PPT-  Precision Medicine For Aggressive Lymphoma

PMAL Consortium and Associated Trials 2016 CONFIDENTIAL The new name for Leukaemia amp Lymphoma Research Tackling Diffuse Large Bcell Lymphoma 2 Clinical Problem Standard of care RCHOP results in cure rates around 75. From Promise to Practice. PRECISION ONCOLOGY IS THE FUTURE OF CANCER CARE.. Tumor genome data informs cancer treatment and clinical pathways, resulting in better health outcomes.. New cancer therapies target the molecular pathways that lead to tumor genesis and progression.. Apostolia M. Tsimberidou, . MD, PhD. Professor . Investigational Cancer Therapeutics. Incorporation of Levels of Evidence into Variant Reporting/Clinical Practice. Implementation of CAP, AMP, ASCO recommendations. Monday, November 14, 2016. Session Objectives. Understand . Precision Medicine and why a diverse cohort is crucial for success. Describe the nuanced issues in Precision Medicine and genetic research as applied to Native populations. 1. 2015 Precision Medicine Initiative: . Two Components: Cancer & National Cohort. “. An emerging approach for disease prevention and treatment that takes into account people’s individual variations in genes, environment, and lifestyle”. Jeremy Warner . MD, MS. Assistant Professor of Medicine and Biomedical . Informatics. Vanderbilt University. June 26, 2017. Three questions every cancer patient asks. Who’s like me?. How long have I got?. Robert A. Somer, MD. Head, Medical Oncology and Hematology. Director, Office of Clinical Research. MD Anderson Cancer Center- Cooper. What is Cancer?. Official Definition: A malignant proliferation of cells that is a result of a . Program Goals. DLBCL Subtypes . 2008 WHO Classification. Other DLBCL Variants. Dissecting DLBCL into Molecularly and Clinically Distinct Subgroups by Gene Expression Profiling. Outcomes Based on DLBCL Subtype Using Gene Expression Profiling. Introduction. How Has Precision Medicine Changed the Treatment Landscape in Oncology?. Selection of Biomarkers in Drug Development. Methods to Identify Driver Mutations. Which Method Should Be Used?. with Double-Hit Genetics by . Chromothripsis. Identified on Chromosomal Microarray. EAHP16-LYWS-281. Charles . Van . Slambrouck. . MD, Kai . Lee Yap PhD. , Sandeep . Gurbuxani. MBBS PhD, . Joo. Song MD, . July 201 MaeÕr ddogfen yma hefyd ar gael yn Gymraeg. This document is also available in Welsh. #$%&'!#%()$*+,-./!01232! 1 Genomics for Precision Medicine Strategy Executive Summary New genetic and g Overview Case 3 • 59 year old man with lymphadenopathy in the neck, supraclavicular area, inguinal area . He states that he has had LN for at least 18 months and they have waxed and waned . Karen L. Edwards, . PhD. Professor, Dept. of Epidemiology. School of Medicine. University of . California, Irvine. Irvine, CA. Outline. Two National Initiatives . Precision Medicine Initiative . Cancer . Biochemistry. qxsang@chem.fsu.edu. Biochemical, Molecular, and Pathological Mechanisms of Cancer, Stroke, Obesity, and Stem Cell Differentiation, and Cancer Biomarker and Drug Discovery for Precision . Owen Tan. 1. , Deborah Schofield. 1. , Rupendra Shrestha. 1. 1. GenIMPACT: Centre for Economic Impacts of Genomic Medicine, Macquarie Business School, Macquarie University, Australia.. Presenting at: .