PPT-Retroviruses and the RW Genome –

Active Roles in Evolution of Immunity and Pregnancy Retroviruses 2015 Chicago June 8 2015 James A Shapiro University of Chicago jshauchicagoedu wwwshapirobsduchicagoedu Evolutionary time Genome writing . Mayo/UIUC Summer . C. ourse in Computational Biology. Session Outline. Genome sequencing. Schematic overview of genome assembly. (a) DNA is collected from the biological sample and sequenced. (b) The output from the sequencer consists of many billions of short, unordered DNA fragments from random positions in the genome. (c) The short fragments are compared with each other to discover how they overlap. (d) The overlap relationships are captured in a large assembly graph shown as nodes representing . Mayo/UIUC Summer . C. ourse in Computational Biology. Session Outline. Genome sequencing. Schematic overview of genome assembly. (a) DNA is collected from the biological sample and sequenced. (b) The output from the sequencer consists of many billions of short, unordered DNA fragments from random positions in the genome. (c) The short fragments are compared with each other to discover how they overlap. (d) The overlap relationships are captured in a large assembly graph shown as nodes representing . (as told by Michael Lynch). Genome size and complexity varies across the tree of life. Lynch 2007. Some Big Questions. What is the relationship between genomic and organismal size/complexity?. Are genome size changes adaptive, or passively acquired?. shinisaurus. . crocodilurus. Jian . gao. , . qiye. li, . zongji. . wang. , yang . zhou. , . paolo. . martelli. , fang li, . zijun. . xiong. , . jian. . wang. , . huanming. yang, and . guojie. . (before and after 2015). Second International Summit on Human Genome Editing . The University of Hong Kong . November 27-29 2018 . India specific Actions . And Advisory Options Related Human Genome Editing. Key considerations:. Genes . Chromosomes. C value paradox. Gene regulation. Epigenetics. Transposable elements. DNA . ……..……..mRNA……….…….Protein . Plant . Estimated # genes. Arabidposis. Key considerations:. Genes . Chromosomes. C value paradox. Gene regulation. Epigenetics. Transposable elements. DNA . ……..……..mRNA……….…….Protein . Plant . Estimated # genes. Arabidposis. Derek M Bickhart . Animal Genomics and Improvement Laboratory . Research Geneticist (Animal) . derek.bickhart@ars.usda.gov . Phone: (301) 504-8679 Fax: (301) 504-8092. USDA disclaimer. Disclaimers: Mention of trade names, commercial products, or companies in this publication is solely for the purpose of providing specific information and does not imply recommendation or endorsement by the US Department of Agriculture over others not mentioned. . Matthew L. Speir. 1. , Angie S. Hinrichs. 1. , Maximilian Haeussler. 1. , Brian J. Raney. 1. , Hiram Clawson. 1. , Kate R. Rosenbloom. 1. , Galt P. Barber. 1. ,. Jonathan Casper. 1. , Steve Heitner. 1. Kesheng Wang, PhD. Department of Biostatistics and Epidemiology. College of Public Health. East Tennessee State University. 2. Outline. Introduction . Alcohol dependence (AD). Genetic study. . Subjects and Methods. [22]. The pattern of blocks was assessed to see whether theirarrangement in the ancestral genome prior to duplicationarrangement in the ancestral genome prior to duplicationequally parsimonious series Martella V, Pinto P, Lorusso E, Di Martino B, Wang Q, Larocca V, et al. Detection and Full-Length Genome Characterization of Novel Canine Vesiviruses. Emerg Infect Dis. 2015;21(8):1433-1436. https://doi.org/10.3201/eid2108.140900. Lisa Scheifele, Loyola University Maryland. Timeline of synthetic genes and genomes. Endy . Science. 319:1196. The process of genome synthesis. Edit and make changes. Creation of synthetic life. Assemble genome of . . Knowing how many genes determine a phenotype (Mendelian and/or QTL analysis), and where the genes are located (linkage mapping) is a first step in understanding the genetic basis of a phenotype . A second step is determining the sequence of the gene (or genes).