Body Systems Skeletal Muscular Digestive Circulation Nervous Respiratory Dermal Reproduction Lymphatic Detoxification Immune Regulatory The Detoxification System The process of metabolizing ID: 779369
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Slide1
I A B P
Copyright 2000 IABP, Inc.
Slide2Body Systems
Skeletal Muscular
Digestive CirculationNervous RespiratoryDermal Reproduction
Lymphatic DetoxificationImmune Regulatory
Slide3The Detoxification System
The process of metabolizing
Hydrocarbons and
Mycotoxins within the body.
Slide4Hydrocarbons can be synthesized from coal and petroleum.
They are known as:
Petrochemicals or foreign chemicalsVolatile Organic Hydrocarbons – VOCsAliphatic Hydrocarbons
Aromatic HydrocarbonsFormaldehyde, Aldehydes, CyanidesReferred to as “Xenobiotics”.
Slide5Mycotoxins
Natural poisons from molds and fungus on foods and in the air.
Involved in decomposition processes.Metabolized byproducts from within the body.
Slide6There are currently no universally accepted tests available to determine xenobiotic toxicity.
Patient Indicators:
Allergic Responses – Asthma, Histamine ReleaseFatigue – Exhaustion, Tired upon rising
Memory – Lapses, short-term and long-termSleepy – Tired in afternoon or after sleepingSkin Reactions – Rashes, Eczema, HivesAutoimmune – Hyper-Responsive
Nerves – Disorders, depression, impaired motor function
Brain – Cognition, attention span, speech center, emotions
Physiology – Agitation, anxiety, menses, cravings, addictions
Slide7Situation
A person visits the doctor complaining of various symptoms. The doctor often has limited means for understanding exactly what the cause is.The person is desperate to find someone who knows how to solve the problem(s).
Slide8Common Names
Multiple Chemical Sensitivity – MCS
Allergic ReactionUniversal ReactorEnvironmental Illness
Slide9Clinical Ecology-Accepted Test
Provocative Neutralization developed by Dr. Theron Randolph.
Proven theory based on homeopathic principles and research by Dr. Jaques Benveniste.
Slide10Common Therapy
:
Cortisone Antihistamines Antidepressants
Steroids
Slide11Xenobiotics are introduced through:
Skin Breathing Ingestion
Metabolic byproducts
Slide12If you can smell it, it has already entered the bloodstream!
Dopey
DizzySpaceyUnable to concentrate
Slide13Common Chemical Exposures
Trichloroethylene -- TCE
BenzeneToluene Phenol
XyleneStyrene
Slide14Benzene-Toluene-Phenol-Xlyene
Known causes of leukemia
Lipid-soluble chemicalsEasily pass into lipid cell membranesEasily pass into blood stream after inhaling
Special affinity for the brain, a lipid rich organ.
Slide15Common Symptoms
Depression
ExhaustionDizzinessHeadache
Inability to think clearly
Slide16Analysis of air over vinyl floor
Toluene Benzyl Chloride
Phenol Benzol ChlorideTrichloroethane Benzyl Butyl EtherBenzaldehyde Decanol
Butanol 1-(2-butoxy ethoxy)Hexanol 2-butanone - ethanolCyclohexanone
Slide17Common Chemicals in Carpet
FormaldehydeTolueneXylene
BenzeneMethacrylateTetrachloroethyleneMethyl Naphthalene
Slide18Common Symptoms of Trichloroethylene Exposure
Poor Concentration Confusion
Poor Coordination HeadacheUndue Fatigue DizzinessDrowsiness Muscle Cramps
Slowed Responses Slowed DecisionsNumbness, Tingling
Slide19Common products containing
Trichloroethylene
Solvents in machines and oilsDry cleaning fluid on clothesCarpet shampoo
Floor polishCopy Machines -- outgasGluesCorrection fluid
Slide20Hospital Air Analysis
Acetone Acrolein AmmoniaBenzene Carbon Dioxide ChlorineMercury Ethylene Oxide Methane
Phenols Formaldehyde NitrogenOzone Phosphates HydroxidesStyrene Sulphur Compounds TolueneXylene Nitrous Oxides
Slide21Exhaled Breath Analysis
355 New Jersey Urban Residents -1984
Chloroform TrichloroethaneBenzene StyreneO-xylene Xylene
Dichlorobenzene TrichloroethyleneTetrachloroethylene Carbon Tetrachloride
Slide22Yeast and Fungus
Body creates antibodies against the yeast and molds in the gut.
Byproducts create mycological toxinsAntibodies stimulate histamine release. Responses in body are allergic in nature.Candida Albicans create acetaldehyde.
Puts pressure on the detoxification paths.
Slide23Candida Albicans
Over 500 known symptoms
Adds to allergic burden and toxic loadCreates mycological toxinsCauses sugar cravings
Can live in acid terrain, caused by amalgams and pesticides.
Slide24Healthy Gut Flora
Reduces aldehydes, ketones, alcoholsHydrolysis of glucuronides, sulfates, oxides and esters.Dehydroxylation of C- and N-Hydroxy compounds
DecarboxylationDehalogenation
Slide25The Detoxification System
Housed in every cell of the body.
