.php?curid
=19032008
Slide13Treatment
B.
canis
,
B. rossi, and B.
vogeli
are most successfully treated with
Diminazene
aceturate (3.5 mg/kg subcutaneously or intramuscularly)
or Imidocarb dipropionateDog ( 3-6.6 mg/kg twice, 14 days apart, SC)Babesia bigemina in Cattle Imidocarb (1mg/kg body weight)
Slide14Treatment
B. bigemina and B. major (large species) are more sensitive to drug and require low doses.
B. gibsoni can be treated with
atovagnone @ 13 mg/kg orally and azithromycin @ 10 mg 1 kg orally for 10 days (
Lobetti 2004).
Slide15For B.
gibsoniinfection
B. gibsoni, diminazene aceturate often fails to eliminate parasites. Attempts to sterilize infections using triple antibiotic combinations: doxycycline (5 mg/kg, orally, twice daily), clindamycin (25 mg/kg, orally, twice daily), metronidazole (15 mg/kg, orally, twice daily) doxycycline (7–10 mg/kg, orally, twice daily), enrofloxacin (2–2.5 mg/kg, orally, twice daily), metronidazole (5–15 mg/kg, orally, twice daily) i