PPT-Viral Replication 5 th Lecture

Viral Replication Viruses multiply only in living cells As viruses are obligate intracellular pathogens they cannot replicate without the machinery and metabolism of a host cell The host cell must provide the energy and synthetic machinery and the lowmolecularweight precursors for the synthesis of viral proteins and nucleic acids . Algorithmic Warm-Up. Phillip . Compeau. and Pavel Pevzner. Bioinformatics Algorithms: an Active Learning Approach. ©2013 . by Compeau and Pevzner. All rights reserved . . Before a C. ell . D. ivides. Andrey Grigoriev. Director, Center for Computational and Integrative Biology. . Rutgers University. 2. What are we going to do?. Observe effects of fundamental processes. Estimate their relative contribution. By . Shruti. . poundarik. Data Objects and Files are replicated to increase system performance and availability.. Increased system performance achieved through concurrent access of replicas.. High availability of data due to redundancy of data objects.. Topics. Why Replication?. System Model. Consistency Models . One approach to consistency management and dealing with failures. Readings. Van Steen and Tanenbaum: 6.1, 6.2 and 6.3, 6.4. Coulouris: 11,14. Presented by . Paul Ibison. IT Technical . Specialist . creator of . www.replicationanswers.com. . responsible for PayPal and EBay replication implementation. © . 2012 Paul Ibison. . All rights reserved.. Murtadha Al Hubail. Project Team:. Motivation & Goals. NC 1. Cluster Controller. NC2. NC3. AsterixDB typical cluster consists of a master node (Cluster Controller) and multiple node controllers (NC).. WHAT YOU WILL LEARN. -process of DNA making copies . -role of enzymes in copying DNA. -leading and lagging strands in DNA replication. READING Q. ’. s . 1-LIST:. -the 3 phases of semi-conservative replication. IV - REPLICATION MANAGEMENT. . By Jyothsna Natarajan. Instructor: Prof. Yanqing Zhang. Course: Advanced Operating Systems (CSC 8320) . What is Replication?. Replication is the process of having multiple copies of identical data and computations in distributed systems. . Learning Objectives. What happens during DNA replication?. How is a new polynucleotide strand formed?. Why is DNA replication known as ‘semi-conservative’?. Putting What We’ve Learnt So Far In To Context.... Objectives:. 1. Summarize the roles of the different enzymes involved in replication of DNA.. 2. Explain how the leading and lagging strands are replicated differently . Semiconservative. Replication. The function of DNA in the cells is to. preserve genetic information.. transfer genetic information to new cells as the strands of DNA are copied.. DNA Replication. In . DNA replication. ,. the strands in the original or parent DNA molecule separate to allow the synthesis of complementary DNA strands.. In . their 1953 announcement of a double helix structure for DNA, Watson and Crick stated, . "It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material.". . PATHOGENESIS. The. . study. . of. . viral. . pathogenesis elucidates. . this. . special. . relationship. . between. . the. . virus. . and. . the intact. . host.. . The. . term. .  . Antigenic drift. . where individual bases in the DNA or RNA . mutate. to other bases. Most of these . point mutations. are "silent" – they do not change the protein that the gene encodes. .