B C Lacune Perivascular spaces Microbleeds Acute infarct A DWI FLAIR T1 S WI T2 S WI DWI Oct 20 19 May 20 20 June 2020 Sept 20 20 March 2019 October 2020 Fig 2 ID: 1048382
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1. Fig 1White matter hyperintensitiesBC Lacune Perivascular spacesMicrobleedsAcute infarctADWIFLAIRT1SWIT2SWIDWIOct 2019May 2020June 2020Sept 2020March 2019October 2020
2. Fig 2LR00.10.20.30.40.5CVR [%/mmHg]CVR Delay [s]05040302010PSvPT2BACVR mag [%/mmHg]FLAIRCVR Delay [s]
3. Fig 3A. CSF pulsation at the foramen magnum over one cardiac cycle Basal Ganglia PVS scoreCSF stroke volumeBasal Ganglia PVS scoreB. Intracranial vascular and CSF pulsation varies with perivascular space visibilitySagittal sinus PI******Sagittal sinus PI
4. Fig 4
5. EC dysfunctionWM changeHypertensionIntravascular stasesArteriolosclerosisMicrobleedsCerebral infarcts3 5 8 12 18 24 >30 weeks of ageOPCsOligo-dendrocytesFig 5Early life risk factors:Cognitive ability, education, socioeconomic statusgeneticsMid life risk factorshypertensiondiabetessmokingexercisemany yet unknown