PPT-Cytoskeleton Ribosome Protein folding

mRNA processing Lipid transport Transcription Cell growth Cytoskeleton Carbohydrate metabolism Protein catabolism Electron transport Ribosome Cytoskeleton Protein catabolism Cell adhesion. Muhammad Shoaib Amjad. 11-Arid-3758. PhD Botany. WHY PROTEIN FOLDING?. Most proteins must fold into defined three-dimensional structures to gain functional activity. . The classic principle of . protein folding. is that all the information required for a protein to adopt the correct three-dimensional conformation is provided by its amino acid sequence.. Molecular chaperones. Jan 2012. Regulatory Genomics. Lecturer: Prof. Yitzhak Pilpel. Selection of codons might affect:. Accuracy. Throughput. Costs. Folding. RNA-structure. C. c. d. dC. cC. Fo. d*C. c*C. Free energy. l’c. DNA .  RNA  Protein. 2 Major Steps. Transcription. – DNA is transcribed (copied!) into single stranded mRNA . (DNA code transcribed into RNA code). Translation. – mRNA is translated into protein (amino acids). Network of Protein Filaments. Used in:. Structural Support. Cell Movement. Movement of Vesicles within Cells. Composed of three types of Cytoskeletal fibers. Actin Filaments. Microtubules. Intermediate Filaments. Chris Garlock. Protein Folding - Why is it important. Proteins are biological nano-machines which play apart in all of our bodies functions. Protein folding is the process all proteins undergo to assemble into their native structure. The cytoskeleton is a network of protein fibers within a cell, that crisscross the cytoplasm of all eukaryotic cells. The cytoskeleton is a very dynamic system that is constantly assembling and . dissembling. . Stolen and Edited by: Keith King. Objectives . Review central dogma of molecular biology. . Discuss type of protein.. Assess amino acids.. Demonstrate folding proteins.. protein folding video. Review – Central Dogma of Molecular Biology . and protein molecules. Consists of a large and a small subunit.. Ribosomal . RNA. RNA molecule that, together with protein, make up ribosome.. Protein. A biologically functional molecule consisting of one or more polypeptides folded and coiled into a specific three-dimensional structure.. By: Tim Yacoub and Lizette Magdaleno . Cytoskeleton Overview. Cytoskeleton is a “network of fibers that extend[s] throughout the cytoplasm,”(113). . It’s three structures: microtubules, microfilaments, and intermediate filaments. Advisor: Dr. Chen . Keasar. Arie Barsky, Nadav Nuni. Protein folding problem. Proteins are responsible for constructing and operating the organism, and are made of chains of amino-acids. Protein folding problem. DISEASES.  . How . Proteins . fold and why they . misfold. Role of Molecular Chaperones in Protein Folding . ORGANELLE-SPECIFIC PROTEIN QUALITY CONTROL SYSTEMS AND PROTEIN MISFOLDING DISEASES. Mechanisms and Link to Disease . Mechanism of folding and . misfolding. GroEL. – biological machine (chaperones folding). Molecular motors: Polymer physics and Myosin V motility. Many Facets of Folding . Structure Prediction. Protein & Enzyme Design. This has proved to be a very challenging problem. It has aptly been described as the second half of the genetic code, and as the three-dimensional code, as opposed to the one-dimensional code involved in nucleotide/amino acid sequence. .