PPT-Diagnostic Approach of Acromegaly

Mahtab Niroomand M D Assistant Professor of Endocrinology 2014 Tehran Out line Introduction and epidemiology Etiology and differential diagnosis Clinical features Survival Diagnostic modality. Practical Endocrinology. Wendy Blount, DVM. The Pituitary Gland. Two parts. Adenohypophysis – anterior lobe. Pars distalis. Pars intermedia. Pars infundibularis. Neurohypophysis - posterior lobe. Growth Hormone (GH) = Somatotropin. Sayed. Abdel Fattah . Eid. Lecturer of Internal Medicine. Delta University. Acromegaly . . Introduction. - Acromegaly is an insidious disorder caused by a pituitary GH-secreting adenoma resulting in high circulating levels of GH and IGF-I. . An information session for Superannuation Fund Trustees and Administrators. Presented by . David Taylor, Australian Taxation Office . / 21 March 2016. Overview . Introduction 5 mins. Large fund compliance approach 5. Practical Endocrinology. Wendy Blount, DVM. The Pituitary Gland. Two parts. Adenohypophysis – anterior lobe. Pars distalis. Pars intermedia. Pars infundibularis. Neurohypophysis - posterior lobe. Growth Hormone (GH) = Somatotropin. Acromegaly. Very rare. Prevalence in the order of 1 in 200,000. Usually diagnosed between age 40 and 60. No difference in gender susceptibility. Insidious onset. Pathogenesis. Most commonly caused by pituitary adenoma. . therapeutic outcomes. . Fatemeh Rahmani. Agenda. . . 1.Introduction. 2.TherapeuticEnd-Points . ■ . BiochemicalGoals. ■ . Tumor Shrinkage . Acromegaly. Rahim. . Zahedi. MD. Introduction. Acromegaly. is a rare disease typically caused by an excess of growth hormone (GH) secretion from a pituitary adenoma. The active disease is characterized by elevations of both GH and insulin-like growth factor-1 (IGF1) and the failure of GH suppression in oral glucose tolerance test(OGTT). Batoul. . B. irjandi. Patients with MAS have a somatic (. postzygotic. ) mutation of the alpha subunit of the . G . protein that activates adenylyl . cyclase. . . . This mutation leads to continued stimulation of endocrine function (. • Today . the pituitary gland is recognized for its . essential role . in body homeostasis, and for this reason it often is referred . to as . the “. master gland. .”. • The pituitary . is a very small gland, weighing between 0.4 and 1 g . 395 respiratory or cardiac failure. Among them, cardiovascular involvement is a leading cause of morbidity and mortality. There are relatively few cases reporting cardiac pISSN 2384-1095eISSN 2384-11 Past, Present and Future. Consultant Endocrinologist, . The Christie Hospital NHS FT. Honorary Senior Lecturer, . University of Manchester . SfE. BES 2022- Conflict Of Interest . Acromegaly is caused by . axcess growth . hormone (GH) secretion . due . to a GH secreting pituitary tumour (. somatotroph. . adenoma) usually . a . macroadenoma. .. GH excess . produces . gigantism in children (. Sheila Khawaja. 1. , Muriël Marks. 1. , Mark Gurnell. 2. , Maria Fleseriu. 3. . 1. World Alliance of Pituitary Organizations, Zeeland, Netherlands; . 2. Wellcome-MRC Institute of Metabolic Science, University of Cambridge & Addenbrooke’s Hospital, Cambridge, UK; . Prolactinoma. . (on medical treatment) was referred to endocrine clinic for high IGF1 level and impaired GH-GTT test. Presented by Suzan . Maleki. MD. 2023 JAN. Patient ID. 41 y/o man. From . Amol.