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I A B P Copyright 2000 IABP, Inc. I A B P Copyright 2000 IABP, Inc.

I A B P Copyright 2000 IABP, Inc. - PowerPoint Presentation

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I A B P Copyright 2000 IABP, Inc. - PPT Presentation

Body Systems Skeletal Muscular Digestive Circulation Nervous Respiratory Dermal Reproduction Lymphatic Detoxification Immune Regulatory The Detoxification System The process of metabolizing ID: 779369

chemicals phase detoxification body phase chemicals body detoxification minerals detox gsh common foods enzymes acid damage process glutathione zinc

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Slide1

I A B P

Copyright 2000 IABP, Inc.

Slide2

Body Systems

Skeletal Muscular

Digestive CirculationNervous RespiratoryDermal Reproduction

Lymphatic DetoxificationImmune Regulatory

Slide3

The Detoxification System

The process of metabolizing

Hydrocarbons and

Mycotoxins within the body.

Slide4

Hydrocarbons can be synthesized from coal and petroleum.

They are known as:

Petrochemicals or foreign chemicalsVolatile Organic Hydrocarbons – VOCsAliphatic Hydrocarbons

Aromatic HydrocarbonsFormaldehyde, Aldehydes, CyanidesReferred to as “Xenobiotics”.

Slide5

Mycotoxins

Natural poisons from molds and fungus on foods and in the air.

Involved in decomposition processes.Metabolized byproducts from within the body.

Slide6

There are currently no universally accepted tests available to determine xenobiotic toxicity.

Patient Indicators:

Allergic Responses – Asthma, Histamine ReleaseFatigue – Exhaustion, Tired upon rising

Memory – Lapses, short-term and long-termSleepy – Tired in afternoon or after sleepingSkin Reactions – Rashes, Eczema, HivesAutoimmune – Hyper-Responsive

Nerves – Disorders, depression, impaired motor function

Brain – Cognition, attention span, speech center, emotions

Physiology – Agitation, anxiety, menses, cravings, addictions

Slide7

Situation

A person visits the doctor complaining of various symptoms. The doctor often has limited means for understanding exactly what the cause is.The person is desperate to find someone who knows how to solve the problem(s).

Slide8

Common Names

Multiple Chemical Sensitivity – MCS

Allergic ReactionUniversal ReactorEnvironmental Illness

Slide9

Clinical Ecology-Accepted Test

Provocative Neutralization developed by Dr. Theron Randolph.

Proven theory based on homeopathic principles and research by Dr. Jaques Benveniste.

Slide10

Common Therapy

:

Cortisone Antihistamines Antidepressants

Steroids

Slide11

Xenobiotics are introduced through:

Skin Breathing Ingestion

Metabolic byproducts

Slide12

If you can smell it, it has already entered the bloodstream!

Dopey

DizzySpaceyUnable to concentrate

Slide13

Common Chemical Exposures

Trichloroethylene -- TCE

BenzeneToluene Phenol

XyleneStyrene

Slide14

Benzene-Toluene-Phenol-Xlyene

Known causes of leukemia

Lipid-soluble chemicalsEasily pass into lipid cell membranesEasily pass into blood stream after inhaling

Special affinity for the brain, a lipid rich organ.

Slide15

Common Symptoms

Depression

ExhaustionDizzinessHeadache

Inability to think clearly

Slide16

Analysis of air over vinyl floor

Toluene Benzyl Chloride

Phenol Benzol ChlorideTrichloroethane Benzyl Butyl EtherBenzaldehyde Decanol

Butanol 1-(2-butoxy ethoxy)Hexanol 2-butanone - ethanolCyclohexanone

Slide17

Common Chemicals in Carpet

FormaldehydeTolueneXylene

BenzeneMethacrylateTetrachloroethyleneMethyl Naphthalene

Slide18

Common Symptoms of Trichloroethylene Exposure

Poor Concentration Confusion

Poor Coordination HeadacheUndue Fatigue DizzinessDrowsiness Muscle Cramps

Slowed Responses Slowed DecisionsNumbness, Tingling

Slide19

Common products containing

Trichloroethylene

Solvents in machines and oilsDry cleaning fluid on clothesCarpet shampoo

Floor polishCopy Machines -- outgasGluesCorrection fluid

Slide20

Hospital Air Analysis

Acetone Acrolein AmmoniaBenzene Carbon Dioxide ChlorineMercury Ethylene Oxide Methane