Used as a defense system for poisons.Understanding this system holds the key to clearing previously impossible to address conditions.
Slide26Metabolized Process
Functional process has limits based on resources.
May biotransform into other toxins that are worse.Detoxification process to adapt to the toxin.
Slide27Once in the the blood stream
The body then has two goals for chemical poisons:
Make the chemicals less poisonous.
Excrete them as quickly as possible.
Slide28Phase - I Detoxification
Liver Function
Endoplasmic Reticulum -- Cytochrome P-450 Oxidation
Reduction Hydrolysis
Slide29Phase I (E R) - Responses
Oxidation / Reduction / Hydrolysis
Burning off an electron, adding an electron, or removing hydrogen from the original compound. If this is successful, excretion by the kidneys can occur.
Slide30Phase II - Conjugation
Cytoplasm of the cell -- Cytosol
Polarization of the chemical by adding amino acid or protein, which changes the charge and increases the odds of excretion through the bowel.
Slide31Conjugation with
Glutathione (GSH)
Predominant process using glutathione, which is comprised of:Glutamic AcidCysteine
Glycene
Slide32GSH - Glutathione
If there is insufficient GSH available due to Phase II detoxification, then other systems that need GSH are weakened.
Slide33Phase II Detoxification Cont.:
Glycene and Cysteine Conjugation
Requires SulphurGlucuronic Acid ConjugationRequires Zinc
PAPS - Conjugation3’Phosphoadenosine, 5’PhosphoadenoseneRequires Cysteine
Slide34Biotransformaton or Detox?
Enzymes-- specialized proteins Reaction specific-may or may not aid in detoxification or biotransformation: - If the enzyme has the key to the problem, it will.
- On the other hand, if the enzyme can’t be activated due to vitamin or mineral deficiency, it won’t.
Slide35Phase - II Detoxificaton
Comprised of Twelve Pathways
Genetics -- What enzymes are available?Nutrient Levels -- Vitamins, Minerals, Amino Acids, Essential Fatty Acids.Total “Load” -- How many chemicals are already in the body? Subsequent exposures?
Detox Damage -- Which pathways cannot be used due to previous damage?
Slide36Problems associated with impaired detox pathways:
Toxins attach to the liver and kidneys.
Toxins attach to GSH.Irreparable damage to a detox pathwayToxins attach to DNA material
Birth Defects, Cancer, Chemical Sensitivities, Premature aging
Slide37Phase I - Bottlenecks
Foreign chemicals are metabolized into alcohols that must be metabolized into an aldehyde, then converted into uric acid and then excreted.
This process relies heavily on enzymes, one of which is alcohol dehydrogenase. Requires Zinc, Molybdenum and Iron
Result -Chloral Hydrate-“Mickey Finn”
Slide38Phase II - Bottlenecks
Low levels of GSH.
Requires Vitamin B-3 or NiacinSulfur Deficiency These aminos have sulfhydryl groups
Glutathione PeroxidaseRequires SeleniumGlutathione ReductaseRequires Riboflavin (severe loss of riboflavin can occur from the use of oral contraceptives)
Slide39Phase I Overload
If the alcohol and aldehyde paths slow down, the body may shift chemistry to metabolites called epoxides.
Epoxides are highly unstable and highly reactive capable of making changes that may potentially lead to cancer.Frequent epoxidation increases cancer risk.
Slide40Epoxidation
Chemicals can be contributing factors to cancer if the body is not able to efficiently detoxify and clear them away.
Difficult to actually blame any particular substance conclusively, due to multiple detox pathways and inefficient metabolic processes.
Slide41Causes of Epoxidation
Nutritional Deficiencies
Impairment of enzymatic functionHeavy MetalsDamage to DNA
Damage to cellular communication systemLoss of regulatory functions within detoxification systems.
Slide42Epoxidation
“Orphan” chemicals raise havoc with cells.
Damage to cellular tissues occurs.Partially metabolized chemicals travel throughout the body, causing problems until they can be conjugated or metabolized through enzymatic action.Once leaked into the cell, they attach to structures like mitochondria and ER, further reducing energy production and detoxification efforts.
Slide43Detox Pathways
Epoxidation
Xenobiotic
ConjugateBile, Bowel
Alcohol
Allergies
Cancer
Urine
Uric Acid
Aldehyde
Chloral Hydrate
Phase I
Phase II
Slide44Minerals and Vitamins
Epoxidation
Xenobiotic
SulphurMagnesiumSeleniumNiacin
Riboflavin
AAs
Vitamins
Fatty Acids
Bile, BowelAlcohol
Allergies
Cancer
Urine
Molybdenum
Zinc
Chloral Hydrate
Phase I
Phase II
Slide45How the sick get sicker
Chemicals back up into the blood stream.
Chemicals get stored in the fat and brain.Chemicals recycle in the overloaded detox paths.Formulation of metabolites worse than the original compound, creating free radicals.
Chemicals get bounced around creating problems.Chemicals poison the energy and detox systems.Backlogged chemicals damage the endocrine, nervous and immune systems.
