Prof David Watters Deakin University and Barwon Health Director of Surgery Safer Care Victoria April 2023 Madeline Miller Washington Post 9 August 2023 Long covid has derailed my life ID: 1038736
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1. Immune biology and multisystem impact of long covidProf David Watters Deakin University and Barwon HealthDirector of Surgery, Safer Care Victoria
2. April 2023
3. Madeline Miller Washington Post, 9 August 2023“Long covid has derailed my life…..”
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5. Long COVID Sequelae and ComorbiditiesAutonomic Dysfunction (POTS) – orthostatic intoleranceThrombotic stroke and TIANeurodegenerative diseaseCognitive impairmentSpeech and language difficultiesImpaired lung function and scarringNew onset/exacerbation of asthmaNew onset diabetes/ Deteriorating glycaemic controlIncreased post COVID-19 mortality assoc with diabetes, HT and obesityImpaired kidney function, deterioration of existing CKI and dialysisEndothelial dysfunction and ThrombosisMental Health disorders Fatigue and Impaired work/study capacity
6. Possible Immunobiological Causes of Long Covidand/or Direct interaction/inhibition of SARS-CoV2 with critical mitochondrial proteins
7. Post COVID hospital admissions in VictoriaRowe SL, Leder K, Dyson K, Sundaresan L, Wollersheim D, Lynch B, Abdullahi I, Cowie BC, Stephens N, Nolan TM, Sullivan SG, Sutton B, Cheng AC. Associations between COVID-19 and hospitalisation with respiratory and non-respiratory conditions: a record linkage study. Med J Aust. 2023 Jan 16;218(1):33-39.
8. Major Medical Conditions within 12 months of COVID-19ICUCohortPro-atherogenic inflammatory responses in plaques – infected with Covid-19
9. SummaryLong Covid results in many different symptoms affecting every major body systemFatigue, brain fog (cognitive impairment) and breathlessness are 3 of the most frequent symptomsMental health issues are frequent and previous mental health problems may be made worseImpact on pre-existing comorbidities and onset of new comorbiditiesThere are markers of immune dysfunction that persist up to two years after COVID-19, especially in those with long covid symptomsCOVID-19 viral particles persist in lung, brain and gut long after COVID-19Autoimmunity may play a role in long covidOther (latent) dormant viruses may be re-activated including Epstein-Barr virus