Phenols Formaldehyde NitrogenOzone Phosphates HydroxidesStyrene Sulphur Compounds TolueneXylene Nitrous Oxides

Slide21

Exhaled Breath Analysis

355 New Jersey Urban Residents -1984

Chloroform TrichloroethaneBenzene StyreneO-xylene Xylene

Dichlorobenzene TrichloroethyleneTetrachloroethylene Carbon Tetrachloride

Slide22

Yeast and Fungus

Body creates antibodies against the yeast and molds in the gut.

Byproducts create mycological toxinsAntibodies stimulate histamine release. Responses in body are allergic in nature.Candida Albicans create acetaldehyde.

Puts pressure on the detoxification paths.

Slide23

Candida Albicans

Over 500 known symptoms

Adds to allergic burden and toxic loadCreates mycological toxinsCauses sugar cravings

Can live in acid terrain, caused by amalgams and pesticides.

Slide24

Healthy Gut Flora

Reduces aldehydes, ketones, alcoholsHydrolysis of glucuronides, sulfates, oxides and esters.Dehydroxylation of C- and N-Hydroxy compounds

DecarboxylationDehalogenation

Slide25

The Detoxification System

Housed in every cell of the body.

Used as a defense system for poisons.Understanding this system holds the key to clearing previously impossible to address conditions.

Slide26

Metabolized Process

Functional process has limits based on resources.

May biotransform into other toxins that are worse.Detoxification process to adapt to the toxin.

Slide27

Once in the the blood stream

The body then has two goals for chemical poisons:

Make the chemicals less poisonous.

Excrete them as quickly as possible.

Slide28

Phase - I Detoxification

Liver Function

Endoplasmic Reticulum -- Cytochrome P-450 Oxidation

Reduction Hydrolysis

Slide29

Phase I (E R) - Responses

Oxidation / Reduction / Hydrolysis

Burning off an electron, adding an electron, or removing hydrogen from the original compound. If this is successful, excretion by the kidneys can occur.

Slide30

Phase II - Conjugation

Cytoplasm of the cell -- Cytosol

Polarization of the chemical by adding amino acid or protein, which changes the charge and increases the odds of excretion through the bowel.

Slide31

Conjugation with

Glutathione (GSH)

Predominant process using glutathione, which is comprised of:Glutamic AcidCysteine

Glycene

Slide32

GSH - Glutathione

If there is insufficient GSH available due to Phase II detoxification, then other systems that need GSH are weakened.

Slide33

Phase II Detoxification Cont.:

Glycene and Cysteine Conjugation

Requires SulphurGlucuronic Acid ConjugationRequires Zinc

PAPS - Conjugation3’Phosphoadenosine, 5’PhosphoadenoseneRequires Cysteine

Slide34

Biotransformaton or Detox?

Enzymes-- specialized proteins Reaction specific-may or may not aid in detoxification or biotransformation: - If the enzyme has the key to the problem, it will.

- On the other hand, if the enzyme can’t be activated due to vitamin or mineral deficiency, it won’t.

Slide35

Phase - II Detoxificaton

Comprised of Twelve Pathways

Genetics -- What enzymes are available?Nutrient Levels -- Vitamins, Minerals, Amino Acids, Essential Fatty Acids.Total “Load” -- How many chemicals are already in the body? Subsequent exposures?

Detox Damage -- Which pathways cannot be used due to previous damage?

Slide36

Problems associated with impaired detox pathways:

Toxins attach to the liver and kidneys.