Slide46Processed Foods
Devitalized
Prolonged exposure to chemicalsDiets high in chemicalsDiets affected by hormones, antibiotics
Concentrated processed foods
Slide47Mineral Depletion From Sugar
Sugar depletes chromium.
Causes excessive loss of minerals.Increases demand for acid buffers.Oxygen scavenger.
Slide48Magnesium
Required in over 300 enzymatic functions.
Possibly the link between sudden death in athletes. High amounts are lost in sweat.Experts believe that over 80% of the population is magnesium deficient.Chronic back and neck pain, muscle spasm, panic attacks, Raynaud’s disease, fatigue, arrhythmia.
Slide49Manganese
Required in Super Oxide Dismutase
Required to make precursor to GlutathioneRequired in Glutamine - Brain functionRequired for Adrenal and Nerve function
Deficiency related to senility and memory
Slide50Copper
Oxidase Enzymes -- Chemical detox
Monoamine Enzymes -- NeurotransmittersTyrosinase, CeruloplasminSOD - Free radicals
Dopa Oxidase -- NeurotransmittersCytochrome C -- Energy
Slide51Iron
Needs - Magnesium, Nickel, Copper, Zinc and Manganese.
Necessary for hemoglobin and myoglobin oxygen transport and storage.Aldehyde oxidase, OxidoreductasesRequired for Cytochrome P-450 Phase I
Slide52Iodine
Thyroxine (T-3, T-4)
Known as the metabolizer.Stored in thyroid and ovaries.Low iodine levels swell thyroid glands.
Low iodine related to fibrocystic breasts and soreness of the breasts.
Slide53Zinc
Pivotal in Phase I detoxification in the liver
Required in over 90 enzymesStudies show that 13% of patients tested had adequate levels of zinc.Aids in gene repair
Carbonic Anhydrase-Keeps “Mickey Finn” away!
Slide54Molybdenum
Essential in four enzymes including aldehyde oxidase and xanthine oxidase, which is a pre-cursor to the sulfo transferases.
Aids in metabolism of sulfur-containing amino acids.Aids in metabolism of some steroids and hormones.
Aids in sulphur-oxidation. Coal plants, sulfites in foods such as beer, french fries and shrimp.
Slide55Selenium
Antioxidant
Glutathione peroxidase and is used in the recycling of Glutathione (GSH). Oxidoreductases, tocopherol, sulphur amino acid metabolismEssential in maintaining the GSH cycle.
Slide56Sulfur
Used in Phase II conjugation processes.
Required for 3’Phosphoadenosine, and 5’Phosphoadenosene -- PAPS
Slide57Eat Right!
Eliminate processed foods
Eliminate sugar from the dietDrink spring waterAdd vegetables to diet
Increase lentils, chickpeas, beans, etc.Vary diet daily-- eat a wide variety of healthy foods.Go organic!
Slide58Test for minerals that balance
Oligo minerals are bioavailable and ready for assimilation. Singles or in combination.
Geophasics uses combination mineral theory- to support specific areas in need. Oligo minerals support the Krebs cycle.
Supplements come in various forms-- check for which provides the best balance.
Slide59Testing for balance
Select the mineral to be tested.
Test on LI-CMP at a 1V dilution; if the point balances, encourage consumption of foods that have that mineral.If the point doesn’t balance, add products to testing tray until the point balances.
You may have to use combinations.
Slide60Testing Minerals and Vitamins
Should be an integral part of working the balances that you do.
Aids the client in doing what balances the best using a biochemical individuality test.Imprint minerals only if you know that there is an adequate diet, or if balancing signals are over 200X.
Slide61Homeopathic Remedies
Opsin I and Opsin II
Lieno -- Cleans the blood, supports spleenHepato -- Drains liver, aids in cleansingOligo Minerals -- Provide key functions
Phoenix Liquitrophic -- Acetyl aldehydePhoenix II – Endoplasmic reticulum, cellsAmino Liquitrophic -- cellular resourceGeophazx according to Homotoxic Phase
Slide62Xenobiotic Homeopathics
Environmental Pollutants
Industrial PollutantsChlorexRadiation
Heavy MetalsDental MaterialsAsbestox
Slide63Supplements
Acidophilus
Bovine ColostrumLiquid MineralsLiquid Vitamins
Slide64Bovine Colostrum
High in proteins -- Low in fat
High in immunogobulins to build antibodiesIgG Mother’s milk 2% IgG Bovine 86% Proteins include hormones, enzymes, complex glyconutrionals, and growth factor that speeds up healing.
The greatest area of immunity strengthening is in the lungs and large intestine.
Slide65Organs to Support
KidneysSpleen
Liver
Slide66Resources
Is This My Child’s World?Dr. Doris J. Rapp, MDTired Or Toxic?
Dr. Sherry Rogers, MD
Slide67I A B P
IABP, Inc. All Rights Reserved Copyright 2000
International Academy of Bionetic Practitioners, Inc.
2160 W. Drake Rd Unit A-1Fort Collins, CO 805261-970-224-2850