Timetable for today Time Activity 0000 Introduction to the session 0010 Story cards 0020 Info cards 0030 Issue cards 0040 Discuss two key issues 0045 Feedback your issues What is DNA ID: 614985
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Slide1
Genome generationSlide2
Timetable for today
Time
Activity00:00Introduction to the session
00:10Story cards 00:20Info cards00:30
Issue cards00:40Discuss two key issues00:45
Feedback your issuesSlide3
What is DNA?Slide4
T
A
G
DNA’s code
CSlide5
What is a gene?
Coding
DNA
Non-coding
DNA
ProteinSlide6
What is a genome?Slide7
G
C
T
A
G
T
C
G
A
T
A
G
Genetic variation
C
C
T
A
G
T
C
T
A
T
A
G
CSlide8
Sequencing technologySequencing technology is advancing rapidly. In 10 years DNA sequencing will become part of routine medical screening.
Image
by Roy
Kaltschmidt, LBNL. Slide9
What is genotyping?Genotyping involves looking at particular regions of the genome that are known to vary between individuals.Information from genotyping can indicate:
disease riskdrug responsivenesscarrier status for disease
personal traits such as eye colour.
Image by Kat M Research, Flickr.Slide10
What is genome sequencing?Genome sequencing involves finding out the whole sequence of a person’s DNA.Commercially available personal genome sequencing currently costs between £6,000 and £12,000.
Image
courtesy of Wellcome Library, LondonSlide11
Genes vs environmentA predisposition means that people with a particular genotype tend to have an increased risk of developing a disease.
Lifestyle plays a significant role in increasing or decreasing the risk of developing some diseases.
Monogenic
Type 2 DiabetesObesity
Infectious Disease
Environment
GenesSlide12
Story cards (10 minutes)Slide13
What is pharmacogenomics?
What is schizophrenia?
The genetics of breast cancer
What are the risk factors for heart disease?
What is flucloxacillin? How much can genetics alone
really tell you? Are
personalised medicines the drugs of the future?
About the risk gene ApoE-e4
Genetic counselling Info cards (10 minutes)Slide14
Issue cards (10 minutes)
How would you feel…?
Who should know…?
But,
w
hat if…?
Is it right that…?
Is it better to know…?What would you do…?Slide15
Top issues (5 minutes)Decide what are the two top issues that come out of the scenario.Highlight these as they will be used in feedback session.Remember to write notes throughout the discussion.Slide16
Discussion guidelinesSpeak for yourself and not for others.Allow others to finish before you speak. Listen well.
Ask questions (???) as well as making statements (!!!)Explain what you think and feel.
Respect differences in opinion. Find where you agree.Share your life experiences and knowledge – it is valuable.Slide17
Genome generation