PPT-Using Exons to Define

Isoforms in PRO Timothy Danford Novartis Institutes for Biomedical Research PRO AlzForum Kickoff Meeting Oct 4 2011 Genes vs Proteins Gene Transcript Exon Locus Allele Variant SNP. A. . ZMYM6. -variant missing Exon 2. C. . ZMYM6. -variant missing Exon 4. B. . ZMYM6. -variant missing Exon 5. D. . ZMYM6. -variant missing Exons 4 & 5. Exon 6. Exon 3. Exon 6. Exon 4. Exon 5. Exon 3. DNA .  RNA  Protein. 2 Major Steps. Transcription. – DNA is transcribed (copied!) into single stranded mRNA . (DNA code transcribed into RNA code). Translation. – mRNA is translated into protein (amino acids). Maximum Likelihood (ML) Model. Introduction. . Alternative Splicing. Simulation Setup: . human genome data (UCSC hg18) . UCSC database - 66, 803 . isoforms. 19, 372 genes, Single error-free reads: 60M of length 100bp. Caciula. Department of Computer Science. Georgia State. University. Joint work with . Serghei. . Mangul. (GSU) . Ion . Mandoiu. (UCONN) . Alex . Zelikovsky. (GSU). RNA-. Seq. based discovery and reconstruction of . By: Nick . Belsanti. and Kevin . Kukla. Translation. The DNA of a cell makes mRNA which travels to the ribosome where it reads the sequence of the ribosome and then produces the protein by making amino acids that combine. . Breakthrough in genome editing.. The most important scientific result . of the year 2015.. “Science“,18 December 2015. I will report first about. Duchenne muscular dystrophy,. because there were serious problems . Read Binning. Student: Gabriel Ilie. Major advisor: Ion Măndoiu. Associate Advisor: Sanguthevar Rajasekaran. Associate Advisor: Yufeng Wu. University of Connecticut. November 2013. indictment (noun) – accusation; complaint. drily (adverb) – matter-of-factly; without emotion. exasperated (adjective) – irritated; annoyed. oppression (noun) – feeling of being greatly troubled or harshly treated. Q. What are the four strands of globalisation with an example?. A. Social – . international immigration. Political – . t. he growth of trade blocs. Cultural – . the dominance of western culture. What do the following words mean?. frail. suede. presentable. mistrust. barren. I can define new words. .. frail:. delicate; weak and fragile. Sentence:. He looked as if he was fourteen or fifteen, . Jim . Sattler. About the Speaker. Over 20 years of pharmaceutical industry experience. Lecturer in SAS System Programming at University of California, Berkeley.. Dynamic Programming II Gene Prediction: Similarity-Based Approaches The idea of similarity-based approach to gene prediction Exon Chaining Problem Spliced Alignment Problem Gene Prediction Computational problem of predicting the locations of genes in a genome given only the genomic DNA sequence (gene is broken into pieces called as exons that are separated by junk NDA/introns). BMI/CS 776 . www.biostat.wisc.edu/bmi776/. Spring . 2018. Anthony Gitter. gitter@biostat.wisc.edu. These slides, excluding third-party material, are licensed under . CC BY-NC 4.0. by Mark Craven, Colin Dewey, and Anthony Gitter. Muniath’s. Notes. RDA 2. 12. th. March 2020. 1. 2. Lectures to be covered. Labour. Child Growth and Development. Adolescence and Puberty. Ageing. 3. 1. Labour- Learning Objectives. Term delivery: define 'term' delivery and recognise birth as the final phase of pregnancy.