Toxins attach to GSH.Irreparable damage to a detox pathwayToxins attach to DNA material

Birth Defects, Cancer, Chemical Sensitivities, Premature aging

Slide37

Phase I - Bottlenecks

Foreign chemicals are metabolized into alcohols that must be metabolized into an aldehyde, then converted into uric acid and then excreted.

This process relies heavily on enzymes, one of which is alcohol dehydrogenase. Requires Zinc, Molybdenum and Iron

Result -Chloral Hydrate-“Mickey Finn”

Slide38

Phase II - Bottlenecks

Low levels of GSH.

Requires Vitamin B-3 or NiacinSulfur Deficiency These aminos have sulfhydryl groups

Glutathione PeroxidaseRequires SeleniumGlutathione ReductaseRequires Riboflavin (severe loss of riboflavin can occur from the use of oral contraceptives)

Slide39

Phase I Overload

If the alcohol and aldehyde paths slow down, the body may shift chemistry to metabolites called epoxides.

Epoxides are highly unstable and highly reactive capable of making changes that may potentially lead to cancer.Frequent epoxidation increases cancer risk.

Slide40

Epoxidation

Chemicals can be contributing factors to cancer if the body is not able to efficiently detoxify and clear them away.

Difficult to actually blame any particular substance conclusively, due to multiple detox pathways and inefficient metabolic processes.

Slide41

Causes of Epoxidation

Nutritional Deficiencies

Impairment of enzymatic functionHeavy MetalsDamage to DNA

Damage to cellular communication systemLoss of regulatory functions within detoxification systems.

Slide42

Epoxidation

“Orphan” chemicals raise havoc with cells.

Damage to cellular tissues occurs.Partially metabolized chemicals travel throughout the body, causing problems until they can be conjugated or metabolized through enzymatic action.Once leaked into the cell, they attach to structures like mitochondria and ER, further reducing energy production and detoxification efforts.

Slide43

Detox Pathways

Epoxidation

Xenobiotic

ConjugateBile, Bowel

Alcohol

Allergies

Cancer

Urine

Uric Acid

Aldehyde

Chloral Hydrate

Phase I

Phase II

Slide44

Minerals and Vitamins

Epoxidation

Xenobiotic

SulphurMagnesiumSeleniumNiacin

Riboflavin

AAs

Vitamins

Fatty Acids

Bile, BowelAlcohol

Allergies

Cancer

Urine

Molybdenum

Zinc

Chloral Hydrate

Phase I

Phase II

Slide45

How the sick get sicker

Chemicals back up into the blood stream.

Chemicals get stored in the fat and brain.Chemicals recycle in the overloaded detox paths.Formulation of metabolites worse than the original compound, creating free radicals.

Chemicals get bounced around creating problems.Chemicals poison the energy and detox systems.Backlogged chemicals damage the endocrine, nervous and immune systems.

Slide46

Processed Foods

Devitalized

Prolonged exposure to chemicalsDiets high in chemicalsDiets affected by hormones, antibiotics

Concentrated processed foods

Slide47

Mineral Depletion From Sugar

Sugar depletes chromium.

Causes excessive loss of minerals.Increases demand for acid buffers.Oxygen scavenger.

Slide48

Magnesium

Required in over 300 enzymatic functions.

Possibly the link between sudden death in athletes. High amounts are lost in sweat.Experts believe that over 80% of the population is magnesium deficient.Chronic back and neck pain, muscle spasm, panic attacks, Raynaud’s disease, fatigue, arrhythmia.

Slide49

Manganese

Required in Super Oxide Dismutase

Required to make precursor to GlutathioneRequired in Glutamine - Brain functionRequired for Adrenal and Nerve function

Deficiency related to senility and memory

Slide50

Copper

Oxidase Enzymes -- Chemical detox

Monoamine Enzymes -- NeurotransmittersTyrosinase, CeruloplasminSOD - Free radicals

Dopa Oxidase -- NeurotransmittersCytochrome C -- Energy

Slide51

Iron

Needs - Magnesium, Nickel, Copper, Zinc and Manganese.

