PPT-How do Replication and Transcription Change Genomes?

Andrey Grigoriev Director Center for Computational and Integrative Biology Rutgers University 2 What are we going to do Observe effects of fundamental processes Estimate their relative contribution. Replication,. Transcription, & Translation. . DNA Replication. DNA Replication. . Before a cell can divide by . mitosis. or . meiosis. , it must first make a copy of its . chromosomes. .. The . Central Dogma of Biology. Information flows from . DNA .  RNA  Proteins. Think of it as exchanging money in a different country: proteins cannot be built directly from DNA. Three main processes involved:. & . Genome evolution. Genomes and Genome Evolution - BIOL 4301/6301. What to expect and some suggestions.. I . like think . of . myself as . fair but reasonably tough. I want people to do well but I’m not willing to compromise on the material or ethical guidelines to make it happen.. SC.L.16.3 . Describe . the basic process. of . DNA replication . and how it relates . to the . transmission . and . conservation. of . the genetic information. DNA and Its structure. DNA (deoxyribonucleic acid) is a large organic. Colon with cancerous polyps. http://www.humpath.com/colonic-dysmotility&id_document=23133. http://www.aboutcancer.com/genetic_colon_cancer.htm. Transcription gone bad…. Teaching Unit: . Transcription. A . PuhJayJay. Presentation . Daily Catalyst . 1. If there are 34% of Adenines in DNA, what is the percentage of . uracil. in RNA?. 34%. 2. .   . Replicate. the following segment of DNA:.     5’- ATCGGCTACGTTCAC  -3’. Chapters 12 & 13. The Role of dna. Stores Information. Keeps the instructions that make you look and act the way you do. Copies Information. During cell division you have to copy the DNA before the cell can split. Chargaff's rule. states DNA of any species contains equal amounts of guanine and cytosine and also equal amounts of adenine and thymine. . This pattern is found in both strands of the DNA. . They were discovered by Austrian chemist Erwin Chargaff. . The genome . of the infecting virus is replicated so that . viral transcription . can be amplified and to provide copies . of the . genome for progeny . virions. .. Generally, DNA viruses copy their genomes . . REPLICATION – GENERAL PRINCIPLES. START. Must be ready . Must know where to start . FINISH. Must all finish . Must ensure that each piece of DNA is replicated only once . Therefore must know where to finish . Transcription, translation and transport. Transcription of virus genome. In the summary of the scheme depicted . below, most . of the nucleic acid strands are . labelled. (+) . or (. −). This . labelling. Griffith finds a ‘transforming principle.’ . Griffith experimented with the bacteria that cause pneumonia.. He used two forms: the S form (deadly) and the R form (not deadly).. A transforming material passed from dead S bacteria to live R bacteria, making them deadly.. Transcription, translation and transport. Transcription of virus genome. In the summary of the scheme depicted . below, most . of the nucleic acid strands are . labelled. (+) . or (. −). This . labelling. Mitosis, Protein . Synthesis. Week 8. 9/29 . DNA Replication . 11.1. Obj. TSW demonstrate base pairing rules of DNA Replication by constructing a 2-D model of DNA with paper. . P. 68 NB. Replication Video.