PPT-Immunoglobulins and

Immunoglobulin Genes immunoglobulins The two hallmarks of immunoglobulins as antigenbinding proteins are the specificity of each for a particular epitope target and their diversity as a group In addition to antigen binding however . Dr. . Nasim. PGT Biochemistry. Antibodies. Proteins that recognize and bind to a particular antigen with very high . specificity. .. Made in response to exposure to the antigen.. Each antibody has at least two identical sites that bind antigen: . Ali Al Khader, MD. Faculty of Medicine. Al-Balqa’ Applied University. Email: ali.alkhader@bau.edu.jo. Immunoglobulins (Igs). = antibodies. Each B cell synthesizes Igs of single specificity for a specific epitope. Recall Structure . Numerous V region genes are preceded by Leader or signal sequences (60-90 . bp. ) . exons. interspersed with . introns. .. Heavy chain contains . V (Variable), D . (Diversity), . J (Joining) and C (Constant) . Cells of the Immune System. Physical & Chemical Barriers. Innate and Adaptive Immunity. Innate Defenses. Nonspecific physical and chemical barriers that contribute to resistance against infection. WHO Essential . Medicines. List . Animal (equine) derived blood products . Snake anti-venom immunoglobulins . Anti-rabies imunoglobulins. Anti- tetanus immunolglobulins. Anti-diphtheria immunoglobulins. David Lowe. Royal Free Hospital / University College London. Or…. Suspecting primary immunodeficiency. AND. Suspecting secondary . hypogammaglobulinemia. Primary immunodeficiency (…in adults). Antibodies / B cells. - Definition, Structure & Function, . Classes of . Immunoglobulins. ).. - Antibodies . are . glycoprotein . molecules that . recognise a . particular . epitope. on . an antigen. , bind specifically . - . ontogenesis. , . surface. . markers. , . function. . . . Ontogenesis. . of. . antibody. . production. .    . 16. . Immunoglobulins. (. structure. , . classes. ). . Genetic. . background . Dr. . Vinod. K.V.. Also known as antibodies. They are . glycoproteins. produced by the body against antigenic stimulus. Synthesised by B lymphocytes. Basic structure. Igs. are . glycoproteins. Made up of two pairs of polypeptide chains. Lec.4. . Dr. Mustafa Jawad. Definition of Immunoglobulins (Igs). Immunoglobulins, also known as . antibodies. , are glycoprotein molecules produced by . plasma cells . (B-cell). . They . act as a critical part of the immune response by specifically . Martin Liška. 1. The structure of immunoglobulins. 2. Isotypes. (in principle) classes of antibodies distinguished on the basis of H chain structure differences. 5 types: . m. (IgM), . d. (IgD), . also known as antibodies, are glycoprotein molecules produced by plasma cells (white blood cells). They act as a critical part of the immune response by specifically recognizing and binding to particular antigens, such as bacteria or viruses, and aiding in their destruction..