Necessary for hemoglobin and myoglobin oxygen transport and storage.Aldehyde oxidase, OxidoreductasesRequired for Cytochrome P-450 Phase I

Slide52

Iodine

Thyroxine (T-3, T-4)

Known as the metabolizer.Stored in thyroid and ovaries.Low iodine levels swell thyroid glands.

Low iodine related to fibrocystic breasts and soreness of the breasts.

Slide53

Zinc

Pivotal in Phase I detoxification in the liver

Required in over 90 enzymesStudies show that 13% of patients tested had adequate levels of zinc.Aids in gene repair

Carbonic Anhydrase-Keeps “Mickey Finn” away!

Slide54

Molybdenum

Essential in four enzymes including aldehyde oxidase and xanthine oxidase, which is a pre-cursor to the sulfo transferases.

Aids in metabolism of sulfur-containing amino acids.Aids in metabolism of some steroids and hormones.

Aids in sulphur-oxidation. Coal plants, sulfites in foods such as beer, french fries and shrimp.

Slide55

Selenium

Antioxidant

Glutathione peroxidase and is used in the recycling of Glutathione (GSH). Oxidoreductases, tocopherol, sulphur amino acid metabolismEssential in maintaining the GSH cycle.

Slide56

Sulfur

Used in Phase II conjugation processes.

Required for 3’Phosphoadenosine, and 5’Phosphoadenosene -- PAPS

Slide57

Eat Right!

Eliminate processed foods

Eliminate sugar from the dietDrink spring waterAdd vegetables to diet

Increase lentils, chickpeas, beans, etc.Vary diet daily-- eat a wide variety of healthy foods.Go organic!

Slide58

Test for minerals that balance

Oligo minerals are bioavailable and ready for assimilation. Singles or in combination.

Geophasics uses combination mineral theory- to support specific areas in need. Oligo minerals support the Krebs cycle.

Supplements come in various forms-- check for which provides the best balance.

Slide59

Testing for balance

Select the mineral to be tested.

Test on LI-CMP at a 1V dilution; if the point balances, encourage consumption of foods that have that mineral.If the point doesn’t balance, add products to testing tray until the point balances.

You may have to use combinations.

Slide60

Testing Minerals and Vitamins

Should be an integral part of working the balances that you do.

Aids the client in doing what balances the best using a biochemical individuality test.Imprint minerals only if you know that there is an adequate diet, or if balancing signals are over 200X.

Slide61

Homeopathic Remedies

Opsin I and Opsin II

Lieno -- Cleans the blood, supports spleenHepato -- Drains liver, aids in cleansingOligo Minerals -- Provide key functions

Phoenix Liquitrophic -- Acetyl aldehydePhoenix II – Endoplasmic reticulum, cellsAmino Liquitrophic -- cellular resourceGeophazx according to Homotoxic Phase

Slide62

Xenobiotic Homeopathics

Environmental Pollutants

Industrial PollutantsChlorexRadiation

Heavy MetalsDental MaterialsAsbestox

Slide63

Supplements

Acidophilus

Bovine ColostrumLiquid MineralsLiquid Vitamins

Slide64

Bovine Colostrum

High in proteins -- Low in fat

High in immunogobulins to build antibodiesIgG Mother’s milk 2% IgG Bovine 86% Proteins include hormones, enzymes, complex glyconutrionals, and growth factor that speeds up healing.

The greatest area of immunity strengthening is in the lungs and large intestine.

Slide65

Organs to Support

KidneysSpleen

Liver

Slide66

Resources

Is This My Child’s World?Dr. Doris J. Rapp, MDTired Or Toxic?

Dr. Sherry Rogers, MD

Slide67

I A B P

IABP, Inc. All Rights Reserved Copyright 2000

International Academy of Bionetic Practitioners, Inc.

2160 W. Drake Rd Unit A-1Fort Collins, CO 805261-970-224-2850