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Addressing the Unmet Need in Nonalcoholic Steatohepatitis Addressing the Unmet Need in Nonalcoholic Steatohepatitis

Addressing the Unmet Need in Nonalcoholic Steatohepatitis - PowerPoint Presentation

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Uploaded On 2016-08-04

Addressing the Unmet Need in Nonalcoholic Steatohepatitis - PPT Presentation

NAFLD Hepatic Manifestation of Metabolic Syndrome a NAFLD cont Hepatic Manifestation of Metabolic Syndrome a NAFLDNASH Closely Associated With Visceral Obesity Insulin Resistance AASLD ID: 433291

insulin nafld cont references nafld insulin references cont improves sensitivity loss weight aid inhibits nash hepatic syndromea metabolic manifestation

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Presentation Transcript

Slide1

Addressing the Unmet Need in Nonalcoholic SteatohepatitisSlide2
Slide3

NAFLDHepatic

Manifestation of Metabolic Syndrome

aSlide4

NAFLD (cont)

Hepatic

Manifestation of Metabolic Syndrome

aSlide5

NAFLD/NASH Closely Associated With Visceral Obesity, Insulin ResistanceSlide6

AASLDCurrent Therapeutic Recommendations for NAFLD/NASHSlide7

Pioglitazone vs PlaceboSignificant Improvement of Histologic Features and Insulin SensitivitySlide8

11β-HSD1 Inhibitor RO5093151 Inhibits Adipocyte DifferentiationSlide9

Galectin-3 Binding Drug GR-MD-02 Inhibits Hepatic Injury in Mouse ModelSlide10

Obeticholic Acid Improves Insulin Sensitivity and Markers of Liver InjurySlide11

Selective Serotonin 2C Receptor Agonists Aid Weight LossSlide12

Phentermine and Topiramate ER, an STR, Improves Weight LossSlide13

Incretin Mimetics and Analogs Aid Maintenance of Glucose BalanceSlide14

AbbreviationsSlide15

ReferencesSlide16

References (cont)Slide17

References (cont)