Arend Sidow PhD Professor Departments of Pathology and Genetics Stanford An introduction that includes the most important concepts in Genetics and Genome Biology 1 Genotype Phenotype Genetic Testing ID: 685371
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Slide1
Genetic Testing in the Genome Era
Arend Sidow, Ph.D.Professor, Departments of Pathology and Genetics, Stanford
An introduction that includes the most important concepts in Genetics and Genome Biology
1Slide2
Genotype
Phenotype
Genetic Testing
2
Biology*
Test
Predict
Genetic PredictionSlide3
Knowledge
Time
Concepts
Scientific Process:
Studies
Course Philosophy and Emphasis
3
Course emphasisSlide4
Subatomic particles
AtomsOrganic molecules (carbon, hydrogen, oxygen, nitrogen, sulfur, phosphorous, and occasionally other elements)
MacromoleculesSubcellular compartmentsCells
Tissues
Organisms
Tribes and societies
Hierarchical Organization of Nature
Physics
Chemistry
Cell biology
Physiology
Culture
Functional Organization
Population Genetics
Evolution
Transmission Genetics
Information Inheritance
Individuals, families
Populations
Species
4
BiologySlide5
1cm
Scale of Cellular and Molecular Organization
Factory
Subdivision
Town
Machine
1nm
5
0.1mm
1mm
10µm
100nm
1µm
10nmSlide6
Course Content
Basics of Biology
Cell Biology: The Machinery
How cells are organized and work
Genetics: The Information
How the machinery is encoded in the genome and how the genome is inherited
Introductory
Content
Specific Content
6Slide7
Subatomic particles
AtomsOrganic molecules (carbon, hydrogen, oxygen, nitrogen, sulfur, phosphorous, and occasionally other elements)
MacromoleculesSubcellular compartmentsCells
Tissues
Organisms
Tribes and societies
Hierarchical Organization of Nature
Physics
Chemistry
Cell biology
Physiology
Culture
Functional Organization
Population Genetics
Evolution
Transmission Genetics
Information Inheritance
Individuals, families
Populations
Species
7
BiologySlide8
Course Content
Basics of Biology
Cell Biology: The Machinery
How cells are organized and work
Genetics: The Information
How the machinery is encoded in the genome and how the genome is inherited
DNA sequencing and related approaches
Sample Preparation
Chemistry
Bioinformatics
Introductory
Content
Specific Content
Genetic Variation and Disease
Variation and DiversityTypes of mutations and the dynamics of variation in the population(Molecular) phenotypes
What genetic variation does to The Machinery and how it causes disease
Genetic TestingTypes of testsTest interpretationTesting in the future8Slide9
Attributions
Slide
Content
Link to file
Attribution
5
HeLa cells
https://commons.wikimedia.org/w/index.php?curid=29540602
By National Institutes of Health (NIH) - National Institutes of Health (NIH), Public Domain,
5
Crowded cytosol
https://commons.wikimedia.org/w/index.php?curid=4762672
By TimVickers - Own work by uploader, based upon simlar illustrations in Goodsell DS (June 1991). "Inside a living cell". Trends Biochem. Sci. 16 (6): 203–6. DOI:10.1016/0968-0004(91)90083-8. PMID 1891800., Public Domain,
5
ATP synthase
https://commons.wikimedia.org/w/index.php?curid=1618502
By Alex.X - enWiki (PDB.org for coordinate), CC BY-SA 3.0, 5
ATPhttps://commons.wikimedia.org/w/index.php?curid=697142
Public Domain
9