embryo interaction Nava Deke l Israe l Approximately half of all human embryo implantations result in failed pregnancy a ttributed in many cases to poor uterine receptivity We as well as ID: 521258
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Implantation: the immune system partakes in the maternal - embryo interaction Nava Deke l , Israe l Approximately half of all human embryo implantations result in failed pregnancy , a ttributed , in many cases , to poor uterine receptivity. We, as well as others, have demonstrated that endometrial biopsies performed either during the spontaneous, preceding cycle, or during the IVF cycle itself, significantly improve the rate of implantation, clinical pregnancies and live births. These observations suggest that mechanical injury of the endometrium may enhance uterine receptivity by provoking the immune system to generate an inflammatory reaction. In this presentation I will discuss the hypothesis that the injury - de rived inflammation in the biopsy - treated uterus recruits immune cells that, in turn, enhance the endometrial expression of essential molecules , which facilitat e the interaction between the embryo and the uterine epithelium.