PPT-Protein therapeutics

Soma Mukherjee SMUChemistry 5 th April2011 Introduction Protein amp important structural features for therapeutics Development Classification Examples of Protein as targeted delivery device. Staining total protein before specific protein de tection techniques provides an assessment of protein transfer efficiency and makes it possible to detect contaminating proteins in the sample and to compare the sample with molecular weight standards This is accomplished by an extraordinarily thin microporous PTFE balloon which controllably engages the vessel wall to occlude blood flow dur ing infusion By limiting flow during infusion drug concentration to the targeted loca tion can increase upw TFIIF. TFIIA. RNA Pol II. TFIID. TFIIB. core promoter. exon 1. Cactus. Dorsal. Dorsal. Tube. Pella. Pella. Tube. Spatzle. Toll. So. Eya. Su(H. ). CtBP. Gro. Delta. Kuz. Detecting Protein-Protein Interactions. Jr. Discovery of Cyclic AMP. Ferid. . Murad. Nitric Oxide Signaling. Alfred G. Gilman. G-protein Signal Transduction. Heritage of the CWRU Department of Pharmacology. Nobel Prize. Kris Palczewski, Chairman of Pharmacology. Interactions. June 6, 2017. Why PPI?. Protein-protein interactions determine outcome of most cellular processes. Proteins which are close homologues often interact in the same way. Protein-protein interactions place evolutionary constraints on protein sequence and structural divergence. Contains . carbon, hydrogen. , oxygen, and nitrogen. Remember carbohydrates and lipids contain carbon, hydrogen, and oxygen – SO protein adds . nitrogen. Some proteins also contain sulfur, iron. , copper, phosphorus, or . John B. Buse, MD, PhD. Verne S. . Caviness. Distinguished Professor. Chief, Division of Endocrinology. Director, NC Translational and Clinical Sciences Institute. Executive Associate Dean, Clinical Research. A nutrient found in all living things. It contains nitrogen and is responsible for the formation, maintenance, and repair of the body’s tissues/ It can also be used for energy. CHNO. Amino acids . 4. calories per gram. . The main function of protein is to . build and repair body tissues. .. If carbohydrates and fat are not available, your body will use protein. Is this a good thing? . You must eat protein . 2020Corporate PresentationMarch 2021Certaininformationsetforthinthispresentationcontainsforward-lookinginformationincludingfutureorientedfinancialinformationandfinancialoutlookunderapplicablesecuritie 2020Corporate PresentationMarch 2021Certaininformationsetforthinthispresentationcontainsforward-lookinginformationincludingfutureorientedfinancialinformationandfinancialoutlookunderapplicablesecuritie National Healthcare Safety Network NHSN LTCF COVID19 Module TrainingDate June 2021Presenter Molly Stillions RN MSNNurse Infection Preventionist Division of Healthcare Quality Promotion Centers for Dis Mukherjee. SMU,Chemistry. 5. th. April’2011. Introduction : Protein & important structural features for therapeutics.. Development. Classification. Examples of Protein as targeted delivery device. This has proved to be a very challenging problem. It has aptly been described as the second half of the genetic code, and as the three-dimensional code, as opposed to the one-dimensional code involved in nucleotide/amino acid sequence. .